دورية أكاديمية
أعرض في EDS

Association between triglyceride glucose-body mass index and long-term adverse outcomes of heart failure patients with coronary heart disease.

التفاصيل البيبلوغرافية
العنوان: Association between triglyceride glucose-body mass index and long-term adverse outcomes of heart failure patients with coronary heart disease.
المؤلفون: Lyu L; Department of Cardiology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.; Medical School of Chinese PLA, Beijing, China., Wang X; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Xu J; Department of General Surgery, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, China., Liu Z; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., He Y; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Zhu W; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Lin L; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Hao B; Department of Cardiology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China. haobch301@163.com.; Medical School of Chinese PLA, Beijing, China. haobch301@163.com., Liu H; Department of Cardiology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China. liuhbcad301@163.com.
المصدر: Cardiovascular diabetology [Cardiovasc Diabetol] 2024 May 09; Vol. 23 (1), pp. 162. Date of Electronic Publication: 2024 May 09.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2002-
مواضيع طبية MeSH: Heart Failure*/mortality , Heart Failure*/blood , Heart Failure*/diagnosis , Triglycerides*/blood , Body Mass Index* , Blood Glucose*/metabolism , Biomarkers*/blood , Coronary Disease*/mortality , Coronary Disease*/blood , Coronary Disease*/diagnosis , Coronary Disease*/epidemiology , Patient Readmission*, Humans ; Male ; Female ; Middle Aged ; Aged ; Prospective Studies ; Time Factors ; Risk Assessment ; Risk Factors ; Prognosis ; Cause of Death ; Insulin Resistance ; Predictive Value of Tests
مستخلص: Background: The triglyceride glucose-body mass index (TyG-BMI) is recognized as a reliable surrogate for evaluating insulin resistance and an effective predictor of cardiovascular disease. However, the link between TyG-BMI index and adverse outcomes in heart failure (HF) patients remains unclear. This study examines the correlation of the TyG-BMI index with long-term adverse outcomes in HF patients with coronary heart disease (CHD).
Methods: This single-center, prospective cohort study included 823 HF patients with CHD. The TyG-BMI index was calculated as follows: ln [fasting triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2] × BMI. To explore the association between the TyG-BMI index and the occurrences of all-cause mortality and HF rehospitalization, we utilized multivariate Cox regression models and restricted cubic splines with threshold analysis.
Results: Over a follow-up period of 9.4 years, 425 patients died, and 484 were rehospitalized due to HF. Threshold analysis revealed a significant reverse "J"-shaped relationship between the TyG-BMI index and all-cause mortality, indicating a decreased risk of all-cause mortality with higher TyG-BMI index values below 240.0 (adjusted model: HR 0.90, 95% CI 0.86-0.93; Log-likelihood ratio p = 0.003). A distinct "U"-shaped nonlinear relationship was observed with HF rehospitalization, with the inflection point at 228.56 (adjusted model: below: HR 0.95, 95% CI 0.91-0.98; above: HR 1.08, 95% CI 1.03-1.13; Log-likelihood ratio p < 0.001).
Conclusions: This study reveals a nonlinear association between the TyG-BMI index and both all-cause mortality and HF rehospitalization in HF patients with CHD, positioning the TyG-BMI index as a significant prognostic marker in this population.
(© 2024. The Author(s).)
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معلومات مُعتمدة: No.22BJZ26 the Special Project of Health Care
فهرسة مساهمة: Keywords: All-cause mortality; Heart failure; Heart failure rehospitalization; Nonlinear association; Triglyceride glucose-body mass index
المشرفين على المادة: 0 (Triglycerides)
0 (Blood Glucose)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240509 Date Completed: 20240510 Latest Revision: 20240512
رمز التحديث: 20240512
مُعرف محوري في PubMed: PMC11080126
DOI: 10.1186/s12933-024-02213-2
PMID: 38724999
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-2840
DOI:10.1186/s12933-024-02213-2