دورية أكاديمية
أعرض في EDS

Comprehensive microRNA expression analysis of pediatric gonadal germ cell tumors: unveiling novel biomarkers and signatures.

التفاصيل البيبلوغرافية
العنوان: Comprehensive microRNA expression analysis of pediatric gonadal germ cell tumors: unveiling novel biomarkers and signatures.
المؤلفون: Santarosa Vieira AG; Barretos Children's Cancer Hospital from Hospital de Amor, Brazil.; Brazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), São Paulo, Brazil.; Pediatric Cancerology's Department of Santa Casa de Misericórdia de Santos, Brazil., da Silva LS; Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil., Albino da Silva EC; Department of Pathology, Barretos Cancer Hospital, Brazil., Laus AC; Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil., Faria TMV; Barretos Children's Cancer Hospital from Hospital de Amor, Brazil., van Helvoort Lengert A; Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil., Martins GE; Barretos Children's Cancer Hospital from Hospital de Amor, Brazil.; Brazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), São Paulo, Brazil., de Oliveira MA; Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil.; Life and Health Sciences Research Institute (ICVS), Medical School, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga, Portugal., Lopes LF; Barretos Children's Cancer Hospital from Hospital de Amor, Brazil.; Brazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), São Paulo, Brazil., Pinto MT; Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil.; Pediatric Oncology Research Group (GPOPed), Molecular Oncology Research Center, Barretos Cancer Hospital, Brazil.
المصدر: Molecular oncology [Mol Oncol] 2024 Jun; Vol. 18 (6), pp. 1593-1607. Date of Electronic Publication: 2024 May 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101308230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0261 (Electronic) Linking ISSN: 15747891 NLM ISO Abbreviation: Mol Oncol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2017- : Hoboken, New Jersey : John Wiley & Sons, Inc.
Original Publication: Amsterdam : Elsevier
مواضيع طبية MeSH: MicroRNAs*/genetics , MicroRNAs*/metabolism , Neoplasms, Germ Cell and Embryonal*/genetics , Neoplasms, Germ Cell and Embryonal*/metabolism , Neoplasms, Germ Cell and Embryonal*/pathology , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/metabolism , Gene Expression Regulation, Neoplastic*, Humans ; Child ; Male ; Female ; Adolescent ; Child, Preschool ; Gene Expression Profiling ; Infant ; Testicular Neoplasms/genetics ; Testicular Neoplasms/metabolism ; Testicular Neoplasms/pathology
مستخلص: microRNAs (miRNAs) are small endogenous noncoding RNAs, and alterations in their expression may contribute to oncogenesis. Discovering a unique miRNA pattern holds the potential for early detection and novel treatment possibilities in cancer. This study aimed to evaluate miRNA expression in pediatric patients with gonadal germ cell tumors (GCTs), focusing on characterizing the miRNA profiles of each histological subtype and identifying a distinct histological miRNA signature for a total of 42 samples of pediatric gonadal GCTs. The analysis revealed distinct miRNA expression profiles for all histological types, regardless of the primary site. We identified specific miRNA expression signatures for each histological type, including 34 miRNAs for dysgerminomas, 13 for embryonal carcinomas, 25 for yolk sac tumors, and one for immature teratoma, compared to healthy controls. Furthermore, we identified 26 miRNAs that were commonly expressed in malignant tumors, with six miRNAs (miR-302a-3p, miR-302b-3p, miR-371a-5p, miR-372-3p, miR-373-3p, and miR-367-3p) showing significant overexpression. Notably, miR-302b-3p exhibited a significant association with all the evaluated clinical features. Our findings suggest that miRNAs have the potential to aid in the diagnosis, prognosis, and management of patients with malignant GCTs.
(© 2024 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
References: Cell. 2006 Mar 24;124(6):1169-81. (PMID: 16564011)
J Clin Oncol. 2019 Jun 1;37(16):1412-1423. (PMID: 30875280)
Cancer. 2010 Oct 15;116(20):4882-91. (PMID: 20597129)
Ann Oncol. 2000 Mar;11(3):263-71. (PMID: 10811491)
CA Cancer J Clin. 2020 Jan;70(1):7-30. (PMID: 31912902)
Bioinformatics. 2012 Jun 1;28(11):1546-8. (PMID: 22513995)
Onco Targets Ther. 2019 May 21;12:4013-4023. (PMID: 31190897)
Epigenetics. 2021 Jan-Feb;16(2):162-176. (PMID: 32615059)
Neuro Oncol. 2018 Mar 27;20(4):519-530. (PMID: 29036598)
J Biochem. 2020 Jul 1;168(1):83-91. (PMID: 32211853)
Mutat Res. 2011 Dec 1;717(1-2):1-8. (PMID: 21458467)
J Pathol. 2007 Nov;213(3):319-28. (PMID: 17893849)
Cancer Biomark. 2020;28(3):351-363. (PMID: 32417760)
Blood. 2006 Dec 1;108(12):3646-53. (PMID: 16882713)
Oncol Lett. 2018 Jun;15(6):9884-9888. (PMID: 29928360)
Mol Cancer Res. 2019 Jan;17(1):299-309. (PMID: 30266753)
Adv Urol. 2018 Feb 4;2018:9059382. (PMID: 29515628)
J Pediatr Hematol Oncol. 2012 Oct;34(7):e301-3. (PMID: 22430587)
Clin Genitourin Cancer. 2019 Aug;17(4):e733-e744. (PMID: 31155478)
Asian Pac J Cancer Prev. 2020 Feb 01;21(2):391-397. (PMID: 32102516)
Turk J Urol. 2019 Nov 29;46(1):26-30. (PMID: 31905122)
BMC Pulm Med. 2017 May 26;17(1):86. (PMID: 28549458)
Korean J Radiol. 2021 Oct;22(10):1650-1657. (PMID: 34402242)
Mol Clin Oncol. 2019 Aug;11(2):201-207. (PMID: 31316774)
Pediatr Blood Cancer. 2004 Feb;42(2):169-75. (PMID: 14752882)
Neuro Oncol. 2012 May;14(5):596-612. (PMID: 22411914)
Sci Rep. 2019 Jun 24;9(1):9189. (PMID: 31235829)
BMC Cancer. 2020 Feb 22;20(1):143. (PMID: 32087690)
Acta Oncol. 2000;39(4):509-17. (PMID: 11041114)
Bioinformatics. 2016 Sep 15;32(18):2847-9. (PMID: 27207943)
Lancet. 2006 Mar 4;367(9512):754-65. (PMID: 16517276)
Am J Clin Pathol. 2011 Jan;135(1):119-25. (PMID: 21173133)
Int J Oncol. 2017 Feb;50(2):356-364. (PMID: 28000896)
Cancer Res. 2010 Apr 1;70(7):2911-23. (PMID: 20332240)
Biomed Res Int. 2019 May 28;2019:5030349. (PMID: 31275973)
J Biol Chem. 2013 Aug 16;288(33):23990-9. (PMID: 23843459)
Surg Pathol Clin. 2019 Jun;12(2):621-649. (PMID: 31097117)
J Urol. 2021 Jan;205(1):137-144. (PMID: 32856980)
Cancer Epidemiol. 2020 Apr;65:101669. (PMID: 31955037)
Curr Protoc Mol Biol. 2011 Apr;Chapter 25:Unit25B.10. (PMID: 21472696)
Genome Biol. 2013 Apr 29;14(4):R34. (PMID: 23618380)
J Urol. 2015 Jan;193(1):331-7. (PMID: 25046619)
Front Oncol. 2020 Feb 21;10:181. (PMID: 32154175)
Biopreserv Biobank. 2019 Oct;17(5):444-451. (PMID: 31194576)
فهرسة مساهمة: Keywords: biomarkers; germ cell tumor; microRNA; ovarian cancer; pediatric cancer; testicular cancer
المشرفين على المادة: 0 (MicroRNAs)
0 (Biomarkers, Tumor)
تواريخ الأحداث: Date Created: 20240510 Date Completed: 20240608 Latest Revision: 20240610
رمز التحديث: 20240610
مُعرف محوري في PubMed: PMC11161733
DOI: 10.1002/1878-0261.13617
PMID: 38725152
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-0261
DOI:10.1002/1878-0261.13617