دورية أكاديمية
Behavioral Assays Dissecting NMDA Receptor Function in Zebrafish.
| العنوان: | Behavioral Assays Dissecting NMDA Receptor Function in Zebrafish. |
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| المؤلفون: | Zoodsma JD; Graduate Program in Neuroscience, Stony Brook University, Stony Brook, NY, USA.; Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY, USA., Gomes CI; Graduate Program in Neuroscience, Stony Brook University, Stony Brook, NY, USA.; Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY, USA.; Department of Pediatrics, Stony Brook University, Stony Brook, NY, USA., Sirotkin HI; Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY, USA., Wollmuth LP; Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY, USA. lonnie.wollmuth@stonybrook.edu.; Department of Biochemistry & Cell Biology, Stony Brook University, Stony Brook, NY, USA. lonnie.wollmuth@stonybrook.edu.; Center for Nervous System Disorders, Stony Brook University, Stony Brook, NY, USA. lonnie.wollmuth@stonybrook.edu. |
| المصدر: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2799, pp. 243-255. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Totowa, NJ : Humana Press Original Publication: Clifton, N.J. : Humana Press, |
| مواضيع طبية MeSH: | Zebrafish*/metabolism , Receptors, N-Methyl-D-Aspartate*/metabolism , Behavior, Animal*/drug effects, Animals ; Larva/metabolism ; Brain/metabolism ; Brain/drug effects ; High-Throughput Screening Assays/methods |
| مستخلص: | Zebrafish are a powerful system to study brain development and to dissect the activity of complex circuits. One advantage is that they display complex behaviors, including prey capture, learning, responses to photic and acoustic stimuli, and social interaction (Dreosti et al., Front Neural Circuits 9:39, 2015; Bruckner et al., PLoS Biol 20:e3001838, 2022; Zoodsma et al., Mol Autism 13:38, 2022) that can be probed to assess brain function. Many of these behaviors are easily assayed at early larval stages, offering a noninvasive and high-throughput readout of nervous system function. Additionally, larval zebrafish readily uptake small molecules dissolved in water making them ideal for behavioral-based drug screens. Together, larval zebrafish and their behavioral repertoire offer a means to rapidly dissect brain circuitry and can serve as a template for high-throughput small molecule screens.NMDA receptor subunits are highly conserved in zebrafish compared to mammals (Zoodsma et al., Mol Autism 13:38, 2022; Cox et al., Dev Dyn 234:756-766, 2005; Zoodsma et al., J Neurosci 40:3631-3645, 2020). High amino acid and domain structure homology between humans and zebrafish underlie conserved functional similarities. Here we describe a set of behavioral assays that are useful to study the NMDA receptor activity in brain function. (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Learning; MK-801; Prey capture; Social behavior; Social interaction; Zebrafish |
| المشرفين على المادة: | 0 (Receptors, N-Methyl-D-Aspartate) |
| تواريخ الأحداث: | Date Created: 20240510 Date Completed: 20240510 Latest Revision: 20240702 |
| رمز التحديث: | 20240702 |
| DOI: | 10.1007/978-1-0716-3830-9_13 |
| PMID: | 38727911 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1940-6029 |
|---|---|
| DOI: | 10.1007/978-1-0716-3830-9_13 |