دورية أكاديمية
Anti-inflammatory, anti-oxidant and anti-ulcer activities of aqueous lyophilizate of Markhamia lutea (Bignoniaceae).
العنوان: | Anti-inflammatory, anti-oxidant and anti-ulcer activities of aqueous lyophilizate of Markhamia lutea (Bignoniaceae). |
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المؤلفون: | Chrétien NM; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Zenab Linda FN; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Brice Junior NN; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Marcelle Olga FY; Laboratory of Biology and Physiology of Animal Organisms, Department of Biology of Animal Organisms, Faculty of Science, The University of Douala Cameroon, Douala, Cameroon., Vanessa Mba MM; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Stephanie Flore DN; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Yacine Karelle MK; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Elvira NA; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Marius M; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon., Gilbert A; Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, 107819 University of Dschang , Douala, Cameroon. |
المصدر: | Journal of complementary & integrative medicine [J Complement Integr Med] 2024 May 10; Vol. 21 (2), pp. 248-257. Date of Electronic Publication: 2024 May 10 (Print Publication: 2024). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 101313855 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-3840 (Electronic) Linking ISSN: 15533840 NLM ISO Abbreviation: J Complement Integr Med Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2012-> : Berlin : Walter de Gruyter Original Publication: Berkeley, Calif. : Berkeley Electronic Press, 2004- |
مواضيع طبية MeSH: | Antioxidants*/pharmacology , Anti-Inflammatory Agents*/pharmacology , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Anti-Ulcer Agents*/pharmacology , Stomach Ulcer*/drug therapy , Stomach Ulcer*/chemically induced , Freeze Drying*, Animals ; Male ; Rats, Wistar ; Rats ; Mice |
مستخلص: | Objectives: This work was carried out with a view to determining the antioxidant, anti-inflammatory and anti-ulcer properties of the aqueous lyophilized extract of Markhamia lutea . Methods: In vitro proteinases inhibition, albumin denaturation, hemolysis of red blood cells by heat, inhibition of the proton pump H + /K + ATPase, FRAP (Ferric reducing antioxidant power) and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays were performed. In vivo , cold water immersion-induced ulceration and methylene blue-induced ulceration was used to determine the anti-ulcer properties of the lyophilizate (100, 200 and 300 mg/kg). Results: In vitro , the lyophilizate (400 μg/mL) significantly inhibited protein denaturation (66.65 %), hemolysis of red blood cells (56.54 %), proteinase activity (69.22 %); then the IC Conclusions: The aqueous lyophilizate of M. lutea has anti-ulcer properties thanks to its anti-inflammatory, antioxidant and anti-secretory properties. (© 2024 Walter de Gruyter GmbH, Berlin/Boston.) |
References: | Ruixue, L, Wenyuan, W, Yaping, M, Hong, C. Analysis of risk factors for ulcer recurrence and upper gastrointestinal bleeding in children with peptic ulcer treated with Helicobacter pylori eradication therapy. Transl Pediatr 2023;12:618–30. https://doi.org/10.21037/tp-23-155 . (PMID: 10.21037/tp-23-155) Dong-Qin, Z, Hua, X, Hai-Ji, S. Nervous mechanisms of restraint water-immersion stress-induced gastric mucosal lesion. World J Gastroenterol 2020;26:2533–49. https://doi.org/10.3748/wjg.v26.i20.2533 . (PMID: 10.3748/wjg.v26.i20.2533) Himani, G, Bhandari, U. Peptic ulcer and role of a polyherbal formulation in pathogenesis of ulcer in Wistar rats. J Sci Tech Res 2023;50:41894–900. Sufiyan, SA, Najmi, AK, Kaundal, M, Mohd, A. Gastroprotective effect of thymoquinone on water immersion restraint stress induced ulceration in rats. Drug Res 2017;67:2194–9379. Robles, TF, Carroll, JE. Restorative biological processes and health. Soc Pers Psychol Compass 2011;5:518–37. https://doi.org/10.1111/j.1751-9004.2011.00368.x . (PMID: 10.1111/j.1751-9004.2011.00368.x) Sahoo, N, Mingxue, G, Xiaoli, Z, Neel, R, Yang, J, Bekier, et al.. Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle. Dev Cell 2017;41:262–73. https://doi.org/10.1016/j.devcel.2017.04.003 . (PMID: 10.1016/j.devcel.2017.04.003) Câmara, R, Griessenauer, JR. Anatomy of the vagus nerve. Nerves Nerve Inj 2015;27:385–97. https://doi.org/10.1016/b978-0-12-410390-0.00028-7 . (PMID: 10.1016/b978-0-12-410390-0.00028-7) Mejia, A, Kraft, WK. Acid peptic diseases: pharmacological approach to treatment. Expert Rev Clin Pharmacol 2009;2:295–314. https://doi.org/10.1586/ecp.09.8 . (PMID: 10.1586/ecp.09.8) Hidekazu, S, Toshihiro, N, Hitoshi, T, Sachiko, M, Toshifumi, H. Roles of oxidative stress in stomach disorders. J Clin Biochem Nutr 2012;50:35–9. https://doi.org/10.3164/jcbn.11-115SR . (PMID: 10.3164/jcbn.11-115SR) Shah, DI, Dev, D, Santani, SS, Goswami, A. A novel use of methylene blue as a pharmacological tool. J Pharmacol Toxicol Methods 2006;54:273–7. https://doi.org/10.1016/j.vascn.2005.12.003 . (PMID: 10.1016/j.vascn.2005.12.003) Pfaffendroff, M, Brunning, TA, Batink, HD, Van Zwieten, PA. The interaction between methylene blue and the cholinergic system. Br J Pharmacol 1997;122:95–8. https://doi.org/10.1038/sj.bjp.0701355 . (PMID: 10.1038/sj.bjp.0701355) Coulibaly, L. Etude de la dispensation des antiulcereux dans les officines privées de nioro et de bamako. Thèse de doctorat. Université des sciences, des techniques et des technologies de bamako; 2020:88 p. Castillo, L, Diaz, M, Gonzalez-Coloma, A, Gonzalez, A, Alonso-Paz, E, Bassagoda, MJ, et al.. Clytostoma callistegioides (Bignoniaceae) wax extract with activity on aphid settling. Phytochemical 2010;71:2052–7. https://doi.org/10.1016/j.phytochem.2010.08.016 . (PMID: 10.1016/j.phytochem.2010.08.016) Fischer, E, Theisen, I, Lohmann, LG, Kadereit, JK. Bignoniaceae, flowering plants dicotyledons. The families and genera of vascular plants , Kubitzki, K, editor. Berlin: Springer Berlin Heidelberg; 2004, 7:9–13 pp. Tantangmo, F, Lenta, BN, Boyom, FF, Ngouela, S, Kaiser, M, Tsamo, E, et al.. Antiprotozoal activities of some constituents of Markhamia tomentosa (Bignoniaceae). Ann Trop Med Parasitol 2010;104:391–8. https://doi.org/10.1179/136485910x12743554760180 . (PMID: 10.1179/136485910x12743554760180) Lacroix, D, Prado, S, Deville, A, Krief, S, Dumontet, V, Kasenene, J, et al.. Hydroperoxy-cycloartane triterpenoids from the leaves of Markhamia lutea, a plant ingested by wild chimpanzees. Phytochemistry 2009;70:1239–45. https://doi.org/10.1016/j.phytochem.2009.06.020 . (PMID: 10.1016/j.phytochem.2009.06.020) Shaimaa, A, Sherweit, E, Nahla, A, Abdel, NS. Phytochemicals of Markhamia species (Bignoniaceae) and their therapeutic value. J Med Plants Res 2015;6:124–42. Joshi, KC, Singh, P, Sharma, MC. Quinones and other constituents of Markhamia platycalyx and bignonia unguiscati. J Nat Prod 1985;48:145. https://doi.org/10.1021/np50037a031 . (PMID: 10.1021/np50037a031) Mahmoud, BK, Hamed, AN, Samy, MN, Mostafa, EM, Wanas, AS, Radwan, MM, et al.. Phytochemical composition and antimicrobial properties of Markhamia platycalyx (Baker) Sprague leaf. Trop J Pharmaceut Res 2019;18:2623–31. Fagni, NZL, Mbiantcha, M, Djuichou Nguemnang, SF, Matah Marthe, VM, Yousseu, NW, Madjo Kouam, YK, et al.. Anti-helicobacter pylori, anti-inflammatory, and antioxidant activities of trunk bark of Alstonia boonei (Apocynaceae). BioMed Res Int 2022;2022:9022135. https://doi.org/10.1155/2022/9022135 . (PMID: 10.1155/2022/9022135) Sakat, S, Juvekar, ARG. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn I. J Pharm Pharmaceut Sci 2010;2:146–55. William, NY, Billong, MJR, Atsamo, AD, Tsafack, EG, Djuichou Nguemnang, SF, Fagni Njoya, ZL, et al.. In vitro and in vivo anti-inflammatory properties of the hydroethanolic extract of the roots of vernonia guineensis (Asteraceae). Int J Inflamm 2023;2023:7915367. https://doi.org/10.1155/2023/7915367 . (PMID: 10.1155/2023/7915367) Mensor, LL, Menezes, FS, Leitao, GG, Reis, AS, Dos Santos, TC, Coube, CS, et al.. Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytother Res 2001;15:127–30. https://doi.org/10.1002/ptr.687 . (PMID: 10.1002/ptr.687) Yassa, N, Razavi, HB, Hadjiakhoondi, A. Free radical scavenging and lipid peroxidation activity of the Shahani black grape. Pakistan J Biol Sci 2008;11:2513–16. https://doi.org/10.3923/pjbs.2008.2513.2516 . (PMID: 10.3923/pjbs.2008.2513.2516) Reyes-Chilpa, R, Baggio, CH, Alavez, D, Estrada-Muniza, E, Kauffmanc, FC, Sanchezc, RI, et al.. Inhibition of gastric H+, K+-ATPase by flavonoids, coumarins and xanthones isolated from Mexican medicinal plants. J Ethnopharmacol 2006;105:167–72. https://doi.org/10.1016/j.jep.2005.10.014 . (PMID: 10.1016/j.jep.2005.10.014) Dimo, T, Tsala, DE, Dzeufiet, DPD, Penlap, BV, Njifutie, N. Effects of alafia multiflora stapf on lipid peroxidation and antioxidant enzyme status in carbon tetrachloride-treated rats. Pharmacologyonline 2006;2:76–89. Fermor, B, Christensen, SE, Youn, I, Cernanec, JM, Davies, CM, Weinberg, JB. Oxygen, nitric oxide and articular cartilage. Eur Cell Mater 2007;13:56–65. https://doi.org/10.22203/ecm.v013a06 . (PMID: 10.22203/ecm.v013a06) Kebieche, M. Activité biochimique des extraits flavonoidiques de la plante Ranunculus repens L: Effet sur le diabète expérimental et l’hépatotoxicité induite par l’Epirubicine. Biochimie, These de Doctorat. Université Mentouri Constantine 2009:143 p. Okoli, CO, Akah, PA, Onuoha, NJ, Okoye, TC, Nwoye, AC, Nworu, CS. Acanthus montanus: an experimental evaluation of the antimicrobial, anti-inflammatory and immunological properties of a traditional remedy for furuncles. BMC Compl Alternative Med 2008;6:27. https://doi.org/10.1186/1472-6882-8-27 . (PMID: 10.1186/1472-6882-8-27) Leelaprakash, G, Mohan-Dass, S. In vitro anti-inflammatory activity of methanol extract of Enicostemma axillare. Int J Drug Dev Res 2011;3:189–96. Ruiz-Ruiz, JC, Matus-Basto, AJ, Acereto-Escoffié, P, Rubí, M. Antioxidant and anti-inflammatory activities of phenolic compounds isolated from Melipona beecheii honey Segura-Campos. Food Agric Immunol 2017;28:1424–37. https://doi.org/10.1080/09540105.2017.1347148 . (PMID: 10.1080/09540105.2017.1347148) Gunathilake, KDPP, Ranaweera, KKDS, Vasantha Rupasinghe, HP. In vitro anti-inflammatory properties of selected green leafy vegetables. Biomedicines 2018;6:107. https://doi.org/10.3390/biomedicines6040107 . (PMID: 10.3390/biomedicines6040107) Umapathy, E, Ndebia, EJ, Meeme, A, Adam, B, Menziwa, P, Nkeh-Chungag, BN, et al.. An experimental evaluation of Albuca setosa aqueous extract on membrane stabilization, protein denaturation and white blood cell migration during acute inflammation. J Med Plants Res 2010;4:789–95. Umamaheswari, M, Chatterjee, TK. In vitro antioxidant activities of the fractions of Coccinnia grandis L. leaf extract. Afr J Tradit, Complementary Altern Med 2008;5:61–73. https://doi.org/10.4314/ajtcam.v5i1.31258 . (PMID: 10.4314/ajtcam.v5i1.31258) Saha, AK, Rahman, MR, Shahriar, M, Azad, NA, Das, S. Screening of six ayurvedic medicinal plant extracts for antioxidant and cytotoxic activity. J Pharmacogn Phytochem 2013;2:181–8. El-Chaghaby, GA, Ahmad, AF, Ramis, ES. Evaluation of the antioxidant and antibacterial properties of various solvents extracts of Annona squamosa L. leaves. Arab J Chem 2014;7:227–33. https://doi.org/10.1016/j.arabjc.2011.06.019 . (PMID: 10.1016/j.arabjc.2011.06.019) Yousseu, NW, Ateufack, G, Abdul, JS, Mbiantcha, M, Tchoumba, TLM, Matah Mba, MV, et al.. Extracts from the trunk bark of Distemonanthus benthamianus Baillon. (Caesalpiniaceae) developed antidiarrhoeal activities in rats and mice. Orient Pharm Exp Med 2019;19:421–33. https://doi.org/10.1007/s13596-019-00385-x . (PMID: 10.1007/s13596-019-00385-x) Shan, L, Wu, D, Guibo, S, Funeng, G, Yongmei, S, Tand, J, et al.. Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival. Pharm Biol 2019;57:770–7. https://doi.org/10.1080/13880209.2019.1682620 . (PMID: 10.1080/13880209.2019.1682620) Plummer, MP, Blaser, AR, Deane, AM. Stress ulceration: prevalence, pathology and association with adverse outcomes. Crit Care 2014;18:213. https://doi.org/10.1186/cc13780 . (PMID: 10.1186/cc13780) Faezeh, T, Abbas, A, Sareh, K, Si, L, Nur’ain, B, Gokula, M. Ulcer prevention effect of 3,4,5-Tihydroxy-N0-[(2-Methyl-1H-Indol 3yl) Methylidene] benzohydrazide in HCl/ethanol-induced gastric mucosal damage in rats. Int J Med Sci 2017;14:17–26. Furutani, K, Aihara, T, Nakamura, E, Tanaka, S, Ichikawa, A, Ohtsu, H, et al.. Crucial role of histamine for regulation of gastric acid secretion ascertained by histidine decarboxylase-knockout mice. J Pharmacol Exp Therapeut 2003;307:331–8. https://doi.org/10.1124/jpet.103.052019 . (PMID: 10.1124/jpet.103.052019) Aihara, T, Nakamura, E, Amagase, K, Tomita, K, Fujishita, T, Furutani, K, et al.. Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future. Pharmacol Therapeut 2005;98:109–27. https://doi.org/10.1016/s0163-7258(03)00015-9 . (PMID: 10.1016/s0163-7258(03)00015-9) Heloina de, SF, Leite, AJ, Barbosa-Filho, JM, Filgueiras de Athayde, FP, Célia de Oliveira, CM, Moura, MD, et al.. Gastric and duodenal antiulcer activity of alkaloids. Rev Mol 2008;13:3198–223. El-Zaatari, M, Yana, Z, Tessier, A, Waghray, M, Lentz, S, Gumucio, D, et al.. Intracellular calcium-release and protein kinase C-activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology 2010;139:2061–71. https://doi.org/10.1053/j.gastro.2010.08.047 . (PMID: 10.1053/j.gastro.2010.08.047) Sandu, C, Artunc, F, Grahammer, F, Rotte, A, Boini, KM, Friedrich, B, et al.. Role of the serum and glucocorticoid inducible kinase SGK1 in glucocorticoid stimulation of gastric acid secretion. Pflügers Archiv 2007;455:493–503. https://doi.org/10.1007/s00424-007-0305-4 . (PMID: 10.1007/s00424-007-0305-4) Rizzi, PA. Les troubles digestifs liés au stress: considérations psychosomatiques et prise en charge à l’offcine. Thèse de doctorat. Université de LORRAINE; 2016:139 p. Kudryavtsev, KV, Markevich, AO, Oleksandr, VV, Tetyana, MF, Tetyana, VB, Lyudmyla, IO, et al.. Pharmacological correction of stress-induced gastric ulceration by novel small-molecule agents with antioxidant profile. Sci World J 2014;2014:6. Fornai, M, Colucci, R, Antonioli, L, Awwad, O, Ugolini, C, Tuccori, M, et al.. Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: characterization of molecular mechanisms. Pharmacol Res 2011;63:59–67. https://doi.org/10.1016/j.phrs.2010.10.013 . (PMID: 10.1016/j.phrs.2010.10.013) Matah, MMV, Ateufack, G, Mbiantcha, M, Atsamo, AD, Adjouzem, FC, Djuichou, SF, et al.. Methanolic extract of distemonanthus benthamianus (caesalpiniaceae) stem bark suppresses ethanol/indomethacin induced chronic gastric injury in rats. Gastroenterol Res Pract 2020;2020:14. Boulaiche, H, Boulchefar, L, Bouldjadj, S. Effet antioxydant et néphroprotecteur du thé vert (Camellia sinensis) (Revue systématique). Mémoire de Master, Université Mohammed Seddik Ben Yahia Jijel. Algérie 2020;2020:71. Townsend, DM, Tew, KD, Tapiero, H. The importance of glutathione in human disease. Biomed Pharmacother 2003;57:144–55. https://doi.org/10.1016/s0753-3322(03)00043-x . (PMID: 10.1016/s0753-3322(03)00043-x) Ateufack, G, Matah, M, Tchoumbou, H, Yousseu, NW, Dongmo, F, Adjouzem, C, et al.. Preventive and curative properties of aqueous and methanolic extracts of Distemonanthus benthamianus stem barks on acute and chronic gastric ulcers in male rats. Eur J Pharm Med Res 2018;5:402–13. Rashedunnabi, A, In-Shik, K, Dongchoon, A, Hyun-Jin, T, Hyeon-Hwa, N, Byung-Kil, C, et al.. Anti-inflammatory and gastroprotective roles of rabdosia inflexa through downregulation of pro-inflammatory cytokines and MAPK/NF-κB signaling pathways. Int J Mol Sci 2018;19:584. https://doi.org/10.3390/ijms19020584 . (PMID: 10.3390/ijms19020584) Ekambaram, S, Senthami, S, Venkataraman, S. Evaluation of antiarthritic activity of Strychnos potarum linn seeds in Freund’s adjuvant-induced arthritic rat model. BMC Compl Alternative Med 2010;10:1–9. https://doi.org/10.1186/1472-6882-10-561472-6882 . (PMID: 10.1186/1472-6882-10-561472-6882) |
فهرسة مساهمة: | Keywords: Markhamia lutea; anti-inflammatory; anti-oxidant; anti-ulcer; aqueous lyophilizate |
المشرفين على المادة: | 0 (Antioxidants) 0 (Anti-Inflammatory Agents) 0 (Plant Extracts) 0 (Anti-Ulcer Agents) |
تواريخ الأحداث: | Date Created: 20240509 Date Completed: 20240626 Latest Revision: 20240626 |
رمز التحديث: | 20240627 |
DOI: | 10.1515/jcim-2024-0059 |
PMID: | 38721816 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1553-3840 |
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DOI: | 10.1515/jcim-2024-0059 |