دورية أكاديمية
أعرض في EDS

Increased ER Stress and Unfolded Protein Response Activation in Epithelial and Inflammatory Cells in Hypersensitivity Pneumonitis.

التفاصيل البيبلوغرافية
العنوان: Increased ER Stress and Unfolded Protein Response Activation in Epithelial and Inflammatory Cells in Hypersensitivity Pneumonitis.
المؤلفون: Cabrera S; Laboratorio de Fibrosis, Unidad de Biopatología Pulmonar, Ciencias-INER, Universidad Nacional Autónoma de México, México City, México., García-Vicente Á; Laboratorio de Fibrosis, Unidad de Biopatología Pulmonar, Ciencias-INER, Universidad Nacional Autónoma de México, México City, México., Gutiérrez P; Laboratorio de Fibrosis, Unidad de Biopatología Pulmonar, Ciencias-INER, Universidad Nacional Autónoma de México, México City, México., Sánchez A; Laboratorio de Fibrosis, Unidad de Biopatología Pulmonar, Ciencias-INER, Universidad Nacional Autónoma de México, México City, México., Gaxiola M; Instituto Nacional de Enfermedades Respiratorias 'Ismael Cosío Villegas,' Mexico City, México., Rodríguez-Bobadilla C; Laboratorio de Fibrosis, Unidad de Biopatología Pulmonar, Ciencias-INER, Universidad Nacional Autónoma de México, México City, México., Selman M; Instituto Nacional de Enfermedades Respiratorias 'Ismael Cosío Villegas,' Mexico City, México., Pardo A; Laboratorio de Fibrosis, Unidad de Biopatología Pulmonar, Ciencias-INER, Universidad Nacional Autónoma de México, México City, México.
المصدر: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society [J Histochem Cytochem] 2024 May; Vol. 72 (5), pp. 289-307. Date of Electronic Publication: 2024 May 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9815334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1551-5044 (Electronic) Linking ISSN: 00221554 NLM ISO Abbreviation: J Histochem Cytochem Subsets: MEDLINE
أسماء مطبوعة: Publication: <2011->: Thousand Oaks, CA : SAGE Publications
Original Publication: Baltimore : Williams & Wilkins Co., c1953-
مواضيع طبية MeSH: Endoplasmic Reticulum Chaperone BiP* , Unfolded Protein Response* , Alveolitis, Extrinsic Allergic*/pathology , Alveolitis, Extrinsic Allergic*/immunology , Alveolitis, Extrinsic Allergic*/metabolism , Endoplasmic Reticulum Stress* , X-Box Binding Protein 1*/metabolism , X-Box Binding Protein 1*/genetics , Heat-Shock Proteins*/metabolism , Transcription Factor CHOP*/metabolism , Epithelial Cells*/metabolism , Epithelial Cells*/pathology, Animals ; Humans ; Mice ; Female ; Male ; Lung/pathology ; Lung/immunology ; Lung/metabolism ; DNA-Binding Proteins/metabolism ; Regulatory Factor X Transcription Factors/metabolism ; Transcription Factors/metabolism ; Disease Models, Animal ; Middle Aged ; Mice, Inbred C57BL ; Adult ; Inflammation/pathology ; Inflammation/metabolism ; Inflammation/immunology
مستخلص: Several types of cytotoxic insults disrupt endoplasmic reticulum (ER) homeostasis, cause ER stress, and activate the unfolded protein response (UPR). The role of ER stress and UPR activation in hypersensitivity pneumonitis (HP) has not been described. HP is an immune-mediated interstitial lung disease that develops following repeated inhalation of various antigens in susceptible and sensitized individuals. The aim of this study was to investigate the lung expression and localization of the key effectors of the UPR, BiP/GRP78, CHOP, and sXBP1 in HP patients compared with control subjects. Furthermore, we developed a mouse model of HP to determine whether ER stress and UPR pathway are induced during this pathogenesis. In human control lungs, we observed weak positive staining for BiP in some epithelial cells and macrophages, while sXBP1 and CHOP were negative. Conversely, strong BiP, sXBP1- and CHOP-positive alveolar and bronchial epithelial, and inflammatory cells were identified in HP lungs. We also found apoptosis and autophagy markers colocalization with UPR proteins in HP lungs. Similar results were obtained in lungs from an HP mouse model. Our findings suggest that the UPR pathway is associated with the pathogenesis of HP.
Competing Interests: Competing InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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فهرسة مساهمة: Keywords: ER stress; Saccaropolyspora rectivirgula; alveolar epithelium; epithelial cells; hypersensitivity pneumoinitis; inflammation; lung defense
المشرفين على المادة: 0 (Hspa5 protein, mouse)
0 (HSPA5 protein, human)
0 (XBP1 protein, human)
0 (Xbp1 protein, mouse)
تواريخ الأحداث: Date Created: 20240510 Date Completed: 20240517 Latest Revision: 20240603
رمز التحديث: 20240603
مُعرف محوري في PubMed: PMC11107439
DOI: 10.1369/00221554241251915
PMID: 38725414
قاعدة البيانات: MEDLINE
الوصف
تدمد:1551-5044
DOI:10.1369/00221554241251915