دورية أكاديمية
Assessing the impact of antiviral drugs commonly utilized during the COVID-19 pandemic on the embryonic development of Xenopus laevis.
| العنوان: | Assessing the impact of antiviral drugs commonly utilized during the COVID-19 pandemic on the embryonic development of Xenopus laevis. |
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| المؤلفون: | Laçin C; Laboratory of Environmental Toxicology, Department of Biology, Faculty of Arts and Science, Inonu University, 44280 Malatya, Turkey., Turhan DO; Laboratory of Environmental Toxicology, Department of Biology, Faculty of Arts and Science, Inonu University, 44280 Malatya, Turkey., Güngördü A; Laboratory of Environmental Toxicology, Department of Biology, Faculty of Arts and Science, Inonu University, 44280 Malatya, Turkey. Electronic address: abbas.gungordu@inonu.edu.tr. |
| المصدر: | Journal of hazardous materials [J Hazard Mater] 2024 Jul 05; Vol. 472, pp. 134462. Date of Electronic Publication: 2024 Apr 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, |
| مواضيع طبية MeSH: | Antiviral Agents*/toxicity , Xenopus laevis* , Oseltamivir*/toxicity , Embryonic Development*/drug effects , Amides*/toxicity , Embryo, Nonmammalian*/drug effects, Animals ; Pyrazines/toxicity ; COVID-19 ; COVID-19 Drug Treatment ; SARS-CoV-2/drug effects ; Larva/drug effects ; Teratogens/toxicity ; Carboxylesterase/metabolism |
| مستخلص: | The antiviral drugs favipiravir and oseltamivir are widely used to treat viral infections, including coronavirus 2019 (COVID-19), and their levels are expected to increase in the aquatic environment. In this study, the potential toxic and teratogenic effects of these drugs were evaluated using the frog embryo teratogenesis assay Xenopus (FETAX). In addition, glutathione S-transferase (GST), glutathione reductase (GR), catalase, carboxylesterase (CaE), and acetylcholinesterase (AChE) enzyme activities and malondialdehyde levels were measured as biochemical markers in embryos and tadpoles for comparative assessment of the sublethal effects of the test compounds. Prior to embryo exposure, drug concentrations in the exposure medium were measured with high-performance liquid chromatography. The 96-h median lethal concentration (LC Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Abbas Gungordu reports financial support was provided by Inonu University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antiviral drugs; Biomarkers COVID-19; Toxicity; Xenopus laevis |
| المشرفين على المادة: | 0 (Antiviral Agents) 20O93L6F9H (Oseltamivir) 0 (Amides) EW5GL2X7E0 (favipiravir) 0 (Pyrazines) 0 (Teratogens) EC 3.1.1.1 (Carboxylesterase) |
| تواريخ الأحداث: | Date Created: 20240508 Date Completed: 20240529 Latest Revision: 20240529 |
| رمز التحديث: | 20240529 |
| DOI: | 10.1016/j.jhazmat.2024.134462 |
| PMID: | 38718506 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3336 |
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| DOI: | 10.1016/j.jhazmat.2024.134462 |