دورية أكاديمية
أعرض في EDS

How to hit the allergy target: A critical appraisal of intralymphatic immunotherapy with practical recommendations on ultrasound-guided injections.

التفاصيل البيبلوغرافية
العنوان: How to hit the allergy target: A critical appraisal of intralymphatic immunotherapy with practical recommendations on ultrasound-guided injections.
المؤلفون: Flory S; Department of Dermatology, University of Zurich, Zurich, Switzerland., Hviid-Vyff B; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Šošić L; Department of Dermatology, University of Zurich, Zurich, Switzerland., Schmid JM; Department of Respiratory Diseases and Allergy, Aarhus University, Aarhus, Denmark., Ahlbeck L; Allergy Center, University Hospital Linköping, Linköping, Sweden., Widmer ECJ; Department of Dermatology, University of Zurich, Zurich, Switzerland., Lang CCV; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland., Ikenberg K; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Kündig TM; Department of Dermatology, University of Zurich, Zurich, Switzerland.; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland., Hoffmann HJ; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Johansen P; Department of Dermatology, University of Zurich, Zurich, Switzerland.; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
المصدر: Allergy [Allergy] 2024 Aug; Vol. 79 (8), pp. 2222-2234. Date of Electronic Publication: 2024 May 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 7804028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1398-9995 (Electronic) Linking ISSN: 01054538 NLM ISO Abbreviation: Allergy Subsets: MEDLINE
أسماء مطبوعة: Publication: Copenhagen : Wiley-Blackwell
Original Publication: Copenhagen, Munksgaard.
مواضيع طبية MeSH: Desensitization, Immunologic*/methods , Hypersensitivity*/therapy, Humans ; Female ; Male ; Adult ; Injections, Intralymphatic ; Middle Aged ; Young Adult ; Allergens/administration & dosage ; Allergens/immunology ; Retrospective Studies ; Lymph Nodes/immunology ; Lymph Nodes/diagnostic imaging ; Ultrasonography, Interventional/methods
مستخلص: Background: Intralymphatic immunotherapy (ILIT) represents a promising novel approach treating allergic diseases. However, no standardized procedures or recommendations have been established or reported, despite the recognized fact that treatment efficacy relies on the ability to inject the allergen intranodally.
Objective: We aim to provide a critical appraisal of ILIT as a method of allergen immunotherapy and to deliver practical recommendations for accurate ILIT.
Methods: One hundred and seventy-three ILIT injections were performed in 28 (47%) women and 32 (53%) men with median age of 29 years (21-59). The injections were ultrasound-guided and recorded for retrospective analysis with respect to injection location, needle visibility, medication release, and patient characteristics.
Results: The results show that the correct positioning of the needle within the lymph node (LN) was most critical. If the whole length of the needle bevel was not inserted into the LN, substance backflush into the interstitium was observed. Selecting a more superficial LN and inserting the needle at a smaller angle towards the LN significantly improved needle visibility in the ultrasound. Longitudinal results showed that continuous practice significantly correlated with improved needle visibility and more accurate ILIT injections.
Conclusion: Based on our results and practical experience, we propose several recommendations for LN selection and the correct handling of ultrasound probe and needle. We are confident that ILIT standardization and training will be important as to meet the goals of good safety and efficacy of ILIT.
(© 2024 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: Universität Zürich; Innovationsfonden
فهرسة مساهمة: Keywords: allergen immunotherapy; allergy; intralymphatic immunotherapy; ultrasound
المشرفين على المادة: 0 (Allergens)
تواريخ الأحداث: Date Created: 20240507 Date Completed: 20240731 Latest Revision: 20240731
رمز التحديث: 20240731
DOI: 10.1111/all.16138
PMID: 38712754
قاعدة البيانات: MEDLINE
الوصف
تدمد:1398-9995
DOI:10.1111/all.16138