دورية أكاديمية
Comprehensive microRNA expression analysis of pediatric gonadal germ cell tumors: unveiling novel biomarkers and signatures.
العنوان: | Comprehensive microRNA expression analysis of pediatric gonadal germ cell tumors: unveiling novel biomarkers and signatures. |
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المؤلفون: | Santarosa Vieira AG; Barretos Children's Cancer Hospital from Hospital de Amor, Brazil.; Brazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), São Paulo, Brazil.; Pediatric Cancerology's Department of Santa Casa de Misericórdia de Santos, Brazil., da Silva LS; Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil., Albino da Silva EC; Department of Pathology, Barretos Cancer Hospital, Brazil., Laus AC; Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil., Faria TMV; Barretos Children's Cancer Hospital from Hospital de Amor, Brazil., van Helvoort Lengert A; Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil., Martins GE; Barretos Children's Cancer Hospital from Hospital de Amor, Brazil.; Brazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), São Paulo, Brazil., de Oliveira MA; Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil.; Life and Health Sciences Research Institute (ICVS), Medical School, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga, Portugal., Lopes LF; Barretos Children's Cancer Hospital from Hospital de Amor, Brazil.; Brazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), São Paulo, Brazil., Pinto MT; Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil.; Pediatric Oncology Research Group (GPOPed), Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil. |
المصدر: | Molecular oncology [Mol Oncol] 2024 Jun; Vol. 18 (6), pp. 1593-1607. Date of Electronic Publication: 2024 May 09. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101308230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0261 (Electronic) Linking ISSN: 15747891 NLM ISO Abbreviation: Mol Oncol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2017- : Hoboken, New Jersey : John Wiley & Sons, Inc. Original Publication: Amsterdam : Elsevier |
مواضيع طبية MeSH: | MicroRNAs*/genetics , MicroRNAs*/metabolism , Neoplasms, Germ Cell and Embryonal*/genetics , Neoplasms, Germ Cell and Embryonal*/metabolism , Neoplasms, Germ Cell and Embryonal*/pathology , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/metabolism , Gene Expression Regulation, Neoplastic*, Humans ; Child ; Male ; Female ; Adolescent ; Child, Preschool ; Gene Expression Profiling ; Infant ; Testicular Neoplasms/genetics ; Testicular Neoplasms/metabolism ; Testicular Neoplasms/pathology |
مستخلص: | microRNAs (miRNAs) are small endogenous noncoding RNAs, and alterations in their expression may contribute to oncogenesis. Discovering a unique miRNA pattern holds the potential for early detection and novel treatment possibilities in cancer. This study aimed to evaluate miRNA expression in pediatric patients with gonadal germ cell tumors (GCTs), focusing on characterizing the miRNA profiles of each histological subtype and identifying a distinct histological miRNA signature for a total of 42 samples of pediatric gonadal GCTs. The analysis revealed distinct miRNA expression profiles for all histological types, regardless of the primary site. We identified specific miRNA expression signatures for each histological type, including 34 miRNAs for dysgerminomas, 13 for embryonal carcinomas, 25 for yolk sac tumors, and one for immature teratoma, compared to healthy controls. Furthermore, we identified 26 miRNAs that were commonly expressed in malignant tumors, with six miRNAs (miR-302a-3p, miR-302b-3p, miR-371a-5p, miR-372-3p, miR-373-3p, and miR-367-3p) showing significant overexpression. Notably, miR-302b-3p exhibited a significant association with all the evaluated clinical features. Our findings suggest that miRNAs have the potential to aid in the diagnosis, prognosis, and management of patients with malignant GCTs. (© 2024 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.) |
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فهرسة مساهمة: | Keywords: biomarkers; germ cell tumor; microRNA; ovarian cancer; pediatric cancer; testicular cancer |
المشرفين على المادة: | 0 (MicroRNAs) 0 (Biomarkers, Tumor) |
تواريخ الأحداث: | Date Created: 20240510 Date Completed: 20240608 Latest Revision: 20240610 |
رمز التحديث: | 20240610 |
مُعرف محوري في PubMed: | PMC11161733 |
DOI: | 10.1002/1878-0261.13617 |
PMID: | 38725152 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1878-0261 |
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DOI: | 10.1002/1878-0261.13617 |