دورية أكاديمية
أعرض في EDS

Ameliorative effects of Tagetes erecta Linn. flower against desiccation stress-induced dry eye symptoms in the mice model.

التفاصيل البيبلوغرافية
العنوان: Ameliorative effects of Tagetes erecta Linn. flower against desiccation stress-induced dry eye symptoms in the mice model.
المؤلفون: Lee H; Department of Convergence Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea., Hwangbo H; Anti-Aging Research Center, Dong-eui University, Busan, Republic of Korea.; Department of Biochemistry, College of Korean Medicine, Dong-eui University, Busan, Republic of Korea., Hyun JW; Department of Biochemistry, College of Medicine, Jeju National University, Jeju, Republic of Korea.; Jeju Research Center for Natural Medicine, Jeju National University, Jeju, Republic of Korea., Shim JH; Department of Biomedicine, Health & Life Convergence Sciences, BK21 Four, College of Pharmacy, Mokpo National University, Muan, Republic of Korea.; Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Republic of Korea., Leem SH; Department of Biomedical Sciences, Dong-A University, Busan, Republic of Korea.; Department of Health Sciences, The Graduated of Dong-A University, Busan, Republic of Korea., Kim GY; Department of Marine Life Science, Jeju National University, Jeju, Republic of Korea., Choi YH; Anti-Aging Research Center, Dong-eui University, Busan, Republic of Korea.; Department of Biochemistry, College of Korean Medicine, Dong-eui University, Busan, Republic of Korea.
المصدر: Integrative medicine research [Integr Med Res] 2024 Jun; Vol. 13 (2), pp. 101038. Date of Electronic Publication: 2024 Mar 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101612707 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2213-4220 (Print) Linking ISSN: 22134220 NLM ISO Abbreviation: Integr Med Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier
مستخلص: Background: Tagetes erecta Linn, popularly known as Marigold, has various pharmacological effects. It is used as a dietary supplement, especially for the posterior segment of the eye. However, the effect of T. erecta Linn on ocular disorders is still unknown. The purpose of this study was to investigate the effect of oral administration of ethanol extract of T. erecta Linn flower (TE) for dry eye syndrome (DED) in a murine model.
Methods: Twenty-four mice were subjected to desiccation stress (DS) to induce DED and subcutaneous injection of scopolamine hydrobromide was administered 4 times a day for 21 days. TE and cyclosporine A (CsA) were administered for an additional 14 days under DS conditions. Mice were randomly divided into four groups: control, TE200, TE400, and CsA. Changes in tear production and corneal fluorescein staining were measured at baseline, after 7 days of DS, and after treatment for 7 and 14 days.
Results: DS significantly decreased tear production and increased corneal fluorescein score; the parameters were significantly reversed in the TE400 (oral administration of 400 mg TE/kg body weight) group. TE markedly improved DS-induced changes including corneal epithelial detachment and lacrimal gland inflammation. The anti-inflammatory effect of TE 400 supplementation was similar to that of CsA.
Conclusions: Our findings suggest that oral administration of TE may protect against DS-induced DED via stabilization of the tear film and suppression of inflammation. This study provides an experimental basis for further studies on the potential clinical use of TE in preventing DED.
(© 2024 Korea Institute of Oriental Medicine. Published by Elsevier B.V.)
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فهرسة مساهمة: Keywords: Desiccation stress; Dry eye disease; Inflammation; Lacrimal gland; Tagetes erecta linn
تواريخ الأحداث: Date Created: 20240508 Latest Revision: 20240509
رمز التحديث: 20240509
مُعرف محوري في PubMed: PMC11070322
DOI: 10.1016/j.imr.2024.101038
PMID: 38716164
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-4220
DOI:10.1016/j.imr.2024.101038