دورية أكاديمية
Salivary excretion of systemically injected [ 18 F]DCFPyL in prostate cancer patients undergoing PSMA scans.
| العنوان: | Salivary excretion of systemically injected [ 18 F]DCFPyL in prostate cancer patients undergoing PSMA scans. |
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| المؤلفون: | Fernandes B; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States., Roy J; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States., Basuli F; Chemistry and Synthesis Center, National Heart, Lung and Blood Institute, Bethesda, MD, United States., Warner BM; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United States., Lindenberg L; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States., Mena E; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States., Adler SS; Clinical Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, United States., Griffiths GL; Clinical Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, United States., Choyke PL; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States., Lin FI; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States. |
| المصدر: | Frontiers in oncology [Front Oncol] 2024 Apr 23; Vol. 14, pp. 1367962. Date of Electronic Publication: 2024 Apr 23 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مستخلص: | Introduction: Prostate-specific membrane antigen (PSMA) is present in high amounts in salivary glands, but it is unclear whether labeled binders of PSMA are excreted in the saliva. Methods: Ten patients with prostate cancer underwent whole-body [ 18 F]DCFPyL PET/CT (NCT03181867), and saliva samples were collected between 0-120 minutes post-injection. [ 18 F]DCFPyL salivary excretion was measured over 120 minutes and expressed as %ID/g. Protein-associated binding was estimated by the percentage of [ 18 F]DCFPyL versus parent radiotracer. Results: All PET scans of 10 patients (69 ± 8 years) with histologically confirmed prostate cancer (PSA= 2.4 ± 2.4, and Gleason Grade = 6-9) showed high uptake of [ 18 F]-DCFPyL in salivary glands while 8 patients demonstrated high uptake in the saliva at 45 minutes. The intact [ 18 F]-DCFPyL (98%) was also confirmed in the saliva samples at 120 min with increasing salivary radioactivity between 30-120 min. Conclusion: Systemically injected [ 18 F]DCFPyL shows salivary gland uptake, an increasing amount of which is secreted in saliva over time and is not maximized by 120 minutes post-injection. Although probably insignificant for diagnostic studies, patients undergoing PSMA-targeted therapies should be aware of radioactivity in saliva. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Fernandes, Roy, Basuli, Warner, Lindenberg, Mena, Adler, Griffiths, Choyke and Lin.) |
| References: | Nucl Med Biol. 2021 Jul-Aug;98-99:30-39. (PMID: 34020337) Prostate. 2023 Sep;83(12):1186-1192. (PMID: 37211963) Front Oncol. 2020 Nov 05;10:531660. (PMID: 33251129) EJNMMI Res. 2021 Dec 14;11(1):126. (PMID: 34905121) J Nucl Med. 2017 Jun;58(6):942-946. (PMID: 27932557) J Nucl Med. 2022 Aug;63(8):1199-1207. (PMID: 34887335) J Nucl Med. 2021 May 10;62(5):669-674. (PMID: 33008928) |
| فهرسة مساهمة: | Keywords: PET imaging; PSMA; [18F]-DCFPyL; salivary excretion; xerostomia |
| تواريخ الأحداث: | Date Created: 20240508 Latest Revision: 20240509 |
| رمز التحديث: | 20240509 |
| مُعرف محوري في PubMed: | PMC11074343 |
| DOI: | 10.3389/fonc.2024.1367962 |
| PMID: | 38715784 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2234-943X |
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| DOI: | 10.3389/fonc.2024.1367962 |