دورية أكاديمية
Clinical and Microbial Determinants of Upper Respiratory Colonization with Streptococcus pneumoniae and Native Microbiota in People with HIV-1 and Control Adults.
| العنوان: | Clinical and Microbial Determinants of Upper Respiratory Colonization with Streptococcus pneumoniae and Native Microbiota in People with HIV-1 and Control Adults. |
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| المؤلفون: | Nicholson LK; Mucosal and Vaccine Research Program Colorado (MAVRC), USA.; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Denver VA Medical Center, Denver, CO, USA., Kofonow JM; Mucosal and Vaccine Research Program Colorado (MAVRC), USA.; University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Robertson CE; Mucosal and Vaccine Research Program Colorado (MAVRC), USA.; University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Wright T; Denver Health and Hospital Authority, Denver, CO, USA., Li Q; University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Gardner EM; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Denver Health and Hospital Authority, Denver, CO, USA., Frank DN; Mucosal and Vaccine Research Program Colorado (MAVRC), USA.; University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Janoff EN; Mucosal and Vaccine Research Program Colorado (MAVRC), USA.; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Denver VA Medical Center, Denver, CO, USA. |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2024 May 08. Date of Electronic Publication: 2024 May 08. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مستخلص: | Background: The substantial risk for respiratory and invasive infections with Streptococcus pneumoniae (Spn) among people with HIV-1 (PWH) begins with asymptomatic colonization. The frequency of Spn colonization among U.S. adults with and without HIV-1 infection is not well-characterized in the conjugate vaccine era. Methods: We determined Spn colonization frequency by culture and specific lytA gene QPCR and microbiota profile by 16S rRNA gene sequencing in nasopharyngeal (NP) and oropharyngeal (OP) DNA from 138 PWH and 93 control adults and associated clinical characteristics. Results: The frequencies of Spn colonization among PWH and controls did not differ (11.6% vs 8.6%, respectively; p=0.46) using combined results of culture and PCR, independent of vaccination or behavioral risks. PWH showed altered microbiota composition (i.e., beta-diversity. NP: p=0.0028, OP: p=0.0098), decreased alpha-diversity (NP: p=0.024, OP: p=0.0045), and differences in the relative abundance of multiple bacterial taxa. Spn colonization was associated with altered beta-diversity in the NP (p=0.011), but not OP (p=0.21). Conclusions: Despite widespread conjugate vaccine and antiretroviral use, frequencies of Spn colonization among PWH and controls are currently consistent with those reported in the pre-conjugate era. The persistently increased risk of pneumococcal disease despite ART may relate to behavioral and immunologic variables other than colonization. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: HIV-1; PWH; colonization; human microbiome; pneumococcus |
| تواريخ الأحداث: | Date Created: 20240508 Latest Revision: 20240508 |
| رمز التحديث: | 20240509 |
| DOI: | 10.1093/infdis/jiae247 |
| PMID: | 38718217 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6613 |
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| DOI: | 10.1093/infdis/jiae247 |