دورية أكاديمية
أعرض في EDS

Anti-inflammatory, anti-oxidant and anti-ulcer activities of aqueous lyophilizate of Markhamia lutea (Bignoniaceae).

التفاصيل البيبلوغرافية
العنوان: Anti-inflammatory, anti-oxidant and anti-ulcer activities of aqueous lyophilizate of Markhamia lutea (Bignoniaceae).
المؤلفون: Chrétien NM; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Zenab Linda FN; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Brice Junior NN; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Marcelle Olga FY; Laboratory of Biology and Physiology of Animal Organisms, Department of Biology of Animal Organisms, Faculty of Science, The University of Douala Cameroon, Douala, Cameroon., Vanessa Mba MM; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Stephanie Flore DN; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Yacine Karelle MK; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Elvira NA; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Marius M; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Gilbert A; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon.
المصدر: Journal of complementary & integrative medicine [J Complement Integr Med] 2024 May 10; Vol. 21 (2), pp. 248-257. Date of Electronic Publication: 2024 May 10 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 101313855 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-3840 (Electronic) Linking ISSN: 15533840 NLM ISO Abbreviation: J Complement Integr Med Subsets: MEDLINE
أسماء مطبوعة: Publication: <2012-> : Berlin : Walter de Gruyter
Original Publication: Berkeley, Calif. : Berkeley Electronic Press, 2004-
مواضيع طبية MeSH: Antioxidants*/pharmacology , Anti-Inflammatory Agents*/pharmacology , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Anti-Ulcer Agents*/pharmacology , Stomach Ulcer*/drug therapy , Stomach Ulcer*/chemically induced , Freeze Drying*, Animals ; Male ; Rats, Wistar ; Rats ; Mice
مستخلص: Objectives: This work was carried out with a view to determining the antioxidant, anti-inflammatory and anti-ulcer properties of the aqueous lyophilized extract of Markhamia lutea .
Methods: In vitro proteinases inhibition, albumin denaturation, hemolysis of red blood cells by heat, inhibition of the proton pump H + /K + ATPase, FRAP (Ferric reducing antioxidant power) and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays were performed. In vivo , cold water immersion-induced ulceration and methylene blue-induced ulceration was used to determine the anti-ulcer properties of the lyophilizate (100, 200 and 300 mg/kg).
Results: In vitro , the lyophilizate (400 μg/mL) significantly inhibited protein denaturation (66.65 %), hemolysis of red blood cells (56.54 %), proteinase activity (69.22 %); then the IC 50 was 26.31 μg/mL on proton pump activity. It has also developed a strong ferric reducing antioxidant power (EC 50 =52.96 mmol FeSO 4 /g) as well as free radicals scavenging activity (EC 50 =22.38 μg/mL). In vivo , the aqueous lyophilizate (200 and 300 mg/kg) protected the gastric mucosa (70.68 and 79.00 % protection respectively) and reduced (p<0.05) acetylcholine, calcium and corticosterone concentrations. A decrease in malondialdehyde level, an increased glutathione level and an increased in catalase and SOD activities were recorded. In the methylene blue test, it significantly increased gastric fluid pH, while reducing gastric volume and improving hematological parameters in ulcer animals. In addition, the histological sections show that the aqueous lyophilizate of M. lutea protected the gastric mucosa from the deleterious effects of stress.
Conclusions: The aqueous lyophilizate of M. lutea has anti-ulcer properties thanks to its anti-inflammatory, antioxidant and anti-secretory properties.
(© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
References: Ruixue, L, Wenyuan, W, Yaping, M, Hong, C. Analysis of risk factors for ulcer recurrence and upper gastrointestinal bleeding in children with peptic ulcer treated with Helicobacter pylori eradication therapy. Transl Pediatr 2023;12:618–30. https://doi.org/10.21037/tp-23-155 . (PMID: 10.21037/tp-23-155)
Dong-Qin, Z, Hua, X, Hai-Ji, S. Nervous mechanisms of restraint water-immersion stress-induced gastric mucosal lesion. World J Gastroenterol 2020;26:2533–49. https://doi.org/10.3748/wjg.v26.i20.2533 . (PMID: 10.3748/wjg.v26.i20.2533)
Himani, G, Bhandari, U. Peptic ulcer and role of a polyherbal formulation in pathogenesis of ulcer in Wistar rats. J Sci Tech Res 2023;50:41894–900.
Sufiyan, SA, Najmi, AK, Kaundal, M, Mohd, A. Gastroprotective effect of thymoquinone on water immersion restraint stress induced ulceration in rats. Drug Res 2017;67:2194–9379.
Robles, TF, Carroll, JE. Restorative biological processes and health. Soc Pers Psychol Compass 2011;5:518–37. https://doi.org/10.1111/j.1751-9004.2011.00368.x . (PMID: 10.1111/j.1751-9004.2011.00368.x)
Sahoo, N, Mingxue, G, Xiaoli, Z, Neel, R, Yang, J, Bekier, et al.. Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle. Dev Cell 2017;41:262–73. https://doi.org/10.1016/j.devcel.2017.04.003 . (PMID: 10.1016/j.devcel.2017.04.003)
Câmara, R, Griessenauer, JR. Anatomy of the vagus nerve. Nerves Nerve Inj 2015;27:385–97. https://doi.org/10.1016/b978-0-12-410390-0.00028-7 . (PMID: 10.1016/b978-0-12-410390-0.00028-7)
Mejia, A, Kraft, WK. Acid peptic diseases: pharmacological approach to treatment. Expert Rev Clin Pharmacol 2009;2:295–314. https://doi.org/10.1586/ecp.09.8 . (PMID: 10.1586/ecp.09.8)
Hidekazu, S, Toshihiro, N, Hitoshi, T, Sachiko, M, Toshifumi, H. Roles of oxidative stress in stomach disorders. J Clin Biochem Nutr 2012;50:35–9. https://doi.org/10.3164/jcbn.11-115SR . (PMID: 10.3164/jcbn.11-115SR)
Shah, DI, Dev, D, Santani, SS, Goswami, A. A novel use of methylene blue as a pharmacological tool. J Pharmacol Toxicol Methods 2006;54:273–7. https://doi.org/10.1016/j.vascn.2005.12.003 . (PMID: 10.1016/j.vascn.2005.12.003)
Pfaffendroff, M, Brunning, TA, Batink, HD, Van Zwieten, PA. The interaction between methylene blue and the cholinergic system. Br J Pharmacol 1997;122:95–8. https://doi.org/10.1038/sj.bjp.0701355 . (PMID: 10.1038/sj.bjp.0701355)
Coulibaly, L. Etude de la dispensation des antiulcereux dans les officines privées de nioro et de bamako. Thèse de doctorat. Université des sciences, des techniques et des technologies de bamako; 2020:88 p.
Castillo, L, Diaz, M, Gonzalez-Coloma, A, Gonzalez, A, Alonso-Paz, E, Bassagoda, MJ, et al.. Clytostoma callistegioides (Bignoniaceae) wax extract with activity on aphid settling. Phytochemical 2010;71:2052–7. https://doi.org/10.1016/j.phytochem.2010.08.016 . (PMID: 10.1016/j.phytochem.2010.08.016)
Fischer, E, Theisen, I, Lohmann, LG, Kadereit, JK. Bignoniaceae, flowering plants dicotyledons. The families and genera of vascular plants , Kubitzki, K, editor. Berlin: Springer Berlin Heidelberg; 2004, 7:9–13 pp.
Tantangmo, F, Lenta, BN, Boyom, FF, Ngouela, S, Kaiser, M, Tsamo, E, et al.. Antiprotozoal activities of some constituents of Markhamia tomentosa (Bignoniaceae). Ann Trop Med Parasitol 2010;104:391–8. https://doi.org/10.1179/136485910x12743554760180 . (PMID: 10.1179/136485910x12743554760180)
Lacroix, D, Prado, S, Deville, A, Krief, S, Dumontet, V, Kasenene, J, et al.. Hydroperoxy-cycloartane triterpenoids from the leaves of Markhamia lutea, a plant ingested by wild chimpanzees. Phytochemistry 2009;70:1239–45. https://doi.org/10.1016/j.phytochem.2009.06.020 . (PMID: 10.1016/j.phytochem.2009.06.020)
Shaimaa, A, Sherweit, E, Nahla, A, Abdel, NS. Phytochemicals of Markhamia species (Bignoniaceae) and their therapeutic value. J Med Plants Res 2015;6:124–42.
Joshi, KC, Singh, P, Sharma, MC. Quinones and other constituents of Markhamia platycalyx and bignonia unguiscati. J Nat Prod 1985;48:145. https://doi.org/10.1021/np50037a031 . (PMID: 10.1021/np50037a031)
Mahmoud, BK, Hamed, AN, Samy, MN, Mostafa, EM, Wanas, AS, Radwan, MM, et al.. Phytochemical composition and antimicrobial properties of Markhamia platycalyx (Baker) Sprague leaf. Trop J Pharmaceut Res 2019;18:2623–31.
Fagni, NZL, Mbiantcha, M, Djuichou Nguemnang, SF, Matah Marthe, VM, Yousseu, NW, Madjo Kouam, YK, et al.. Anti-helicobacter pylori, anti-inflammatory, and antioxidant activities of trunk bark of Alstonia boonei (Apocynaceae). BioMed Res Int 2022;2022:9022135. https://doi.org/10.1155/2022/9022135 . (PMID: 10.1155/2022/9022135)
Sakat, S, Juvekar, ARG. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn I. J Pharm Pharmaceut Sci 2010;2:146–55.
William, NY, Billong, MJR, Atsamo, AD, Tsafack, EG, Djuichou Nguemnang, SF, Fagni Njoya, ZL, et al.. In vitro and in vivo anti-inflammatory properties of the hydroethanolic extract of the roots of vernonia guineensis (Asteraceae). Int J Inflamm 2023;2023:7915367. https://doi.org/10.1155/2023/7915367 . (PMID: 10.1155/2023/7915367)
Mensor, LL, Menezes, FS, Leitao, GG, Reis, AS, Dos Santos, TC, Coube, CS, et al.. Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytother Res 2001;15:127–30. https://doi.org/10.1002/ptr.687 . (PMID: 10.1002/ptr.687)
Yassa, N, Razavi, HB, Hadjiakhoondi, A. Free radical scavenging and lipid peroxidation activity of the Shahani black grape. Pakistan J Biol Sci 2008;11:2513–16. https://doi.org/10.3923/pjbs.2008.2513.2516 . (PMID: 10.3923/pjbs.2008.2513.2516)
Reyes-Chilpa, R, Baggio, CH, Alavez, D, Estrada-Muniza, E, Kauffmanc, FC, Sanchezc, RI, et al.. Inhibition of gastric H+, K+-ATPase by flavonoids, coumarins and xanthones isolated from Mexican medicinal plants. J Ethnopharmacol 2006;105:167–72. https://doi.org/10.1016/j.jep.2005.10.014 . (PMID: 10.1016/j.jep.2005.10.014)
Dimo, T, Tsala, DE, Dzeufiet, DPD, Penlap, BV, Njifutie, N. Effects of alafia multiflora stapf on lipid peroxidation and antioxidant enzyme status in carbon tetrachloride-treated rats. Pharmacologyonline 2006;2:76–89.
Fermor, B, Christensen, SE, Youn, I, Cernanec, JM, Davies, CM, Weinberg, JB. Oxygen, nitric oxide and articular cartilage. Eur Cell Mater 2007;13:56–65. https://doi.org/10.22203/ecm.v013a06 . (PMID: 10.22203/ecm.v013a06)
Kebieche, M. Activité biochimique des extraits flavonoidiques de la plante Ranunculus repens L: Effet sur le diabète expérimental et l’hépatotoxicité induite par l’Epirubicine. Biochimie, These de Doctorat. Université Mentouri Constantine 2009:143 p.
Okoli, CO, Akah, PA, Onuoha, NJ, Okoye, TC, Nwoye, AC, Nworu, CS. Acanthus montanus: an experimental evaluation of the antimicrobial, anti-inflammatory and immunological properties of a traditional remedy for furuncles. BMC Compl Alternative Med 2008;6:27. https://doi.org/10.1186/1472-6882-8-27 . (PMID: 10.1186/1472-6882-8-27)
Leelaprakash, G, Mohan-Dass, S. In vitro anti-inflammatory activity of methanol extract of Enicostemma axillare. Int J Drug Dev Res 2011;3:189–96.
Ruiz-Ruiz, JC, Matus-Basto, AJ, Acereto-Escoffié, P, Rubí, M. Antioxidant and anti-inflammatory activities of phenolic compounds isolated from Melipona beecheii honey Segura-Campos. Food Agric Immunol 2017;28:1424–37. https://doi.org/10.1080/09540105.2017.1347148 . (PMID: 10.1080/09540105.2017.1347148)
Gunathilake, KDPP, Ranaweera, KKDS, Vasantha Rupasinghe, HP. In vitro anti-inflammatory properties of selected green leafy vegetables. Biomedicines 2018;6:107. https://doi.org/10.3390/biomedicines6040107 . (PMID: 10.3390/biomedicines6040107)
Umapathy, E, Ndebia, EJ, Meeme, A, Adam, B, Menziwa, P, Nkeh-Chungag, BN, et al.. An experimental evaluation of Albuca setosa aqueous extract on membrane stabilization, protein denaturation and white blood cell migration during acute inflammation. J Med Plants Res 2010;4:789–95.
Umamaheswari, M, Chatterjee, TK. In vitro antioxidant activities of the fractions of Coccinnia grandis L. leaf extract. Afr J Tradit, Complementary Altern Med 2008;5:61–73. https://doi.org/10.4314/ajtcam.v5i1.31258 . (PMID: 10.4314/ajtcam.v5i1.31258)
Saha, AK, Rahman, MR, Shahriar, M, Azad, NA, Das, S. Screening of six ayurvedic medicinal plant extracts for antioxidant and cytotoxic activity. J Pharmacogn Phytochem 2013;2:181–8.
El-Chaghaby, GA, Ahmad, AF, Ramis, ES. Evaluation of the antioxidant and antibacterial properties of various solvents extracts of Annona squamosa L. leaves. Arab J Chem 2014;7:227–33. https://doi.org/10.1016/j.arabjc.2011.06.019 . (PMID: 10.1016/j.arabjc.2011.06.019)
Yousseu, NW, Ateufack, G, Abdul, JS, Mbiantcha, M, Tchoumba, TLM, Matah Mba, MV, et al.. Extracts from the trunk bark of Distemonanthus benthamianus Baillon. (Caesalpiniaceae) developed antidiarrhoeal activities in rats and mice. Orient Pharm Exp Med 2019;19:421–33. https://doi.org/10.1007/s13596-019-00385-x . (PMID: 10.1007/s13596-019-00385-x)
Shan, L, Wu, D, Guibo, S, Funeng, G, Yongmei, S, Tand, J, et al.. Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival. Pharm Biol 2019;57:770–7. https://doi.org/10.1080/13880209.2019.1682620 . (PMID: 10.1080/13880209.2019.1682620)
Plummer, MP, Blaser, AR, Deane, AM. Stress ulceration: prevalence, pathology and association with adverse outcomes. Crit Care 2014;18:213. https://doi.org/10.1186/cc13780 . (PMID: 10.1186/cc13780)
Faezeh, T, Abbas, A, Sareh, K, Si, L, Nur’ain, B, Gokula, M. Ulcer prevention effect of 3,4,5-Tihydroxy-N0-[(2-Methyl-1H-Indol 3yl) Methylidene] benzohydrazide in HCl/ethanol-induced gastric mucosal damage in rats. Int J Med Sci 2017;14:17–26.
Furutani, K, Aihara, T, Nakamura, E, Tanaka, S, Ichikawa, A, Ohtsu, H, et al.. Crucial role of histamine for regulation of gastric acid secretion ascertained by histidine decarboxylase-knockout mice. J Pharmacol Exp Therapeut 2003;307:331–8. https://doi.org/10.1124/jpet.103.052019 . (PMID: 10.1124/jpet.103.052019)
Aihara, T, Nakamura, E, Amagase, K, Tomita, K, Fujishita, T, Furutani, K, et al.. Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future. Pharmacol Therapeut 2005;98:109–27. https://doi.org/10.1016/s0163-7258(03)00015-9 . (PMID: 10.1016/s0163-7258(03)00015-9)
Heloina de, SF, Leite, AJ, Barbosa-Filho, JM, Filgueiras de Athayde, FP, Célia de Oliveira, CM, Moura, MD, et al.. Gastric and duodenal antiulcer activity of alkaloids. Rev Mol 2008;13:3198–223.
El-Zaatari, M, Yana, Z, Tessier, A, Waghray, M, Lentz, S, Gumucio, D, et al.. Intracellular calcium-release and protein kinase C-activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology 2010;139:2061–71. https://doi.org/10.1053/j.gastro.2010.08.047 . (PMID: 10.1053/j.gastro.2010.08.047)
Sandu, C, Artunc, F, Grahammer, F, Rotte, A, Boini, KM, Friedrich, B, et al.. Role of the serum and glucocorticoid inducible kinase SGK1 in glucocorticoid stimulation of gastric acid secretion. Pflügers Archiv 2007;455:493–503. https://doi.org/10.1007/s00424-007-0305-4 . (PMID: 10.1007/s00424-007-0305-4)
Rizzi, PA. Les troubles digestifs liés au stress: considérations psychosomatiques et prise en charge à l’offcine. Thèse de doctorat. Université de LORRAINE; 2016:139 p.
Kudryavtsev, KV, Markevich, AO, Oleksandr, VV, Tetyana, MF, Tetyana, VB, Lyudmyla, IO, et al.. Pharmacological correction of stress-induced gastric ulceration by novel small-molecule agents with antioxidant profile. Sci World J 2014;2014:6.
Fornai, M, Colucci, R, Antonioli, L, Awwad, O, Ugolini, C, Tuccori, M, et al.. Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: characterization of molecular mechanisms. Pharmacol Res 2011;63:59–67. https://doi.org/10.1016/j.phrs.2010.10.013 . (PMID: 10.1016/j.phrs.2010.10.013)
Matah, MMV, Ateufack, G, Mbiantcha, M, Atsamo, AD, Adjouzem, FC, Djuichou, SF, et al.. Methanolic extract of distemonanthus benthamianus (caesalpiniaceae) stem bark suppresses ethanol/indomethacin induced chronic gastric injury in rats. Gastroenterol Res Pract 2020;2020:14.
Boulaiche, H, Boulchefar, L, Bouldjadj, S. Effet antioxydant et néphroprotecteur du thé vert (Camellia sinensis) (Revue systématique). Mémoire de Master, Université Mohammed Seddik Ben Yahia Jijel. Algérie 2020;2020:71.
Townsend, DM, Tew, KD, Tapiero, H. The importance of glutathione in human disease. Biomed Pharmacother 2003;57:144–55. https://doi.org/10.1016/s0753-3322(03)00043-x . (PMID: 10.1016/s0753-3322(03)00043-x)
Ateufack, G, Matah, M, Tchoumbou, H, Yousseu, NW, Dongmo, F, Adjouzem, C, et al.. Preventive and curative properties of aqueous and methanolic extracts of Distemonanthus benthamianus stem barks on acute and chronic gastric ulcers in male rats. Eur J Pharm Med Res 2018;5:402–13.
Rashedunnabi, A, In-Shik, K, Dongchoon, A, Hyun-Jin, T, Hyeon-Hwa, N, Byung-Kil, C, et al.. Anti-inflammatory and gastroprotective roles of rabdosia inflexa through downregulation of pro-inflammatory cytokines and MAPK/NF-κB signaling pathways. Int J Mol Sci 2018;19:584. https://doi.org/10.3390/ijms19020584 . (PMID: 10.3390/ijms19020584)
Ekambaram, S, Senthami, S, Venkataraman, S. Evaluation of antiarthritic activity of Strychnos potarum linn seeds in Freund’s adjuvant-induced arthritic rat model. BMC Compl Alternative Med 2010;10:1–9. https://doi.org/10.1186/1472-6882-10-561472-6882 . (PMID: 10.1186/1472-6882-10-561472-6882)
فهرسة مساهمة: Keywords: Markhamia lutea; anti-inflammatory; anti-oxidant; anti-ulcer; aqueous lyophilizate
المشرفين على المادة: 0 (Antioxidants)
0 (Anti-Inflammatory Agents)
0 (Plant Extracts)
0 (Anti-Ulcer Agents)
تواريخ الأحداث: Date Created: 20240509 Date Completed: 20240626 Latest Revision: 20240626
رمز التحديث: 20240627
DOI: 10.1515/jcim-2024-0059
PMID: 38721816
قاعدة البيانات: MEDLINE
الوصف
تدمد:1553-3840
DOI:10.1515/jcim-2024-0059