دورية أكاديمية

Hemodynamic Parameters in Spontaneously Hypertensive Rats with Obesity and Chemically Induced Colitis during Probiotic Therapy.

التفاصيل البيبلوغرافية
العنوان: Hemodynamic Parameters in Spontaneously Hypertensive Rats with Obesity and Chemically Induced Colitis during Probiotic Therapy.
المؤلفون: Borshchev YY; Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia., Protsak ES; Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia., Burovenko IY; Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia., Zubkov IG; Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia., Galagudza MM; Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia. galagudza@almazovcentre.ru.
المصدر: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Mar; Vol. 176 (5), pp. 543-547. Date of Electronic Publication: 2024 May 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
مواضيع طبية MeSH: Probiotics*/pharmacology , Probiotics*/administration & dosage , Rats, Inbred SHR* , Rats, Inbred WKY* , Colitis*/chemically induced , Colitis*/physiopathology , Colitis*/microbiology , Hemodynamics*/drug effects , Body Temperature*/drug effects, Animals ; Rats ; Male ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Heart Rate/drug effects ; Lactobacillus delbrueckii ; Obesity/physiopathology ; Obesity, Abdominal/physiopathology ; Obesity, Abdominal/chemically induced
مستخلص: We studied the dynamics of the main hemodynamic parameters in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats with visceral obesity and chemically induced colitis (CIC) against the background of probiotic therapy. Systolic BP, HR, and body temperature were recorded over 36 days using a wireless telemetry system. During 8 days (3 days before CIC induction and until the end of the experiment) the animals were intragastrically administered a probiotic based on Lactobacillus delbrueckii D5 strain. At baseline, systolic BP was significantly higher in the SHR group, while HR and body temperature did not differ in SHR and WKY rats. On day 8 after CIC induction, systolic BP, HR, and body temperature in SHR were significantly increased in comparison with the initial values. In the group of WKY rats, all indices at the end of the experiment remained at the initial levels. Probiotic therapy in SHR, in contrast to WKY rats, did not lead to normalization of body temperature and hemodynamic disorders resulting from CIC.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Wistar-Kyoto (WKY) rats; arterial pressure; hemodynamics; probiotics; spontaneously hypertensive rats (SHR)
تواريخ الأحداث: Date Created: 20240508 Date Completed: 20240517 Latest Revision: 20240517
رمز التحديث: 20240517
DOI: 10.1007/s10517-024-06064-5
PMID: 38717566
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-8221
DOI:10.1007/s10517-024-06064-5