دورية أكاديمية
أعرض في EDS

Different contractility modes control cell escape from multicellular spheroids and tumor explants.

التفاصيل البيبلوغرافية
العنوان: Different contractility modes control cell escape from multicellular spheroids and tumor explants.
المؤلفون: Blauth E; Peter Debye Institute for Soft Matter Physics, Leipzig University, Linnéstraße 5, 04103 Leipzig, Germany., Grosser S; Institute for Bioengineering of Catalonia, The Barcelona Institute for Science and Technology, Barcelona 08028, Spain., Sauer F; Peter Debye Institute for Soft Matter Physics, Leipzig University, Linnéstraße 5, 04103 Leipzig, Germany., Merkel M; Peter Debye Institute for Soft Matter Physics, Leipzig University, Linnéstraße 5, 04103 Leipzig, Germany., Kubitschke H; Peter Debye Institute for Soft Matter Physics, Leipzig University, Linnéstraße 5, 04103 Leipzig, Germany., Warmt E; Peter Debye Institute for Soft Matter Physics, Leipzig University, Linnéstraße 5, 04103 Leipzig, Germany., Morawetz EW; Peter Debye Institute for Soft Matter Physics, Leipzig University, Linnéstraße 5, 04103 Leipzig, Germany., Friedrich P; Peter Debye Institute for Soft Matter Physics, Leipzig University, Linnéstraße 5, 04103 Leipzig, Germany., Wolf B; Department of Gynecology, Leipzig University Hospital, 04103 Leipzig, Germany., Briest S; Department of Gynecology, Leipzig University Hospital, 04103 Leipzig, Germany., Hiller GGR; Division of Breast, Urogenital and Perinatal Pathology, University Hospital Leipzig, Leipzig, Germany., Horn LC; Division of Breast, Urogenital and Perinatal Pathology, University Hospital Leipzig, Leipzig, Germany., Aktas B; Department of Gynecology, Leipzig University Hospital, 04103 Leipzig, Germany., Käs JA; Peter Debye Institute for Soft Matter Physics, Leipzig University, Linnéstraße 5, 04103 Leipzig, Germany.
المصدر: APL bioengineering [APL Bioeng] 2024 May 07; Vol. 8 (2), pp. 026110. Date of Electronic Publication: 2024 May 07 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: AIP Publishing Country of Publication: United States NLM ID: 101726398 Publication Model: eCollection Cited Medium: Internet ISSN: 2473-2877 (Electronic) Linking ISSN: 24732877 NLM ISO Abbreviation: APL Bioeng Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Melville, NY : AIP Publishing, [2017]-
مستخلص: Cells can adapt their active contractile properties to switch between dynamical migratory states and static homeostasis. Collective tissue surface tension, generated among others by the cortical contractility of single cells, can keep cell clusters compact, while a more bipolar, anisotropic contractility is predominantly used by mesenchymal cells to pull themselves into the extracellular matrix (ECM). Here, we investigate how these two contractility modes relate to cancer cell escape into the ECM. We compare multicellular spheroids from a panel of breast cancer cell lines with primary tumor explants from breast and cervical cancer patients by measuring matrix contraction and cellular spreading into ECM mimicking collagen matrices. Our results in spheroids suggest that tumor aggressiveness is associated with elevated contractile traction and reduced active tissue surface tension, allowing cancer cell escape. We show that it is not a binary switch but rather the interplay between these two contractility modes that is essential during this process. We provide further evidence in patient-derived tumor explants that these two contractility modes impact cancer cells' ability to leave cell clusters within a primary tumor. Our results indicate that cellular contractility is an essential factor during the formation of metastases and thus may be suitable as a prognostic criterion for the assessment of tumor aggressiveness.
Competing Interests: The authors have no conflicts to disclose.
(© 2024 Author(s).)
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تواريخ الأحداث: Date Created: 20240509 Latest Revision: 20240510
رمز التحديث: 20240510
مُعرف محوري في PubMed: PMC11078555
DOI: 10.1063/5.0188186
PMID: 38721268
قاعدة البيانات: MEDLINE
الوصف
تدمد:2473-2877
DOI:10.1063/5.0188186