دورية أكاديمية
The gut microbiome and HLA-B27-associated anterior uveitis: a case-control study.
| العنوان: | The gut microbiome and HLA-B27-associated anterior uveitis: a case-control study. |
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| المؤلفون: | Morandi SC; Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. sophia.c.morandi@gmail.com.; Department for BioMedical Research, University of Bern, Bern, Switzerland. sophia.c.morandi@gmail.com., Herzog EL; Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland., Munk M; Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Kreuzer M; Department for BioMedical Research, University of Bern, Bern, Switzerland.; Interfaculty Bioinformatics Unit, University of Bern, Bern, Switzerland., Largiadèr CR; Department of Clinical Chemistry, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland., Wolf S; Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland., Zinkernagel M; Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland., Zysset-Burri DC; Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland. |
| المصدر: | Journal of neuroinflammation [J Neuroinflammation] 2024 May 07; Vol. 21 (1), pp. 120. Date of Electronic Publication: 2024 May 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, c2004- |
| مواضيع طبية MeSH: | HLA-B27 Antigen*/genetics , HLA-B27 Antigen*/immunology , Gastrointestinal Microbiome*/physiology , Uveitis, Anterior*/microbiology , Uveitis, Anterior*/immunology, Humans ; Female ; Male ; Middle Aged ; Adult ; Case-Control Studies ; Aged |
| مستخلص: | Background: The human gut microbiome (GM) is involved in inflammation and immune response regulation. Dysbiosis, an imbalance in this ecosystem, facilitates pathogenic invasion, disrupts immune equilibrium, and potentially triggers diseases including various human leucocyte antigen (HLA)-B27-associated autoinflammatory and autoimmune diseases such as inflammatory bowel disease (IBD) and spondyloarthropathy (SpA). This study assesses compositional and functional alterations of the GM in patients with HLA-B27-associated non-infectious anterior uveitis (AU) compared to healthy controls. Methods: The gut metagenomes of 20 patients with HLA-B27-associated non-infectious AU, 21 age- and sex-matched HLA-B27-negative controls, and 6 HLA-B27-positive healthy controls without a history of AU were sequenced using the Illumina NovaSeq 6000 platform for whole metagenome shotgun sequencing. To identify taxonomic and functional features with significantly different relative abundances between groups and to identify associations with clinical metadata, the multivariate association by linear models (MaAsLin) R package was applied. Results: Significantly higher levels of the Eubacterium ramulus species were found in HLA-B27-negative controls (p = 0.0085, Mann-Whitney U-test). No significant differences in microbial composition were observed at all other taxonomic levels. Functionally, the lipid IV Conclusion: In our cohort, non-infectious AU development is associated with compositional and functional alterations of the GM. Further research is needed to assess the causality of these associations, offering potentially novel therapeutic strategies. (© 2024. The Author(s).) |
| References: | Trends Microbiol. 2023 Feb;31(2):142-158. (PMID: 36058784) Gut. 2020 Aug;69(8):1510-1519. (PMID: 32409589) Front Immunol. 2021 Jan 05;11:608134. (PMID: 33469457) Inflamm Bowel Dis. 2007 Mar;13(3):317-24. (PMID: 17206701) J Exp Med. 1994 Dec 1;180(6):2359-64. (PMID: 7964509) Infect Immun. 2001 Oct;69(10):6044-54. (PMID: 11553542) Ther Adv Musculoskelet Dis. 2020 Jul 9;12:1759720X20939410. (PMID: 32695235) Inflamm Bowel Dis. 2009 Feb;15(2):199-205. (PMID: 18618670) PLoS Comput Biol. 2012;8(6):e1002358. (PMID: 22719234) Nat Methods. 2012 Jun 10;9(8):811-4. (PMID: 22688413) Am J Ophthalmol. 2005 Sep;140(3):509-16. (PMID: 16196117) Nat Commun. 2020 Jan 17;11(1):362. (PMID: 31953381) Ophthalmol Ther. 2020 Sep;9(3):499-513. (PMID: 32617914) Microb Biotechnol. 2020 Nov;13(6):2032-2043. (PMID: 32969200) J Leukoc Biol. 2019 Oct;106(4):879-887. (PMID: 31287586) Sci Rep. 2019 Oct 25;9(1):15303. (PMID: 31653902) Arthritis Rheumatol. 2019 Oct;71(10):1642-1650. (PMID: 31038287) Appl Environ Microbiol. 2019 Sep 17;85(19):. (PMID: 31375488) PLoS Comput Biol. 2021 Nov 16;17(11):e1009442. (PMID: 34784344) Children (Basel). 2022 Apr 16;9(4):. (PMID: 35455612) Prog Retin Eye Res. 2023 Jan;92:101117. (PMID: 36075807) Gastroenterology. 2017 Sep;153(3):711-722. (PMID: 28596023) Inflamm Bowel Dis. 2006 May;12(5):389-94. (PMID: 16670528) Ann Oncol. 2020 Apr;31(4):525-531. (PMID: 32115349) Arthritis Rheumatol. 2024 Jan;76(1):48-58. (PMID: 37471465) NPJ Genom Med. 2020 Sep 1;5:34. (PMID: 32922859) Mediators Inflamm. 2020 Nov 7;2020:8884324. (PMID: 33204218) Front Microbiol. 2022 Sep 26;13:999001. (PMID: 36225386) Molecules. 2020 Nov 11;25(22):. (PMID: 33187049) Nature. 1974 Apr 19;248(5450):701-2. (PMID: 4133807) World J Gastroenterol. 2019 May 14;25(18):2162-2176. (PMID: 31143068) Ann Rheum Dis. 2020 Jan;79(1):132-140. (PMID: 31662318) Reprod Sci. 2023 Jul;30(7):2210-2218. (PMID: 36656424) Nature. 1980 Aug 7;286(5773):611-3. (PMID: 7402339) Nat Rev Microbiol. 2010 Jan;8(1):8-14. (PMID: 19946286) Cell Mol Immunol. 2022 Jul;19(7):791-804. (PMID: 35545662) Arthritis Rheumatol. 2023 Jan;75(1):41-52. (PMID: 35818337) Appl Environ Microbiol. 2023 Jul 26;89(7):e0078923. (PMID: 37338379) Nature. 2007 Oct 18;449(7164):804-10. (PMID: 17943116) BMJ. 2018 Jan 8;360:j5145. (PMID: 29311119) Gastroenterology. 2023 Jan;164(1):103-116. (PMID: 36240952) Nat Commun. 2015 Oct 23;6:8642. (PMID: 26494419) Comput Struct Biotechnol J. 2013 Apr 05;5:e201302012. (PMID: 24688705) Br J Ophthalmol. 2004 Sep;88(9):1159-62. (PMID: 15317708) Nat Rev Rheumatol. 2018 Dec;14(12):704-713. (PMID: 30301938) Immunity. 2015 Aug 18;43(2):343-53. (PMID: 26287682) Nature. 2011 May 12;473(7346):174-80. (PMID: 21508958) Cell. 2006 Feb 24;124(4):837-48. (PMID: 16497592) Prog Retin Eye Res. 2012 Mar;31(2):182-94. (PMID: 22120610) PLoS One. 2014 Aug 20;9(8):e105684. (PMID: 25140823) Orphanet J Rare Dis. 2012 Aug 29;7:57. (PMID: 22932001) JAMA Ophthalmol. 2016 Nov 01;134(11):1237-1245. (PMID: 27608193) Am J Ophthalmol. 2018 May;189:77-85. (PMID: 29505775) Clin Chim Acta. 2003 Sep;335(1-2):9-20. (PMID: 12927679) Front Med (Lausanne). 2021 Sep 10;8:695904. (PMID: 34568364) Nat Microbiol. 2022 Feb;7(2):262-276. (PMID: 35087228) Br J Ophthalmol. 2010 Mar;94(3):271-4. (PMID: 19264730) Ann Rheum Dis. 2017 Sep;76(9):1614-1622. (PMID: 28606969) |
| معلومات مُعتمدة: | YTCR 24/22 Gottfried und Julia Bangerter-Rhyner-Stiftung |
| فهرسة مساهمة: | Keywords: Bacteroides caccae; Eubacterium ramulus; Phocaeicola vulgatus; Anterior uveitis; Gut microbiome; HLA-B27; Lipid IVA biosynthesis; Whole metagenome shotgun sequencing |
| المشرفين على المادة: | 0 (HLA-B27 Antigen) |
| تواريخ الأحداث: | Date Created: 20240507 Date Completed: 20240508 Latest Revision: 20240528 |
| رمز التحديث: | 20240529 |
| مُعرف محوري في PubMed: | PMC11077820 |
| DOI: | 10.1186/s12974-024-03109-4 |
| PMID: | 38715051 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1742-2094 |
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| DOI: | 10.1186/s12974-024-03109-4 |