دورية أكاديمية
An Epidemiological Investigation of Lassa Fever Outbreak in Ebonyi State South Eastern Nigeria Lessons Learnt (January to March 2018).
| العنوان: | An Epidemiological Investigation of Lassa Fever Outbreak in Ebonyi State South Eastern Nigeria Lessons Learnt (January to March 2018). |
|---|---|
| المؤلفون: | Agboeze J; Department of Internal Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki Nigeria., Nwali MI; Department of Internal Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki Nigeria., Ajayi N; Department of Internal Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki Nigeria., Chika-Igwenyi NM; Department of Internal Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki Nigeria. |
| المصدر: | Nigerian medical journal : journal of the Nigeria Medical Association [Niger Med J] 2022 May 13; Vol. 62 (5), pp. 279-283. Date of Electronic Publication: 2022 May 13 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nigerian Medical Association Country of Publication: Nigeria NLM ID: 0315137 Publication Model: eCollection Cited Medium: Print ISSN: 0300-1652 (Print) Linking ISSN: 03001652 NLM ISO Abbreviation: Niger Med J Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Abuja, Nigeria : Nigerian Medical Association Original Publication: Lagos : Literamed Publications (Nig.) Ltd. |
| مستخلص: | Background: We investigated an outbreak of Lassa fever that occurred in Ebonyi state, Southeast Nigeria from January to March 2018. Methodology: The Emergency operational centre (EOC) model was used for the outbreak coordination. Cases and deaths were identified through the routine surveillance system. Blood specimens collected from suspected cases were sent for confirmation at the Virology Centre, Alex Ekwueme Federal University Teaching Hospital, Abakaliki (AEFUTHA). Active case search was instituted, and identified contacts of confirmed cases were followed up for the maximum incubation period of the disease. Other public health responses included infection prevention and control, communication and advocacy as well as case management. Data collected were analysed using the Epi info statistical software package. Results: We identified 89 suspected Lassa Fever (LF) cases out of which 61 were confirmed. The mean age was 35±16.2 and the age group mostly affected was 30-39 years. More than half (59.7%) of the confirmed cases were females. The Case Fatality Rate (CFR) was 26.2% among the laboratory confirmed cases. Five of the deaths occurred among health care workers. Out of 325 contacts of the confirmed cases, 304(99.7%) completed the follow-up and only 1(0.3%) of them developed symptoms consistent with LF and was confirmed by the laboratory. Conclusions: The high CFR in those presenting late to the hospital underscores the need for intensive public enlightenment that encourages early presentation to hospital. Majority of the confirmed cases were primary cases, hence efforts should be intensified in breaking the chain of transmission in the animal-man interphase. Death of healthcare workers involved in management of Lassa fever raises the importance of providing life insurance for concerned healthcare workers. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021 Nigerian Medical Association.) |
| References: | Int J Infect Dis. 2013 Nov;17(11):e1011-6. (PMID: 23871405) Trop Med Int Health. 2015 Nov;20(11):1424-1430. (PMID: 26171669) J Virol. 2000 Aug;74(15):6992-7004. (PMID: 10888638) Vaccine. 2016 Oct 10;34(43):5175-5180. (PMID: 27378681) Lancet Infect Dis. 2018 Jun;18(6):684-695. (PMID: 29523497) BMJ. 1995 Sep 30;311(7009):857-9. (PMID: 7580496) Crit Rev Clin Lab Sci. 2004;41(4):339-90. (PMID: 15487592) PLoS Negl Trop Dis. 2009;3(3):e388. (PMID: 19255625) MMWR Morb Mortal Wkly Rep. 2014 Oct 3;63(39):867-72. (PMID: 25275332) PLoS Negl Trop Dis. 2018 Nov 6;12(11):e0006829. (PMID: 30399142) N Engl J Med. 2014 Oct 16;371(16):1481-95. (PMID: 25244186) PLoS Negl Trop Dis. 2012;6(9):e1839. (PMID: 23029594) Trans R Soc Trop Med Hyg. 2010 Jan;104(1):51-4. (PMID: 19712954) |
| فهرسة مساهمة: | Keywords: Emergency operational centre; Lassa Fever; Nigeria; Outbreak Response |
| تواريخ الأحداث: | Date Created: 20240508 Latest Revision: 20240509 |
| رمز التحديث: | 20240509 |
| مُعرف محوري في PubMed: | PMC11073840 |
| DOI: | 10.60787/NMJ-62-5-55 |
| PMID: | 38716434 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0300-1652 |
|---|---|
| DOI: | 10.60787/NMJ-62-5-55 |