دورية أكاديمية
أعرض في EDS

Head Injury and Risk of Incident Ischemic Stroke in Community-Dwelling Adults.

التفاصيل البيبلوغرافية
العنوان: Head Injury and Risk of Incident Ischemic Stroke in Community-Dwelling Adults.
المؤلفون: Elser H; Department of Neurology (H.E., L.W.P., R.D.-A., S.E.K., A.L.C.S.), University of Pennsylvania, Philadelphia., Pappalardo LW; Department of Neurology (H.E., L.W.P., R.D.-A., S.E.K., A.L.C.S.), University of Pennsylvania, Philadelphia., Gottesman RF; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (R.F.G.)., Coresh J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (J.C., S.K.)., Diaz-Arrastia R; Department of Neurology (H.E., L.W.P., R.D.-A., S.E.K., A.L.C.S.), University of Pennsylvania, Philadelphia., Mosley TH; The Memory Impairment and Neurodegenerative Dementia Center, University of Mississippi Medical Center, Jackson (T.H.M.)., Kasner SE; Department of Neurology (H.E., L.W.P., R.D.-A., S.E.K., A.L.C.S.), University of Pennsylvania, Philadelphia., Koton S; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (J.C., S.K.).; School of Health Professions, Tel Aviv University, Israel (S.K.)., Schneider ALC; Department of Neurology (H.E., L.W.P., R.D.-A., S.E.K., A.L.C.S.), University of Pennsylvania, Philadelphia.; Department of Biostatistics, Epidemiology, and Informatics, School of Medicine (A.L.C.S.), University of Pennsylvania, Philadelphia.
المصدر: Stroke [Stroke] 2024 Jun; Vol. 55 (6), pp. 1562-1571. Date of Electronic Publication: 2024 May 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: MEDLINE
أسماء مطبوعة: Publication: 1998- : Baltimore, Md. : Lippincott Williams & Wilkins
Original Publication: Dallas : American Heart Association
مواضيع طبية MeSH: Ischemic Stroke*/epidemiology , Independent Living* , Craniocerebral Trauma*/epidemiology, Humans ; Female ; Male ; Middle Aged ; Incidence ; Risk Factors ; Adult ; Prospective Studies ; Aged ; Cohort Studies
مستخلص: Background: While stroke is a recognized short-term sequela of traumatic brain injury, evidence about long-term ischemic stroke risk after traumatic brain injury remains limited.
Methods: The Atherosclerosis Risk in Communities Study is an ongoing prospective cohort comprised of US community-dwelling adults enrolled in 1987 to 1989 followed through 2019. Head injury was defined using self-report and hospital-based diagnostic codes and was analyzed as a time-varying exposure. Incident ischemic stroke events were physician-adjudicated. We used Cox regression adjusted for sociodemographic and cardiovascular risk factors to estimate the hazard of ischemic stroke as a function of head injury. Secondary analyses explored the number and severity of head injuries; the mechanism and severity of incident ischemic stroke; and heterogeneity within subgroups defined by race, sex, and age.
Results: Our analysis included 12 813 participants with no prior head injury or stroke. The median follow-up age was 27.1 years (25th-75th percentile=21.1-30.5). Participants were of median age 54 years (25th-75th percentile=49-59) at baseline; 57.7% were female and 27.8% were Black. There were 2158 (16.8%) participants with at least 1 head injury and 1141 (8.9%) participants with an incident ischemic stroke during follow-up. For those with head injuries, the median age to ischemic stroke was 7.5 years (25th-75th percentile=2.2-14.0). In adjusted models, head injury was associated with an increased hazard of incident ischemic stroke (hazard ratio [HR], 1.34 [95% CI, 1.12-1.60]). We observed evidence of dose-response for the number of head injuries (1: HR, 1.16 [95% CI, 0.97-1.40]; ≥2: HR, 1.94 [95% CI, 1.39-2.71]) but not for injury severity. We observed evidence of stronger associations between head injury and more severe stroke (National Institutes of Health Stroke Scale score ≤5: HR, 1.31 [95% CI, 1.04-1.64]; National Institutes of Health Stroke Scale score 6-10: HR, 1.64 [95% CI, 1.06-2.52]; National Institutes of Health Stroke Scale score ≥11: HR, 1.80 [95% CI, 1.18-2.76]). Results were similar across stroke mechanism and within strata of race, sex, and age.
Conclusions: In this community-based cohort, head injury was associated with subsequent ischemic stroke. These results suggest the importance of public health interventions aimed at preventing head injuries and primary stroke prevention among individuals with prior traumatic brain injuries.
Competing Interests: Disclosures During the conduct of this study, Drs. Gottesman and Schneider served as Associate Editors for the journal Neurology at the American Academy of Neurology. Dr Coresh received grants from National Institutes of Health (NIH) unrelated to this study. Dr Mosley received grants from NIH unrelated to this study. Dr Kasner received personal fees from Bristol Myers Squibb, DiaMedica Therapeutics, and AbbVie and grants from Genentech unrelated to this study. The other authors report no conflicts.
التعليقات: Erratum in: Stroke. 2024 Jun 26. doi: 10.1161/STR.0000000000000472. (PMID: 38924482)
References: Int J Environ Res Public Health. 2017 Feb 25;14(3):. (PMID: 28245607)
Stroke. 1999 Apr;30(4):736-43. (PMID: 10187871)
JAMA. 2014 Jul 16;312(3):259-68. (PMID: 25027141)
J Stroke. 2020 Sep;22(3):357-368. (PMID: 33053951)
Neurology. 2013 Jul 2;81(1):33-9. (PMID: 23803315)
Sci Rep. 2022 Jul 19;12(1):12338. (PMID: 35853922)
Neuron. 2019 Aug 7;103(3):367-379. (PMID: 31394062)
JAMA Neurol. 2021 Aug 1;78(8):982-992. (PMID: 34228047)
JAMA Neurol. 2023 Mar 1;80(3):260-269. (PMID: 36689218)
J Head Trauma Rehabil. 2015 Mar-Apr;30(2):E62-7. (PMID: 24816156)
JAMA Neurol. 2021 Sep 1;78(9):1137-1148. (PMID: 34279565)
JAMA Netw Open. 2022 Apr 1;5(4):e229478. (PMID: 35482306)
Brain Inj. 2013 Jun;27(6):640-50. (PMID: 23514276)
Brain Inj. 2020 Dec 5;34(13-14):1763-1770. (PMID: 33280404)
Am J Clin Nutr. 1982 Nov;36(5):936-42. (PMID: 7137077)
Brain. 2013 Jan;136(Pt 1):28-42. (PMID: 23365092)
JAMA Neurol. 2022 Nov 1;79(11):1122-1129. (PMID: 36066882)
Am J Epidemiol. 1989 Apr;129(4):687-702. (PMID: 2646917)
Clin Neuropsychol. 2018 Apr;32(3):524-529. (PMID: 28988512)
Mayo Clin Proc. 2014 Feb;89(2):163-72. (PMID: 24485130)
Natl Health Stat Report. 2016 Jan 22;(89):1-20. (PMID: 26828779)
Exp Neurol. 2016 Jan;275 Pt 3:353-366. (PMID: 26048614)
Neuroepidemiology. 2013;40(2):109-16. (PMID: 23095721)
Scand J Trauma Resusc Emerg Med. 2014 Nov 19;22:66. (PMID: 25406859)
J Neurosurg. 2018 Apr 27;130(4):1080-1097. (PMID: 29701556)
Front Neurosci. 2022 Feb 10;16:814684. (PMID: 35221904)
Front Cell Neurosci. 2019 Aug 08;13:307. (PMID: 31440141)
J Stroke Cerebrovasc Dis. 2005 Nov-Dec;14(6):281-3. (PMID: 17904038)
J Am Coll Cardiol. 2021 Jun 15;77(23):2939-2959. (PMID: 34112321)
N Engl J Med. 2018 Sep 20;379(12):1176-1178. (PMID: 30231228)
Stroke. 2023 Aug;54(8):2059-2068. (PMID: 37334708)
Neurology. 2021 Jul 13;97(2):e124-e135. (PMID: 34039721)
Stroke. 2011 Oct;42(10):2733-9. (PMID: 21799162)
JAMA Neurol. 2019 Sep 01;76(9):1049-1059. (PMID: 31157856)
World Neurosurg. 2019 Feb;122:e740-e753. (PMID: 30391613)
Int J Epidemiol. 2018 Feb 1;47(1):236-245. (PMID: 29024978)
Lancet Neurol. 2017 Oct;16(10):813-825. (PMID: 28920887)
Neurohospitalist. 2017 Jul;7(3):122-126. (PMID: 28634501)
MMWR Surveill Summ. 2003 Jun 27;52(4):1-20. (PMID: 12836629)
MMWR Surveill Summ. 2017 Mar 17;66(9):1-16. (PMID: 28301451)
معلومات مُعتمدة: K23 NS123340 United States NS NINDS NIH HHS; U01 HL096812 United States HL NHLBI NIH HHS; 75N92022D00002 United States HL NHLBI NIH HHS; U01 HL096917 United States HL NHLBI NIH HHS; U01 HL096902 United States HL NHLBI NIH HHS; 75N92022D00004 United States HL NHLBI NIH HHS; U01 HL096814 United States HL NHLBI NIH HHS; 75N92022D00003 United States HL NHLBI NIH HHS; 75N92022D00005 United States HL NHLBI NIH HHS; U01 HL096899 United States HL NHLBI NIH HHS; R25 NS065745 United States NS NINDS NIH HHS; 75N92022D00001 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: brain injuries, traumatic; craniocerebral trauma; heart disease risk factors; ischemic stroke; stroke
تواريخ الأحداث: Date Created: 20240508 Date Completed: 20240524 Latest Revision: 20240626
رمز التحديث: 20240627
مُعرف محوري في PubMed: PMC11126353
DOI: 10.1161/STROKEAHA.123.046443
PMID: 38716662
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4628
DOI:10.1161/STROKEAHA.123.046443