دورية أكاديمية
Honokiol and magnolol: A review of structure-activity relationships of their derivatives.
| العنوان: | Honokiol and magnolol: A review of structure-activity relationships of their derivatives. |
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| المؤلفون: | Dai SY; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, PR China., Qin WX; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, PR China., Yu S; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, PR China., Li C; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, PR China., Yang YH; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, PR China. Electronic address: yangyihui19790508@sina.com., Pei YH; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, PR China. Electronic address: peiyueh@vip163.com. |
| المصدر: | Phytochemistry [Phytochemistry] 2024 Jul; Vol. 223, pp. 114132. Date of Electronic Publication: 2024 May 05. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : London : Elsevier Original Publication: 1961-2003: Oxford : Pergamon Press. |
| مواضيع طبية MeSH: | Lignans*/chemistry , Lignans*/pharmacology , Biphenyl Compounds*/antagonists & inhibitors , Biphenyl Compounds*/pharmacology , Biphenyl Compounds*/chemistry, Structure-Activity Relationship ; Humans ; Molecular Structure ; Allyl Compounds ; Phenols |
| مستخلص: | Honokiol (HK) and magnolol (MAG) are typical representatives of neolignans possessing a wide range of biological activities and are employed as traditional medicines in Asia. In the past few decades, HK and MAG have been proven to be promising chemical scaffolds for the development of novel neolignan drugs. This review focuses on recent advances in the medicinal chemistry of HK and MAG derivatives, especially their structure-activity relationships. In addition, it also presents a comprehensive summary of the pharmacology, biosynthetic pathways, and metabolic characteristics of HK and MAG. This review can provide pharmaceutical chemists deeper insights into medicinal research on HK and MAG, and a reference for the rational design of HK and MAG derivatives. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anti-tumor; Honokiol; Magnolol; Metabolism; Neuroprotection; Structure-activity relationship |
| المشرفين على المادة: | 0 (Lignans) 0 (Biphenyl Compounds) 001E35HGVF (magnolol) 11513CCO0N (honokiol) 0 (Allyl Compounds) 0 (Phenols) |
| تواريخ الأحداث: | Date Created: 20240507 Date Completed: 20240525 Latest Revision: 20240525 |
| رمز التحديث: | 20240526 |
| DOI: | 10.1016/j.phytochem.2024.114132 |
| PMID: | 38714288 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3700 |
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| DOI: | 10.1016/j.phytochem.2024.114132 |