دورية أكاديمية
أعرض في EDS

Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice.

التفاصيل البيبلوغرافية
العنوان: Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice.
المؤلفون: Ge Y; Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health, San Antonio, TX, USA., Yang C; Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Zadeh M; Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health, San Antonio, TX, USA., Sprague SM; Department of Neurosurgery, University of Texas Health, San Antonio, TX, USA., Lin YD; Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health, San Antonio, TX, USA., Jain HS; Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health, San Antonio, TX, USA., Determann BF 2nd; Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health, San Antonio, TX, USA., Roth WH; Department of Neurology, University of Chicago Medical Center, Chicago, IL, USA., Palavicini JP; Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health, San Antonio, TX, USA., Larochelle J; Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Candelario-Jalil E; Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Mohamadzadeh M; Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health, San Antonio, TX, USA.
المصدر: IScience [iScience] 2024 Mar 14; Vol. 27 (4), pp. 109480. Date of Electronic Publication: 2024 Mar 14 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: Ischemic stroke is the second leading cause of death and disability worldwide, and efforts to prevent stroke, mitigate secondary neurological damage, and promote neurological recovery remain paramount. Recent findings highlight the critical importance of microbiome-related metabolites, including vitamin B12 (VB12), in alleviating toxic stroke-associated neuroinflammation. Here, we showed that VB12 tonically programmed genes supporting microglial cell division and activation and critically controlled cellular fatty acid metabolism in homeostasis. Intriguingly, VB12 promoted mitochondrial transcriptional and metabolic activities and significantly restricted stroke-associated gene alterations in microglia. Furthermore, VB12 differentially altered the functions of microglial subsets during the acute phase of ischemic stroke, resulting in reduced brain damage and improved neurological function. Pharmacological depletion of microglia before ischemic stroke abolished VB12-mediated neurological improvement. Thus, our preclinical studies highlight the relevance of VB12 in the functional programming of microglia to alleviate neuroinflammation, minimize ischemic injury, and improve host neurological recovery after ischemic stroke.
Competing Interests: The authors declare no competing interests.
(© 2024 The Authors.)
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معلومات مُعتمدة: P30 AG013319 United States AG NIA NIH HHS; R01 AI154630 United States AI NIAID NIH HHS; R01 DK109560 United States DK NIDDK NIH HHS; R01 NS109816 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: Immunology; Neuroscience; Omics; Transcriptomics
تواريخ الأحداث: Date Created: 20240508 Latest Revision: 20240625
رمز التحديث: 20240625
مُعرف محوري في PubMed: PMC11075062
DOI: 10.1016/j.isci.2024.109480
PMID: 38715940
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2024.109480