دورية أكاديمية
أعرض في EDS

Topical antimicrobial treatment of mesh for the reduction of surgical site infections after hernia repair: a systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Topical antimicrobial treatment of mesh for the reduction of surgical site infections after hernia repair: a systematic review and meta-analysis.
المؤلفون: Bontekoning N; Department of Surgery, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology & Metabolism, Amsterdam, The Netherlands., Huizing NJ; Department of Surgery, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Timmer AS; Department of Surgery, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology & Metabolism, Amsterdam, The Netherlands., Groenen H; Department of Surgery, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology & Metabolism, Amsterdam, The Netherlands., de Jonge SW; Department of Surgery, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology & Metabolism, Amsterdam, The Netherlands., Boermeester MA; Department of Surgery, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands. m.a.boermeester@amsterdamumc.nl.; Amsterdam Gastroenterology Endocrinology & Metabolism, Amsterdam, The Netherlands. m.a.boermeester@amsterdamumc.nl.
المصدر: Hernia : the journal of hernias and abdominal wall surgery [Hernia] 2024 Jun; Vol. 28 (3), pp. 691-700. Date of Electronic Publication: 2024 May 09.
نوع المنشور: Journal Article; Systematic Review; Meta-Analysis; Review
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: France NLM ID: 9715168 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1248-9204 (Electronic) Linking ISSN: 12489204 NLM ISO Abbreviation: Hernia Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Paris, France : Springer, c1997-
مواضيع طبية MeSH: Surgical Wound Infection*/prevention & control , Surgical Wound Infection*/etiology , Surgical Mesh*/adverse effects , Herniorrhaphy*/adverse effects, Humans ; Administration, Topical ; Anti-Infective Agents/administration & dosage ; Anti-Bacterial Agents/administration & dosage
مستخلص: Purpose: Use of mesh is essential in hernia repair. A common complication after hernia repair is surgical site infection (SSI), which poses a risk in spreading to the mesh, possibly causing mesh infection. Topical antimicrobial pretreatment of mesh may potentially reduce SSI risk in hernia repair and has shown promising results in in vitro and in vivo studies. Clinical evidence, however, is more important. This systematic review aims to provide an overview of available clinical evidence for antimicrobial pretreated mesh in hernia repair surgery to reduce SSI.
Methods: We report in accordance with PRISMA guidelines. CENTRAL, EMBASE, CINAHL and PubMed were searched up to October 2023 for studies that investigated the use of antimicrobial pretreated mesh on SSI incidence in adults undergoing hernia repair. The primary outcome was SSI incidence. We also collected data on pathogen involvement, hernia recurrence, and mesh infection. A meta-analysis on SSI risk and GRADE-assessment was performed of eligible studies.
Results: We identified 11 eligible studies (n = 2660 patients); 5 randomized trials and 6 cohort studies. Investigated interventions included pre-coated mesh, antibiotic carriers, mesh soaked or irrigated with antibiotic or antiseptic solution. Meta-analysis showed no significant reduction in SSI for antibiotic pretreated polypropylene mesh (RR 0.76 [95% CI 0.27; 2.09]; I 2 50%).
Conclusion: Data on topical mesh pretreatment to reduce SSI risk after hernia repair is limited. Very low certainty evidence from randomized trials in hernia repair surgery shows no significant benefit for antibiotic mesh pretreatment for SSI reduction, but data are imprecise due to optimal information size not being met.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Antibiotics; Antimicriobials; Mesh; Pretreatment; Surgical site infection; Topical
المشرفين على المادة: 0 (Anti-Infective Agents)
0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20240509 Date Completed: 20240715 Latest Revision: 20240718
رمز التحديث: 20240718
مُعرف محوري في PubMed: PMC11249405
DOI: 10.1007/s10029-024-02987-0
PMID: 38722398
قاعدة البيانات: MEDLINE
الوصف
تدمد:1248-9204
DOI:10.1007/s10029-024-02987-0