دورية أكاديمية
أعرض في EDS

Respiratory pathogen and clinical features of hospitalized patients in acute exacerbation of chronic obstructive pulmonary disease after COVID 19 pandemic.

التفاصيل البيبلوغرافية
العنوان: Respiratory pathogen and clinical features of hospitalized patients in acute exacerbation of chronic obstructive pulmonary disease after COVID 19 pandemic.
المؤلفون: Kim SJ; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.; Lung Research Institute, Hallym University College of Medicine, Chuncheon, Korea., Kim T; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.; Lung Research Institute, Hallym University College of Medicine, Chuncheon, Korea., Choi H; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.; Lung Research Institute, Hallym University College of Medicine, Chuncheon, Korea., Shin TR; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.; Lung Research Institute, Hallym University College of Medicine, Chuncheon, Korea., Kim HI; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang-si, Korea.; Lung Research Institute, Hallym University College of Medicine, Chuncheon, Korea., Jang SH; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang-si, Korea.; Lung Research Institute, Hallym University College of Medicine, Chuncheon, Korea., Hong JY; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon-si, Korea.; Lung Research Institute, Hallym University College of Medicine, Chuncheon, Korea., Lee CY; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon-si, Korea.; Lung Research Institute, Hallym University College of Medicine, Chuncheon, Korea., Chung S; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Dongtan-si, Korea.; Lung Research Institute, Hallym University College of Medicine, Chuncheon, Korea., Choi JH; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Dongtan-si, Korea.; Lung Research Institute, Hallym University College of Medicine, Chuncheon, Korea., Sim YS; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea. sysliver@naver.com.; Lung Research Institute, Hallym University College of Medicine, Chuncheon, Korea. sysliver@naver.com.
المصدر: Scientific reports [Sci Rep] 2024 May 07; Vol. 14 (1), pp. 10462. Date of Electronic Publication: 2024 May 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: COVID-19*/epidemiology , COVID-19*/complications , Pulmonary Disease, Chronic Obstructive*/epidemiology , Pulmonary Disease, Chronic Obstructive*/complications , Hospitalization*, Humans ; Aged ; Male ; Female ; Aged, 80 and over ; SARS-CoV-2/isolation & purification ; Middle Aged ; Pandemics ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; Disease Progression ; Retrospective Studies ; Streptococcus pneumoniae/isolation & purification ; Streptococcus pneumoniae/pathogenicity ; Haemophilus influenzae/isolation & purification
مستخلص: Respiratory infections are common causes of acute exacerbation of chronic obstructive lung disease (AECOPD). We explored whether the pathogens causing AECOPD and clinical features changed from before to after the coronavirus disease 2019 (COVID-19) outbreak. We reviewed the medical records of patients hospitalized with AECOPD at four university hospitals between January 2017 and December 2018 and between January 2021 and December. We evaluated 1180 patients with AECOPD for whom medication histories were available. After the outbreak, the number of patients hospitalized with AECOPD was almost 44% lower compared with before the outbreak. Patients hospitalized with AECOPD after the outbreak were younger (75 vs. 77 years, p = 0.003) and more often stayed at home (96.6% vs. 88.6%, p < 0.001) than patients of AECOPD before the outbreak. Hospital stay was longer after the outbreak than before the outbreak (10 vs. 8 days. p < 0.001). After the COVID-19 outbreak, the identification rates of S. pneumoniae (15.3 vs. 6.2%, p < 0.001) and Hemophilus influenzae (6.4 vs. 2.4%, p = 0.002) decreased, whereas the identification rates of P. aeruginosa (9.4 vs. 13.7%, p = 0.023), Klebsiella pneumoniae (5.3 vs. 9.8%, p = 0.004), and methicillin-resistant Staphylococcus aureus (1.0 vs. 2.8%, p = 0.023) increased. After the outbreak, the identification rate of influenza A decreased (10.4 vs. 1.0%, p = 0.023). After the outbreak, the number of patients hospitalized with AECOPD was lower and the identification rates of community-transmitted pathogens tended to decrease, whereas the rates of pathogens capable of chronic colonization tended to increase. During the period of large-scale viral outbreaks that require quarantine, patients with AECOPD might be given more consideration for treatment against strains that can colonize chronic respiratory disease rather than community acquired pathogens.
(© 2024. The Author(s).)
References: Nat Commun. 2022 Oct 8;13(1):5930. (PMID: 36209210)
JAMA Netw Open. 2022 Mar 1;5(3):e222933. (PMID: 35297972)
PLoS One. 2022 Jan 6;17(1):e0262347. (PMID: 34990489)
Tuberc Respir Dis (Seoul). 2018 Oct;81(4):261-273. (PMID: 29926554)
Am J Respir Crit Care Med. 2022 Jun 1;205(11):1271-1280. (PMID: 35192447)
Chronic Obstr Pulm Dis. 2015;2(3):252-258. (PMID: 28626792)
Respirology. 2017 May;22(4):634-650. (PMID: 28342288)
Open Forum Infect Dis. 2020 Jan 04;7(1):ofz546. (PMID: 31993457)
Lancet Digit Health. 2021 Jun;3(6):e360-e370. (PMID: 34045002)
Curr Opin Pulm Med. 2009 Mar;15(2):138-42. (PMID: 19532029)
Chronic Obstr Pulm Dis. 2021 Oct 28;8(4):572-579. (PMID: 34592084)
JAMA. 2020 Jul 7;324(1):96-99. (PMID: 32501493)
Respiration. 2012;84(1):36-43. (PMID: 21996555)
Respiration. 2018;96(5):417-424. (PMID: 30041176)
BMC Med. 2021 May 17;19(1):124. (PMID: 33993870)
Am J Respir Crit Care Med. 2006 May 1;173(9):991-8. (PMID: 16474030)
Nat Rev Microbiol. 2018 Jun;16(6):355-367. (PMID: 29599457)
Science. 2021 Aug 27;373(6558):. (PMID: 34446582)
Am J Respir Crit Care Med. 2008 Oct 15;178(8):814-21. (PMID: 18669817)
Science. 2021 Jun 4;372(6546):1043-1044. (PMID: 34083477)
Thorax. 2021 May;76(5):512-513. (PMID: 33273024)
Microb Pathog. 2017 Dec;113:190-196. (PMID: 29038056)
Nat Commun. 2021 Feb 12;12(1):1001. (PMID: 33579926)
N Engl J Med. 2008 Nov 27;359(22):2355-65. (PMID: 19038881)
Am J Transplant. 2020 Dec;20(12):3681-3685. (PMID: 33264506)
فهرسة مساهمة: Keywords: COVID-19; Chronic obstructive pulmonary disease; Respiratory pathogen
تواريخ الأحداث: Date Created: 20240507 Date Completed: 20240508 Latest Revision: 20240510
رمز التحديث: 20240510
مُعرف محوري في PubMed: PMC11076476
DOI: 10.1038/s41598-024-61360-4
PMID: 38714885
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-61360-4