دورية أكاديمية
Diagnostic patterns of serum inflammatory protein markers in children with Lyme neuroborreliosis.
| العنوان: | Diagnostic patterns of serum inflammatory protein markers in children with Lyme neuroborreliosis. |
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| المؤلفون: | Fredriksson T; Medical Programme, Faculty of Medicine and Health Sciences, Linköping University, Sweden., Brudin L; Department of Clinical Physiology, Region Kalmar County, Kalmar, Sweden; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Henningsson AJ; Department of Laboratory Medicine, Division of Clinical Microbiology; Region Jönköping County, Jönköping and Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden., Skogman BH; Center for Clinical Research Dalarna, Region Dalarna, Falun and Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Tjernberg I; Department of Clinical Chemistry and Transfusion Medicine, Region Kalmar County, Kalmar and Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden. Electronic address: ivar.tjernberg@liu.se. |
| المصدر: | Ticks and tick-borne diseases [Ticks Tick Borne Dis] 2024 Jul; Vol. 15 (4), pp. 102349. Date of Electronic Publication: 2024 May 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101522599 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-9603 (Electronic) Linking ISSN: 1877959X NLM ISO Abbreviation: Ticks Tick Borne Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, 2010- |
| مواضيع طبية MeSH: | Lyme Neuroborreliosis*/diagnosis , Lyme Neuroborreliosis*/blood , Lyme Neuroborreliosis*/cerebrospinal fluid , Biomarkers*/blood, Humans ; Child ; Male ; Female ; Adolescent ; Child, Preschool |
| مستخلص: | Definite diagnosis of Lyme neuroborreliosis (LNB) requires investigation of serum and cerebrospinal fluid (CSF). Thus, lumbar puncture is necessary, and requires administration of sedating drugs in children. This study aimed to investigate if a pattern of different inflammatory biomarkers in serum could contribute to the selection of children for lumbar puncture in suspected LNB. Patients were included from a cohort of children who was previously investigated for LNB including serum and CSF sampling during the years 2010-2014. The multiplex proximity extension assay (PEA) inflammation panel Target 96 (Olink Bioscience, Uppsala, Sweden) was used to examine 92 biomarkers in serum. Based on the presence of CSF pleocytosis and Borrelia-specific antibodies, patients were divided into a definite LNB group (n=61) and a non-LNB control group (n=58). Following PEA and statistical analysis with multivariate logistic regression, five biomarkers remained significant (p < 0.001), which were included in a calculation of protein index. The index biomarkers were CST5, IL-15RA, CXCL10, DNER and CX3CL1. A receiver operating characteristic curve was constructed from the index, which showed an 80 % sensitivity and 81 % specificity. Area under the curve was 0.889. We offer evidence that, with further refinements, patterns of serum biomarkers might help identify those children more or less likely to have LNB, perhaps ultimately decreasing the need for lumbar punctures. Competing Interests: Declaration of competing interest IT reports participation in advisory board and personal fees from Pfizer Inc outside the submitted work. AJH reports recent research collaborative agreements with Abbott Laboratories and Reagena Ltd, not related to this study. (Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biomarker; Children; Diagnosis; Lyme neuroborreliosis; Protein; Serum |
| تواريخ الأحداث: | Date Created: 20240509 Date Completed: 20240518 Latest Revision: 20240518 |
| رمز التحديث: | 20240519 |
| DOI: | 10.1016/j.ttbdis.2024.102349 |
| PMID: | 38723400 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1877-9603 |
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| DOI: | 10.1016/j.ttbdis.2024.102349 |