دورية أكاديمية
أعرض في EDS

The Intricacies of Renal Phosphate Reabsorption-An Overview.

التفاصيل البيبلوغرافية
العنوان: The Intricacies of Renal Phosphate Reabsorption-An Overview.
المؤلفون: Walker V; Department of Clinical Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton S016 6YD, UK.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 25; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 25.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Phosphates*/metabolism, Humans ; Animals ; Renal Reabsorption ; Kidney/metabolism ; Kidney Tubules, Proximal/metabolism
مستخلص: To maintain an optimal body content of phosphorus throughout postnatal life, variable phosphate absorption from food must be finely matched with urinary excretion. This amazing feat is accomplished through synchronised phosphate transport by myriads of ciliated cells lining the renal proximal tubules. These respond in real time to changes in phosphate and composition of the renal filtrate and to hormonal instructions. How they do this has stimulated decades of research. New analytical techniques, coupled with incredible advances in computer technology, have opened new avenues for investigation at a sub-cellular level. There has been a surge of research into different aspects of the process. These have verified long-held beliefs and are also dramatically extending our vision of the intense, integrated, intracellular activity which mediates phosphate absorption. Already, some have indicated new approaches for pharmacological intervention to regulate phosphate in common conditions, including chronic renal failure and osteoporosis, as well as rare inherited biochemical disorders. It is a rapidly evolving field. The aim here is to provide an overview of our current knowledge, to show where it is leading, and where there are uncertainties. Hopefully, this will raise questions and stimulate new ideas for further research.
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فهرسة مساهمة: Keywords: Na+/H+ exchange regulatory cofactor-1 (NHERF1); NaPi-2a sodium-dependent phosphate transporter-2a (NaPi-2a); allosteric regulation; fibroblast growth factor 23 (FGF23); hyperphosphatemia; hypophosphatemia; kidney stones; parathyroid hormone/parathyroid hormone related protein receptor (PTH/PTHrP receptor); regulator of G protein signalling 14 (RGS14); tumour-induced osteomalacia (TIO)
المشرفين على المادة: 0 (Phosphates)
تواريخ الأحداث: Date Created: 20240511 Date Completed: 20240511 Latest Revision: 20240513
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC11083860
DOI: 10.3390/ijms25094684
PMID: 38731904
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25094684