دورية أكاديمية
Mito-Tempo alleviates ox-LDL-provoked foam cell formation by regulating Nrf2/NLRP3 signaling.
| العنوان: | Mito-Tempo alleviates ox-LDL-provoked foam cell formation by regulating Nrf2/NLRP3 signaling. |
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| المؤلفون: | Huang Z; Department of Neurosurgery, the Second Affiliated Hospital of Soochow University, Suzhou, China., Zhou Z; Shanghai Key Laboratory for Molecular Imaging, Collaborative Scientific Research Center, Shanghai University of Medicine & Health Science, Shanghai, China.; Department of Pharmacology, School of Pharmacy, Shanghai University of Medicine & Health Science, Shanghai, China., Ma Y; Department of Geriatrics, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Hu YM; Department of Geriatrics, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. |
| المصدر: | Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2024 Jun 21; Vol. 88 (7), pp. 759-767. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9205717 Publication Model: Print Cited Medium: Internet ISSN: 1347-6947 (Electronic) Linking ISSN: 09168451 NLM ISO Abbreviation: Biosci Biotechnol Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Oxford : Oxford University Press Original Publication: Tokyo, Japan : Japan Society for Bioscience, Biotechnology, and Agrochemistry, c1992- |
| مواضيع طبية MeSH: | NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Lipoproteins, LDL*/metabolism , NF-E2-Related Factor 2*/metabolism , Foam Cells*/drug effects , Foam Cells*/metabolism , Signal Transduction*/drug effects, Mice ; Animals ; Inflammasomes/metabolism ; Inflammasomes/drug effects ; Pyroptosis/drug effects ; Humans ; RAW 264.7 Cells ; Cyclic N-Oxides/pharmacology ; CD36 Antigens/metabolism ; Organophosphorus Compounds ; Piperidines |
| مستخلص: | Our previous studies have demonstrated that Mito-Tempol (also known as 4-hydroxy-Tempo), a mitochondrial reactive oxygen species scavenger, alleviates oxidized low-density lipoprotein (ox-LDL)-triggered foam cell formation. Given the effect of oxidative stress on activating the NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome, which promotes foam cell formation, we aimed to explore whether Mito-Tempo inhibits ox-LDL-triggered foam cell formation by regulating NLRP3 inflammasome. The results revealed that Mito-Tempo re-activated Nrf2 and alleviated macrophage foam cell formation induced by ox-LDL, whereas the effects were reversed by ML385 (a specific Nrf2 inhibitor). Mito-Tempo restored the expression and nuclear translocation of Nrf2 by decreasing ox-LDL-induced ubiquitination. Furthermore, Mito-Tempo suppressed ox-LDL-triggered NLRP3 inflammasome activation and subsequent pyroptosis, whereas the changes were blocked by ML385. Mito-Tempo decreased lipoprotein uptake by inhibiting CD36 expression and suppressed foam cell formation by regulating the NLRP3 inflammasome. Taken together, Mito-Tempo exhibits potent anti-atherosclerotic effects by regulating Nrf2/NLRP3 signaling. (© The Author(s) 2024. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.) |
| معلومات مُعتمدة: | 82000406 National Natural Science Foundation of China |
| فهرسة مساهمة: | Keywords: Mito-Tempo; Nrf2; atherosclerosis; foam cell; macrophage |
| المشرفين على المادة: | 0 (NLR Family, Pyrin Domain-Containing 3 Protein) 0 (Lipoproteins, LDL) 0 (NF-E2-Related Factor 2) 0 (oxidized low density lipoprotein) 0 (Inflammasomes) 0 (Nfe2l2 protein, mouse) 0 (Nlrp3 protein, mouse) 0 (Cyclic N-Oxides) 0 (CD36 Antigens) 0 (MitoTEMPO) 0 (Organophosphorus Compounds) 0 (Piperidines) |
| تواريخ الأحداث: | Date Created: 20240508 Date Completed: 20240621 Latest Revision: 20240630 |
| رمز التحديث: | 20240630 |
| DOI: | 10.1093/bbb/zbae058 |
| PMID: | 38719485 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1347-6947 |
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| DOI: | 10.1093/bbb/zbae058 |