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Anti-Photodamage Effect of Agaricus blazei Murill Polysaccharide on UVB-Damaged HaCaT Cells.

التفاصيل البيبلوغرافية
العنوان: Anti-Photodamage Effect of Agaricus blazei Murill Polysaccharide on UVB-Damaged HaCaT Cells.
المؤلفون: Cheng W; School of Light Industry Science and Engineering, Beijing Technology & Business University, Beijing 100048, China.; Beijing Key Lab of Plant Resource Research and Development, Beijing 100048, China.; Institute of Cosmetic Regulatory Science, Beijing 100048, China., Di F; School of Light Industry Science and Engineering, Beijing Technology & Business University, Beijing 100048, China.; Beijing Key Lab of Plant Resource Research and Development, Beijing 100048, China.; Institute of Cosmetic Regulatory Science, Beijing 100048, China., Li L; School of Light Industry Science and Engineering, Beijing Technology & Business University, Beijing 100048, China.; Beijing Key Lab of Plant Resource Research and Development, Beijing 100048, China.; Institute of Cosmetic Regulatory Science, Beijing 100048, China., Pu C; School of Light Industry Science and Engineering, Beijing Technology & Business University, Beijing 100048, China.; Beijing Key Lab of Plant Resource Research and Development, Beijing 100048, China.; Institute of Cosmetic Regulatory Science, Beijing 100048, China., Wang C; School of Light Industry Science and Engineering, Beijing Technology & Business University, Beijing 100048, China.; Beijing Key Lab of Plant Resource Research and Development, Beijing 100048, China.; Institute of Cosmetic Regulatory Science, Beijing 100048, China., Zhang J; School of Light Industry Science and Engineering, Beijing Technology & Business University, Beijing 100048, China.; Beijing Key Lab of Plant Resource Research and Development, Beijing 100048, China.; Institute of Cosmetic Regulatory Science, Beijing 100048, China.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 25; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Agaricus*/chemistry , Ultraviolet Rays*/adverse effects , HaCaT Cells* , Filaggrin Proteins* , Cell Proliferation*/drug effects, Humans ; Membrane Potential, Mitochondrial/drug effects ; Fungal Polysaccharides/pharmacology ; Fungal Polysaccharides/chemistry ; Polysaccharides/pharmacology ; Polysaccharides/chemistry ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Keratinocytes/radiation effects ; Cytokines/metabolism
مستخلص: UVB radiation is known to induce photodamage to the skin, disrupt the skin barrier, elicit cutaneous inflammation, and accelerate the aging process. Agaricus blazei Murill (ABM) is an edible medicinal and nutritional fungus. One of its constituents, Agaricus blazei Murill polysaccharide (ABP), has been reported to exhibit antioxidant, anti-inflammatory, anti-tumor, and immunomodulatory effects, which suggests potential effects that protect against photodamage. In this study, a UVB-induced photodamage HaCaT model was established to investigate the potential reparative effects of ABP and its two constituents (A1 and A2). Firstly, two purified polysaccharides, A1 and A2, were obtained by DEAE-52 cellulose column chromatography, and their physical properties and chemical structures were studied. A1 and A2 exhibited a network-like microstructure, with molecular weights of 1.5 × 10 4 Da and 6.5 × 10 4 Da, respectively. The effects of A1 and A2 on cell proliferation, the mitochondrial membrane potential, and inflammatory factors were also explored. The results show that A1 and A2 significantly promoted cell proliferation, enhanced the mitochondrial membrane potential, suppressed the expression of inflammatory factors interleukin-1β (IL-1β), interleukin-8 (IL-8), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α), and increased the relative content of filaggrin (FLG) and aquaporin-3 (AQP3). The down-regulated JAK-STAT signaling pathway was found to play a role in the response to photodamage. These findings underscore the potential of ABP to ameliorate UVB-induced skin damage.
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فهرسة مساهمة: Keywords: Agaricus blazei Murill polysaccharide (ABP); UVB-damaged model; anti-photodamage; antioxidation; inflammation; structural characterization
المشرفين على المادة: 0 (Filaggrin Proteins)
0 (FLG protein, human)
0 (Fungal Polysaccharides)
0 (Polysaccharides)
0 (Cytokines)
تواريخ الأحداث: Date Created: 20240511 Date Completed: 20240511 Latest Revision: 20240513
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC11083510
DOI: 10.3390/ijms25094676
PMID: 38731895
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25094676