دورية أكاديمية
The gut microbiome and HLA-B27-associated anterior uveitis: a case-control study.
العنوان: | The gut microbiome and HLA-B27-associated anterior uveitis: a case-control study. |
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المؤلفون: | Morandi SC; Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. sophia.c.morandi@gmail.com.; Department for BioMedical Research, University of Bern, Bern, Switzerland. sophia.c.morandi@gmail.com., Herzog EL; Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland., Munk M; Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Kreuzer M; Department for BioMedical Research, University of Bern, Bern, Switzerland.; Interfaculty Bioinformatics Unit, University of Bern, Bern, Switzerland., Largiadèr CR; Department of Clinical Chemistry, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland., Wolf S; Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland., Zinkernagel M; Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland., Zysset-Burri DC; Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland. |
المصدر: | Journal of neuroinflammation [J Neuroinflammation] 2024 May 07; Vol. 21 (1), pp. 120. Date of Electronic Publication: 2024 May 07. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : BioMed Central, c2004- |
مواضيع طبية MeSH: | HLA-B27 Antigen*/genetics , HLA-B27 Antigen*/immunology , Gastrointestinal Microbiome*/physiology , Uveitis, Anterior*/microbiology , Uveitis, Anterior*/immunology, Humans ; Female ; Male ; Middle Aged ; Adult ; Case-Control Studies ; Aged |
مستخلص: | Background: The human gut microbiome (GM) is involved in inflammation and immune response regulation. Dysbiosis, an imbalance in this ecosystem, facilitates pathogenic invasion, disrupts immune equilibrium, and potentially triggers diseases including various human leucocyte antigen (HLA)-B27-associated autoinflammatory and autoimmune diseases such as inflammatory bowel disease (IBD) and spondyloarthropathy (SpA). This study assesses compositional and functional alterations of the GM in patients with HLA-B27-associated non-infectious anterior uveitis (AU) compared to healthy controls. Methods: The gut metagenomes of 20 patients with HLA-B27-associated non-infectious AU, 21 age- and sex-matched HLA-B27-negative controls, and 6 HLA-B27-positive healthy controls without a history of AU were sequenced using the Illumina NovaSeq 6000 platform for whole metagenome shotgun sequencing. To identify taxonomic and functional features with significantly different relative abundances between groups and to identify associations with clinical metadata, the multivariate association by linear models (MaAsLin) R package was applied. Results: Significantly higher levels of the Eubacterium ramulus species were found in HLA-B27-negative controls (p = 0.0085, Mann-Whitney U-test). No significant differences in microbial composition were observed at all other taxonomic levels. Functionally, the lipid IV Conclusion: In our cohort, non-infectious AU development is associated with compositional and functional alterations of the GM. Further research is needed to assess the causality of these associations, offering potentially novel therapeutic strategies. (© 2024. The Author(s).) |
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معلومات مُعتمدة: | YTCR 24/22 Gottfried und Julia Bangerter-Rhyner-Stiftung |
فهرسة مساهمة: | Keywords: Bacteroides caccae; Eubacterium ramulus; Phocaeicola vulgatus; Anterior uveitis; Gut microbiome; HLA-B27; Lipid IVA biosynthesis; Whole metagenome shotgun sequencing |
المشرفين على المادة: | 0 (HLA-B27 Antigen) |
تواريخ الأحداث: | Date Created: 20240507 Date Completed: 20240508 Latest Revision: 20240528 |
رمز التحديث: | 20240529 |
مُعرف محوري في PubMed: | PMC11077820 |
DOI: | 10.1186/s12974-024-03109-4 |
PMID: | 38715051 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1742-2094 |
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DOI: | 10.1186/s12974-024-03109-4 |