دورية أكاديمية
Two Septin complexes mediate actin dynamics during cell wound repair.
| العنوان: | Two Septin complexes mediate actin dynamics during cell wound repair. |
|---|---|
| المؤلفون: | Stjepić V; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Nakamura M; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Hui J; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Parkhurst SM; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. Electronic address: susanp@fredhutch.org. |
| المصدر: | Cell reports [Cell Rep] 2024 May 28; Vol. 43 (5), pp. 114215. Date of Electronic Publication: 2024 May 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| مواضيع طبية MeSH: | Septins*/metabolism , Actins*/metabolism , Wound Healing* , Drosophila Proteins*/metabolism, Animals ; Actomyosin/metabolism ; Drosophila melanogaster/metabolism ; Contractile Proteins/metabolism ; Microfilament Proteins |
| مستخلص: | Cells have robust wound repair systems to prevent further damage or infection and to quickly restore cell cortex integrity when exposed to mechanical and chemical stress. Actomyosin ring formation and contraction at the wound edge are major events during closure of the plasma membrane and underlying cytoskeleton during cell wound repair. Here, we show that all five Drosophila Septins are required for efficient cell wound repair. Based on their different recruitment patterns and knockdown/mutant phenotypes, two distinct Septin complexes, Sep1/Sep2/Pnut and Sep4/Sep5/Pnut, are assembled to regulate actin ring assembly, contraction, and remodeling during the repair process. Intriguingly, we find that these two Septin complexes have different F-actin bending activities. In addition, we find that Anillin regulates the recruitment of only one of two Septin complexes upon wounding. Our results demonstrate that two functionally distinct Septin complexes work side by side to discretely regulate actomyosin ring dynamics during cell wound repair. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Update of: bioRxiv. 2023 Nov 16:2023.11.14.567084. doi: 10.1101/2023.11.14.567084. (PMID: 38014090) |
| References: | Curr Biol. 2021 May 24;31(10):R651-R666. (PMID: 34033796) J Cell Biol. 2019 Apr 1;218(4):1128-1137. (PMID: 30659102) Open Biol. 2018 Oct 3;8(10):. (PMID: 30282661) Mol Biol Cell. 2020 Oct 1;31(21):2289-2297. (PMID: 32991244) Curr Opin Cell Biol. 2018 Feb;50:27-34. (PMID: 29438904) J Cell Biol. 1995 Oct;131(1):165-78. (PMID: 7559773) PLoS Genet. 2020 Dec 11;16(12):e1009186. (PMID: 33306674) Nat Cell Biol. 2006 Apr;8(4):367-76. (PMID: 16518391) J Mol Biol. 2021 Jul 23;433(15):167096. (PMID: 34116125) FEBS Lett. 2020 Apr;594(8):1237-1247. (PMID: 31853940) Mol Biol Cell. 2014 May;25(10):1594-607. (PMID: 24648497) J Cell Sci. 2018 Jun 28;131(12):. (PMID: 29777035) Front Cell Dev Biol. 2017 May 03;5:42. (PMID: 28516085) Nat Rev Mol Cell Biol. 2012 Feb 08;13(3):183-94. (PMID: 22314400) J Cell Biol. 2011 May 2;193(3):455-64. (PMID: 21518790) Dev Cell. 2011 Apr 19;20(4):540-9. (PMID: 21497764) Curr Opin Cell Biol. 2007 Feb;19(1):95-100. (PMID: 17174083) Dev Cell. 2023 Aug 7;58(15):1399-1413.e5. (PMID: 37329886) Cell Discov. 2021 Jan 19;7(1):4. (PMID: 33462191) J Cell Biol. 2020 Sep 7;219(9):. (PMID: 32673395) J Int Med Res. 2009 Sep-Oct;37(5):1528-42. (PMID: 19930861) Dev Cell. 2013 Feb 11;24(3):227-41. (PMID: 23410938) Biol Chem. 2014 Feb;395(2):123-41. (PMID: 24114910) Dev Cell. 2015 May 26;33(4):413-26. (PMID: 25959226) Elife. 2019 Jan 23;8:. (PMID: 30672734) Genome. 2013 Dec;56(12):753-8. (PMID: 24433211) PLoS One. 2014 Mar 24;9(3):e92819. (PMID: 24664283) Mech Dev. 1998 Nov;78(1-2):113-8. (PMID: 9858703) Methods Cell Biol. 2016;136:199-220. (PMID: 27473911) Semin Cell Dev Biol. 2010 Dec;21(9):881-91. (PMID: 20732437) Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2595-2602. (PMID: 30692249) Diabetes. 2011 Nov;60(11):3034-43. (PMID: 21940783) Mol Biol Cell. 2023 Mar 1;34(3):ar15. (PMID: 36598808) J Cell Biol. 2000 Aug 7;150(3):539-52. (PMID: 10931866) Nat Cell Biol. 2014 Apr;16(4):322-34. (PMID: 24633326) Trends Cell Biol. 2021 Dec;31(12):979-993. (PMID: 34253430) Dev Cell. 2018 Jul 16;46(2):204-218.e7. (PMID: 30016622) Dev Cell. 2002 Dec;3(6):791-802. (PMID: 12479805) J Cell Sci. 2021 Aug 1;134(15):. (PMID: 34350965) Cytoskeleton (Hoboken). 2019 Jan;76(1):7-14. (PMID: 29979831) Nat Commun. 2022 Nov 16;13(1):7008. (PMID: 36385016) J Cell Biol. 2005 Jan 31;168(3):429-39. (PMID: 15684032) Mol Biol Cell. 2021 Feb 1;32(3):289-300. (PMID: 33263440) Annu Rev Cell Dev Biol. 2011;27:237-63. (PMID: 21721944) Front Cell Dev Biol. 2023 Feb 17;11:1112319. (PMID: 36875762) J Cell Sci. 2018 Jan 11;131(1):. (PMID: 29326311) Curr Opin Cell Biol. 2021 Feb;68:105-112. (PMID: 33188984) Am J Pathol. 2021 Jan;191(1):40-51. (PMID: 33039354) Nat Rev Mol Cell Biol. 2008 Jun;9(6):478-89. (PMID: 18478031) Nat Methods. 2012 Jun 28;9(7):676-82. (PMID: 22743772) BMC Biol. 2021 Apr 13;19(1):71. (PMID: 33849525) J Cell Biol. 2023 Mar 6;222(3):. (PMID: 36562751) Fac Rev. 2023 Mar 21;12:7. (PMID: 37081903) Curr Biol. 2008 Jan 8;18(1):30-6. (PMID: 18158243) Biol Chem. 2013 Feb;394(2):281-90. (PMID: 23087102) J Biol Chem. 2015 Jul 10;290(28):17173-80. (PMID: 25957401) Physiol Rev. 2015 Oct;95(4):1205-40. (PMID: 26336031) Cells. 2022 Sep 06;11(18):. (PMID: 36139352) Curr Biol. 2012 Jan 10;22(1):64-9. (PMID: 22197245) Bioessays. 2020 Oct;42(10):e2000055. (PMID: 32735042) Mol Biol Cell. 2010 May 1;21(9):1482-93. (PMID: 20237160) Curr Biol. 2018 Apr 23;28(8):R392-R397. (PMID: 29689221) J Cell Biol. 1998 Nov 2;143(3):737-49. (PMID: 9813094) Front Cell Dev Biol. 2017 Feb 07;5:3. (PMID: 28224124) J Mol Biol. 2017 Mar 10;429(5):715-731. (PMID: 28147230) Cell Rep. 2022 Apr 19;39(3):110722. (PMID: 35443188) Cytoskeleton (Hoboken). 2010 Aug;67(8):477-86. (PMID: 20540086) Curr Biol. 2014 Jan 20;24(2):144-155. (PMID: 24388847) J Cell Biol. 2013 Nov 11;203(3):487-504. (PMID: 24217622) J Cell Sci. 2011 Dec 15;124(Pt 24):4141-6. (PMID: 22247190) iScience. 2023 May 19;26(6):106903. (PMID: 37378349) G3 (Bethesda). 2016 Jul 07;6(7):1947-57. (PMID: 27172205) J Biochem. 2003 Oct;134(4):491-6. (PMID: 14607974) Cytoskeleton (Hoboken). 2019 Sep;76(9-10):449-456. (PMID: 31614074) J Cell Sci. 2018 Apr 13;131(8):. (PMID: 29549166) Nat Commun. 2021 Jul 28;12(1):4595. (PMID: 34321459) Biophys J. 2021 Sep 21;120(18):4029-4040. (PMID: 34390686) Development. 1993 Jun;118(2):401-15. (PMID: 8223268) J Cell Biol. 2000 Nov 13;151(4):905-18. (PMID: 11076973) J Cell Biol. 2008 Jan 28;180(2):285-94. (PMID: 18209105) Mol Biol Cell. 2000 Sep;11(9):3123-35. (PMID: 10982405) Front Cell Dev Biol. 2021 Nov 19;9:765085. (PMID: 34869357) J Cell Biol. 2017 Dec 4;216(12):3959-3969. (PMID: 28923977) Nature. 2015 Aug 20;524(7565):351-5. (PMID: 26214737) Curr Biol. 1999 Jun 3;9(11):579-87. (PMID: 10359696) J Cell Biol. 2000 Apr 17;149(2):471-90. (PMID: 10769037) Development. 2005 Jun;132(12):2837-48. (PMID: 15930113) Development. 2009 Aug;136(16):2849-60. (PMID: 19633175) J Math Biol. 2022 Jul 4;85(1):4. (PMID: 35788426) Curr Biol. 2016 Mar 7;26(5):616-26. (PMID: 26898468) J Cell Biol. 1996 May;133(3):605-16. (PMID: 8636235) Development. 2005 Jun;132(12):2849-60. (PMID: 15930114) Mol Neurodegener. 2015 Apr 03;10:16. (PMID: 25888325) Curr Biol. 2002 Oct 29;12(21):1858-63. (PMID: 12419187) Annu Rev Microbiol. 2015;69:487-503. (PMID: 26488282) |
| معلومات مُعتمدة: | P30 CA015704 United States CA NCI NIH HHS; R01 GM111635 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: Anillin; CP: Cell biology; Drosophila; Septins; actin bending; actin bundling; cell wound repair; cytoskeleton |
| المشرفين على المادة: | EC 3.6.1.- (Septins) 0 (Actins) 0 (Drosophila Proteins) 9013-26-7 (Actomyosin) 0 (pnut protein, Drosophila) 0 (Contractile Proteins) 0 (Microfilament Proteins) |
| تواريخ الأحداث: | Date Created: 20240510 Date Completed: 20240531 Latest Revision: 20240729 |
| رمز التحديث: | 20240729 |
| مُعرف محوري في PubMed: | PMC11203717 |
| DOI: | 10.1016/j.celrep.2024.114215 |
| PMID: | 38728140 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2211-1247 |
|---|---|
| DOI: | 10.1016/j.celrep.2024.114215 |