دورية أكاديمية
Controversies and Conundrums in Cardiac Cachexia: Key Questions About Wasting in Patients With HFrEF.
| العنوان: | Controversies and Conundrums in Cardiac Cachexia: Key Questions About Wasting in Patients With HFrEF. |
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| المؤلفون: | Ilonze OJ; Division of Cardiovascular Medicine, Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Parsly Read-Button L; Frances Stern Nutrition Center, Tufts Medical Center, Boston, Massachusetts, USA., Cogswell R; Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota, USA., Hackman A; Heart and Vascular Center, Brigham and Women's Hospital, Boston, Massachusetts, USA., Breathett K; Division of Cardiovascular Medicine, Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Saltzman E; Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts, USA., Vest AR; CardioVascular Center, Tufts Medical Center, Boston, Massachusetts, USA. Electronic address: vesta2@ccf.org. |
| المصدر: | JACC. Heart failure [JACC Heart Fail] 2024 Apr 30. Date of Electronic Publication: 2024 Apr 30. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101598241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-1787 (Electronic) Linking ISSN: 22131779 NLM ISO Abbreviation: JACC Heart Fail Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier, [2013]- |
| مستخلص: | Cardiac cachexia is characterized by unintentional catabolic weight loss, decreased appetite, and inflammation and is common in patients with stage D (advanced) heart failure with reduced ejection fraction (HFrEF). Cardiac cachexia and related muscle-wasting syndromes are markers of, and a consequence of, the heart failure (HF) syndrome. Although many potential modalities for identifying cardiac cachexia exist, the optimal definition, diagnostic tools, and treatment options for cardiac cachexia remain unclear. Furthermore, it remains unclear whether attempts to reverse muscle wasting prior to advanced HF surgeries, such as left ventricular assist devices and heart transplantation, can improve outcomes. It is important that HF clinicians and dietitians are aware of the pathophysiology and mechanisms of muscle-wasting syndromes in patients with HF, to aid in the recognition and risk stratification of advanced HFrEF. Although the opportunities and rationale for attempting to address cardiac cachexia prior to advanced HF surgeries are uncertain, recent publications suggest that control of the neurohumoral syndrome of advanced HF may be important to permit the recovery of skeletal muscle mass. Competing Interests: Funding Support and Author Disclosures Dr Cogswell is a speaker for Abbott Laboratories. Dr Hackman has received speaker and consulting fees from Abbott; and has served on the speaking/advisory board for Medtronic. Dr Breathett has received research grant funding from the National Heart, Lung, and Blood Institute (grants K01HL142848, R01HL159216, R01HL16074), Health Resources and Services Administration of the U.S. Department of Health and Human Services, and Indiana University Clinical and Translational Sciences Institute. Dr Vest has received research grant funding from the National Heart, Lung, and Blood Institute (grant R01HL167113) and the National Center for Advancing Translational Sciences (grant RC2TR004377). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. (Copyright © 2024 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: advanced heart failure; cardiac cachexia; frailty; left ventricular assist device; sarcopenia; wasting syndrome |
| تواريخ الأحداث: | Date Created: 20240510 Latest Revision: 20240510 |
| رمز التحديث: | 20240510 |
| DOI: | 10.1016/j.jchf.2024.03.003 |
| PMID: | 38727650 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 2213-1787 |
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| DOI: | 10.1016/j.jchf.2024.03.003 |