دورية أكاديمية
Streptococcus pneumoniae among the children of Aden, Yemen: a cross-sectional report of post-pneumococcal conjugate vaccine.
| العنوان: | Streptococcus pneumoniae among the children of Aden, Yemen: a cross-sectional report of post-pneumococcal conjugate vaccine. |
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| المؤلفون: | Matran YM; Department of Para-Clinic, Unit of Clinical Microbiology, Faculty of Medicine and Health Sciences, University of Aden, Yemen., Al-Haddad AM; Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Hadhramout University, Yemen., Kour A; School of Allied Medical Sciences, Lovely Professional University, India., Al-Shehabi H; Department of HIV and Other Retroviruses, Robert Koch Institute, Germany., Sharma S; Department of Sponsored Research, Lovely Professional University, India., Suttee A; Department of Pharmacognosy, Lovely Professional University, India., Sharma S; School of Allied Medical Sciences, Lovely Professional University, India. |
| المصدر: | Journal of infection in developing countries [J Infect Dev Ctries] 2024 Apr 30; Vol. 18 (4), pp. 579-586. Date of Electronic Publication: 2024 Apr 30. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Open Learning on Enteric Pathogens Country of Publication: Italy NLM ID: 101305410 Publication Model: Electronic Cited Medium: Internet ISSN: 1972-2680 (Electronic) Linking ISSN: 19722680 NLM ISO Abbreviation: J Infect Dev Ctries Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Italy?] : Open Learning on Enteric Pathogens |
| مواضيع طبية MeSH: | Streptococcus pneumoniae*/drug effects , Streptococcus pneumoniae*/isolation & purification , Streptococcus pneumoniae*/classification , Pneumococcal Infections*/epidemiology , Pneumococcal Infections*/prevention & control , Pneumococcal Infections*/microbiology , Pneumococcal Vaccines*/administration & dosage , Carrier State*/epidemiology , Carrier State*/microbiology , Nasopharynx*/microbiology , Serogroup* , Vaccines, Conjugate*/administration & dosage, Humans ; Child ; Child, Preschool ; Cross-Sectional Studies ; Yemen/epidemiology ; Female ; Male ; Adolescent ; Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests ; Serotyping |
| مستخلص: | Introduction: Streptococcus pneumoniae cause a significant global health challenge. We aimed to determine nasopharyngeal carriage, serotypes distribution, and antimicrobial profile of pneumococci among the children of Aden. Methodology: A total of 385 children, aged 2-17 years, were included. Asymptomatic samples were randomly collected from children in selected schools and vaccination centers. Symptomatic samples were obtained from selected pediatric clinics. The nasopharyngeal swabs were tested for pneumococci using culture and real time polymerase chain reaction (RT-PCR). Serotyping was done with a pneumotest-latex kit and antimicrobial susceptibility was tested by disc diffusion and Epsilometer test. Results: The total pneumococcal carriage was 44.4% and 57.1% by culture and RT-PCR, respectively. There was a statistically significant association between carriage rate and living in single room (OR = 7.9; p = 0.00001), sharing a sleeping space (OR = 15.1; p = 0.00001), and low monthly income (OR = 2.02; p = 0.007). The common serotypes were 19, 1, 4, 5, 2, and 23. The proportion of non-pneumococcal conjugate vaccine (non-PCV13) serotypes was 24%. Pneumococci were resistant to penicillin (96.5%), cefepime (15.8%), ceftriaxone (16.4%), and amoxicillin-clavulanate (0%). Erythromycin, azithromycin, and doxycycline had resistance rates of 48%, 31%, and 53.3%, respectively. Conclusions: A high pneumococcal carriage rate was observed in Yemeni children, particularly in low-income households and shared living conditions. There was significant penicillin resistance at meningitis breakpoint. Furthermore, non-PCV13 serotypes were gradually replacing PCV13 serotypes. The findings underscore the urgent need for enhanced surveillance and stewardship to improve vaccination and antibiotic policies in Yemen. Competing Interests: No Conflict of Interest is declared (Copyright (c) 2024 Yasser M Matran, Ahmed M Al-Haddad, Avleen Kour, Hussein Al-Shehabi, Sarika Sharma, Ashish Suttee, Sandeep Sharma.) |
| فهرسة مساهمة: | Keywords: Yemen; antimicrobial; children; pneumococci; serotypes; vaccine |
| المشرفين على المادة: | 0 (Pneumococcal Vaccines) 0 (Vaccines, Conjugate) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20240510 Date Completed: 20240510 Latest Revision: 20240510 |
| رمز التحديث: | 20240511 |
| DOI: | 10.3855/jidc.18935 |
| PMID: | 38728636 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1972-2680 |
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| DOI: | 10.3855/jidc.18935 |