دورية أكاديمية
Biomarkers of gastrointestinal nematodes in beef cattle raised in a tropical area.
| العنوان: | Biomarkers of gastrointestinal nematodes in beef cattle raised in a tropical area. |
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| المؤلفون: | Rodrigues VD; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., Borges DGL; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., Conde MH; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., de Freitas MG; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., do Nascimento Ramos CA; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., de Souza AI; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., Reckziegel GH; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil., de Castro Rodrigues D; MSD Saúde Animal, São Paulo, Brazil., Borges FA; Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil. fernando.borges@ufms.br.; Laboratório de Doenças Parasitárias, Faculdade de Medicina Veterinária E Zootecnia, Universidade Federal de Mato Grosso Do Sul, Avenida Senador Filinto Müller, Campo Grande, MS, 2443, Brazil. fernando.borges@ufms.br. |
| المصدر: | Parasitology research [Parasitol Res] 2024 May 07; Vol. 123 (5), pp. 207. Date of Electronic Publication: 2024 May 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1955 (Electronic) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer International, c1987- |
| مواضيع طبية MeSH: | Cattle Diseases*/parasitology , Cattle Diseases*/drug therapy , Biomarkers*/blood , Nematode Infections*/veterinary , Nematode Infections*/parasitology , Nematode Infections*/drug therapy , Feces*/parasitology , Tropical Climate*, Animals ; Cattle ; Parasite Egg Count ; Anthelmintics/therapeutic use ; Nematoda/isolation & purification ; Nematoda/classification ; Nematoda/drug effects ; Gastrointestinal Diseases/parasitology ; Gastrointestinal Diseases/veterinary ; Intestinal Diseases, Parasitic/veterinary ; Intestinal Diseases, Parasitic/parasitology ; Fenbendazole/therapeutic use |
| مستخلص: | Biomarkers are specific molecular, histological, or physiological characteristics of normal or pathogenic biological processes and are promising in the diagnosis of gastrointestinal nematodes (GINs). Although some biomarkers have been validated for infection by Ostertagia sp. in cattle raised in temperate regions, there is a lack of information for tropical regions. The aim of this project was to assess potential biomarkers and validate the most promising. In the first study, 36 bovines (Nelore breed) naturally infected by GINs were distributed into two groups: infected (not treated with anthelmintic) and treated (treated with fenbendazole on days 0, 7, 14, 21, 28, 42, and 56). The variables of interest were live weight, fecal egg count, hemogram, serum biochemical markers, phosphorus, gastrin, and pepsinogen. In the second step, pepsinogen was assessed in cattle of the Nelore breed distributed among three groups: infected (not treated with anthelmintic), MOX (treated with moxidectin), and IVM + BZD (treated with ivermectin + albendazole). In the first study, no difference between groups was found for weight, albumin, hematocrit (corpuscular volume [CV]), erythrocytes, or hemoglobin. Negative correlations were found between pepsinogen and both CV and albumin, and albumin was negatively correlated with the percentage of Haemonchus sp. in the fecal culture. Among the biomarkers, only pepsinogen differentiated treated and infected (beginning with the 28th day of the study). In the second study, a reduction in pepsinogen was found after anthelmintic treatment. Therefore, pepsinogen is a promising biomarker of worms in cattle naturally infected by the genera Haemonchus and Cooperia in tropical areas. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| معلومات مُعتمدة: | Finance Code 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Finance Code 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Finance Code 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 303950/2021-8 Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| فهرسة مساهمة: | Keywords: Cooperia sp.; Haemonchus sp.; Diagnosis; Pepsinogen |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Anthelmintics) 621BVT9M36 (Fenbendazole) |
| تواريخ الأحداث: | Date Created: 20240507 Date Completed: 20240507 Latest Revision: 20240603 |
| رمز التحديث: | 20240603 |
| DOI: | 10.1007/s00436-024-08228-8 |
| PMID: | 38713234 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1432-1955 |
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| DOI: | 10.1007/s00436-024-08228-8 |