دورية أكاديمية

Features of Remyelination after Transplantation of Olfactory Ensheathing Cells with Neurotrophic Factors into Spinal Cord Cysts.

التفاصيل البيبلوغرافية
العنوان: Features of Remyelination after Transplantation of Olfactory Ensheathing Cells with Neurotrophic Factors into Spinal Cord Cysts.
المؤلفون: Stepanova OV; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.; E. I. Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia., Fursa GA; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia., Karsuntseva EK; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia. katya.karsunceva@gmail.com., Andretsova SS; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.; M. V. Lomonosov Moscow State University, Moscow, Russia., Chadin AV; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia., Voronova AD; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia., Shishkina VS; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia., Semkina AS; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.; Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia., Reshetov IV; University Clinical Hospital, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia., Chekhonin VP; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.; Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
المصدر: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Mar; Vol. 176 (5), pp. 666-671. Date of Electronic Publication: 2024 May 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
مواضيع طبية MeSH: Neurotrophin 3*/metabolism , Brain-Derived Neurotrophic Factor*/metabolism , Brain-Derived Neurotrophic Factor*/pharmacology , Remyelination*/physiology , Olfactory Bulb*/cytology, Animals ; Rats ; Humans ; Cell Proliferation ; Spinal Cord/metabolism ; Myelin Sheath/metabolism ; Myelin Sheath/physiology ; Cells, Cultured ; Cell Movement ; Cysts/pathology ; Female ; Central Nervous System Cysts/surgery ; Central Nervous System Cysts/pathology
مستخلص: This paper shows for the first time that co-transplantation of human olfactory ensheathing cells with neurotrophin-3 into spinal cord cysts is more effective for activation of remyelination than transplantation of cells with brain-derived neurotrophic factor and a combination of these two factors. The studied neurotrophic factors do not affect proliferation and migration of ensheathing cells in vitro. It can be concluded that the maximum improvement of motor function in rats receiving ensheathing cells with neurotrophin-3 is largely determined by activation of remyelination.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: brain-derived neurotrophic factor (BDNF); neurotrophin-3 (NT-3); olfactory ensheathing cells; remyelination; spinal cord cysts
تواريخ الأحداث: Date Created: 20240510 Date Completed: 20240517 Latest Revision: 20240517
رمز التحديث: 20240517
DOI: 10.1007/s10517-024-06088-x
PMID: 38727956
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-8221
DOI:10.1007/s10517-024-06088-x