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Effects of a combined exercise and dietary intervention on body composition, physical functioning and fatigue in patients with ovarian cancer: results of the PADOVA trial.

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العنوان: Effects of a combined exercise and dietary intervention on body composition, physical functioning and fatigue in patients with ovarian cancer: results of the PADOVA trial.
المؤلفون: Kenkhuis MF; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands., Stelten S; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands., Hartman YA; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands., Brouwer CG; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands., Ten Tusscher MR; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands., van Lonkhuijzen LR; Obstetrics and Gynaecology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Kenter GG; Obstetrics and Gynaecology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Obstetrics and Gynaecology, Cancer Center Amsterdam, Center for Gynaecologic Oncology Amsterdam (CGOA), Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Gynaecology, Center for Gynaecologic Oncology Amsterdam (CGOA), The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands., van Driel WJ; Gynaecology, Center for Gynaecologic Oncology Amsterdam (CGOA), The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands., Winkels RM; Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands., Bekkers RL; Department of Obstetrics and Gynaecology, Grow school for oncology and reproduction, Maastricht University, Maastricht, The Netherlands.; Department of Gynecology, Catharina Hospital, Eindhoven, The Netherlands.; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands., Ottevanger NP; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands., Hoedjes M; CoRPS-Center of Research on Psychological and Somatic Disorders, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands., Buffart LM; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands. laurien.buffart@radboudumc.nl.
المصدر: British journal of cancer [Br J Cancer] 2024 Jul; Vol. 131 (1), pp. 101-109. Date of Electronic Publication: 2024 May 08.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
أسماء مطبوعة: Publication: 2002- : London : Nature Publishing Group on behalf of Cancer Research UK
Original Publication: London, Lewis.
مواضيع طبية MeSH: Fatigue*/etiology , Ovarian Neoplasms*/diet therapy , Ovarian Neoplasms*/complications , Body Composition*, Humans ; Female ; Middle Aged ; Exercise/physiology ; Aged ; Exercise Therapy/methods ; Adult
مستخلص: Background: Guidelines recommend to include exercise and dietary advice in standard care for patients with cancer, based on evidence primarily derived from patients with breast cancer. Its applicability to patients with ovarian cancer is uncertain due to differences in patient characteristics and treatments. The PADOVA trial examined the effectiveness of a combined exercise and dietary intervention on fat-free mass (FFM), physical functioning, and fatigue.
Methods: In total, 81 patients with ovarian cancer were randomised to the exercise and dietary intervention (n = 40) or control (n = 41) group. Measurements were performed before chemotherapy, after chemotherapy, and 12 weeks later. FFM was assessed by bioelectrical impedance analysis, and physical functioning and fatigue were assessed using questionnaires. Intervention effects were assessed on an intention-to-treat basis using linear mixed models.
Results: FFM and physical functioning increased, and fatigue decreased significantly over time in both groups. No significant difference between the groups were found for FFM (β = -0.5 kg; 95% CI = -3.2; 2.1), physical functioning (β = 1.4; 95% CI = -5.4; 8.3) and fatigue (β = 0.7; 95% CI = -1.5; 2.8).
Conclusions: During treatment, both groups improved in FFM, physical functioning, and fatigue. The intervention group, however, did not demonstrate additional benefits compared to the control group. This highlights the need for caution when extrapolating findings from different cancer populations to patients with ovarian cancer.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
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معلومات مُعتمدة: 2015-7950 KWF Kankerbestrijding (Dutch Cancer Society)
تواريخ الأحداث: Date Created: 20240508 Date Completed: 20240708 Latest Revision: 20240831
رمز التحديث: 20240831
مُعرف محوري في PubMed: PMC11231132
DOI: 10.1038/s41416-024-02694-8
PMID: 38720046
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-1827
DOI:10.1038/s41416-024-02694-8