دورية أكاديمية
Higher abundance of 2-dehydro-d-gluconate in the plasma of sub-fertile or infertile Bos taurus heifers.
| العنوان: | Higher abundance of 2-dehydro-d-gluconate in the plasma of sub-fertile or infertile Bos taurus heifers. |
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| المؤلفون: | Marrella M; School of Animal Sciences, Virginia Polytechnique Institute and State University, Blacksburg, VA 24061, USA., Moorey SED; Department of Animal Science, University of Tennessee, Knoxville, TN 37996, USA., Campagna SR; Department of Chemistry, University of Tennessee, Knoxville, TN 37919, USA., Sarumi Q; Department of Chemistry, University of Tennessee, Knoxville, TN 37919, USA., Biase FH; School of Animal Sciences, Virginia Polytechnique Institute and State University, Blacksburg, VA 24061, USA. |
| المصدر: | Journal of animal science [J Anim Sci] 2024 Jan 03; Vol. 102. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Animal Science Country of Publication: United States NLM ID: 8003002 Publication Model: Print Cited Medium: Internet ISSN: 1525-3163 (Electronic) Linking ISSN: 00218812 NLM ISO Abbreviation: J Anim Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Champaign, IL : American Society of Animal Science |
| مواضيع طبية MeSH: | Fertility*, Animals ; Cattle/blood ; Female ; Gluconates ; Pregnancy ; Insemination, Artificial/veterinary ; Metabolome ; Cattle Diseases/blood |
| مستخلص: | Infertility or subfertility impacts approximately 5% and 15% of dairy and beef heifers (Bos taurus), respectively. Heifers that do not produce a calf within an optimum window of time have a significant negative impact on the profitability and sustainability of the cattle industry. Selection of heifers based on their fertility potential remains a challenge yet to be resolved. Here, we tested the hypothesis that heifers of different fertility potential have differing metabolome signatures in their plasma. We obtained blood from Bos taurus heifers at their first artificial insemination and processed the samples to separate the plasma. The heifers were classified based on their reproductive outcome as fertile (pregnant and delivered a calf after their first artificial insemination (AI)) or sub-fertile (Angus heifers: no pregnancy after two AI and exposure to a bull; Holstein heifers: no pregnancy by the third AI). We tested the relative abundance of 140 metabolites obtained from 22 heifers (Angus fertile n = 5, Angus sub-fertile n = 7, Holstein fertile N = 5, Holstein sub-fertile N = 5). The metabolite 2-Dehydro-D-gluconate (C6H10O7) was significantly more abundant in the plasma of sub-fertile heifers in both breeds (1.4-fold, false discovery rate < 0.1). In the context that a small proportion of circulating metabolites in the plasma were quantified in this study, the results show that the metabolomic profile in the blood stream may be associated with heifer fertility potential. (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
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| فهرسة مساهمة: | Keywords: fertility; metabolome; pregnancy Local Abstract: [plain-language-summary] During the development of heifers for cow replacement, producers must invest substantial resources in each animal for over 15 mo. While the use of resources is equivalent across heifers being developed on a farm, a substantial proportion of the animals will not produce a calf (approximately 5% and approximately 15% of dairy and beef heifers, respectively). In this study, we identified one metabolite with higher abundance in the plasma of dairy and beef heifers with low chances of producing a calf by 25 mo of age. |
| المشرفين على المادة: | 0 (Gluconates) |
| تواريخ الأحداث: | Date Created: 20240509 Date Completed: 20240715 Latest Revision: 20240717 |
| رمز التحديث: | 20240717 |
| مُعرف محوري في PubMed: | PMC11247527 |
| DOI: | 10.1093/jas/skae126 |
| PMID: | 38720650 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1525-3163 |
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| DOI: | 10.1093/jas/skae126 |