دورية أكاديمية
Iodine Metabolism in Urine and Breast Milk among Lactating Women with Adequate Iodine.
| العنوان: | Iodine Metabolism in Urine and Breast Milk among Lactating Women with Adequate Iodine. |
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| المؤلفون: | Li S; Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China., Wang C; Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China., Cheng Y; Department of General Surgery, Gaoqing County People's Hospital, Gaoqing, China., Li J; Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China., Zhang H; Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China., Jin Q; Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China., Meng Q; Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China., Wu W; Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China., Wang T; Department of Obstetrics, Yuncheng County People's Hospital, Yuncheng, China., Liu D; Department of Clinical Laboratory, Yuncheng County People's Hospital, Yuncheng, China., Meng X; Department of Clinical Laboratory, Yuncheng County People's Hospital, Yuncheng, China., Guo W; Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. Electronic address: guowenxing@tmu.edu.cn., Zhang W; Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China; Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China. |
| المصدر: | The Journal of nutrition [J Nutr] 2024 Jul; Vol. 154 (7), pp. 2006-2013. Date of Electronic Publication: 2024 May 06. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0404243 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-6100 (Electronic) Linking ISSN: 00223166 NLM ISO Abbreviation: J Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York, NY] : Elsevier Original Publication: 1928-1933 : Springfield, Ill. : C. C. Thomas |
| مواضيع طبية MeSH: | Iodine*/urine , Iodine*/metabolism , Lactation*/metabolism , Milk, Human*/chemistry , Milk, Human*/metabolism, Adult ; Female ; Humans ; China ; Cohort Studies |
| مستخلص: | Background: In lactating women, iodine metabolism is regulated and maintained by the kidneys and mammary glands. Limited research exists on how iodine absorbed by lactating women is distributed between the kidneys and breasts. Objectives: This study aimed to accurately evaluate the total iodine intake (TII), urinary iodine excretion (UIE), and breast milk iodine excretion (BMIE) in lactating women and explore the relationship between TII and total iodine excretion (TIE). Methods: A 7-d iodine metabolism study was conducted on 41 lactating women with a mean age of 30 y in Yuncheng and Gaoqing, China, from December 2021 to August 2023. TII and TIE were calculated by measuring the iodine content in food, water, 24-h urine, feces, and breast milk. The urinary iodine excretion rate (UIER), breast milk iodine excretion rate (BMIER), and partitioning of iodine excretion between urine and breast milk were determined. Results: Iodine metabolism studies were performed for 285 d. The median TII and TIE values were 255 and 263 μg/d, respectively. With an increase in TII, UIER, and BMIER, the UIE and BMIE to TII ratio exhibited a downward trend. The median UIER, BMIER, and proportion of iodine excreted in urine and breast milk were 51.5%, 38.5%, 52%, and 37%, respectively. When the TII was <120 μg/d, the BMIER decreased with the increase of the TII (β: -0.90; 95% confidence interval: -1.08, -0.72). Conclusions: When maternal iodine intake is low, the proportion in breast milk increases, ensuring sufficient iodine nutrition for infants. In addition, the UIE of lactating women with adequate iodine concentrations is higher than their BMIE. This study was registered at clinicaltrials.gov as NCT04492657. (Copyright © 2024 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: breast milk iodine excretion; iodine balance; iodine intake; lactating women; urinary iodine excretion |
| سلسلة جزيئية: | ClinicalTrials.gov NCT04492657 |
| المشرفين على المادة: | 9679TC07X4 (Iodine) |
| تواريخ الأحداث: | Date Created: 20240508 Date Completed: 20240705 Latest Revision: 20240709 |
| رمز التحديث: | 20240710 |
| DOI: | 10.1016/j.tjnut.2024.04.041 |
| PMID: | 38718924 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1541-6100 |
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| DOI: | 10.1016/j.tjnut.2024.04.041 |