دورية أكاديمية
أعرض في EDS

Green Synthesized Chitosan Nanoparticles for Controlling Multidrug-Resistant mecA- and blaZ -Positive Staphylococcus aureus and aadA1 -Positive Escherichia coli .

التفاصيل البيبلوغرافية
العنوان: Green Synthesized Chitosan Nanoparticles for Controlling Multidrug-Resistant mecA- and blaZ -Positive Staphylococcus aureus and aadA1 -Positive Escherichia coli .
المؤلفون: Rahman A; Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh., Kafi MA; Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh., Beak G; Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 04107, Republic of Korea., Saha SK; Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh., Roy KJ; Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh., Habib A; Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh., Faruqe T; Experimental Physics Division, Atomic Energy Centre, Dhaka 1000, Bangladesh., Siddique MP; Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh., Islam MS; Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh., Hossain KS; Department of Physics, University of Dhaka, Dhaka 1000, Bangladesh., Choi JW; Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 04107, Republic of Korea.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 26; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Chitosan*/pharmacology , Chitosan*/chemistry , Drug Resistance, Multiple, Bacterial*/drug effects , Escherichia coli*/drug effects , Escherichia coli*/genetics , Nanoparticles*/chemistry , Staphylococcus aureus*/drug effects, Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Green Chemistry Technology ; Microbial Sensitivity Tests ; Penicillin-Binding Proteins/genetics ; Penicillin-Binding Proteins/metabolism ; Penicillin-Binding Proteins/antagonists & inhibitors
مستخلص: Antimicrobial resistance has recently been considered an emerging catastrophe globally. The public health and environmental threats were aggravated by the injudicious use of antibiotics in animal farming, aquaculture, and croup fields, etc. Consequently, failure of antibiotic therapies is common because of the emergence of multidrug-resistant (MDR) bacteria in the environment. Thus, the reduction in antibiotic spillage in the environment could be an important step for overcoming this situation. Bear in mind, this research was focused on the green synthesis of chitosan nanoparticles (ChiNPs) using Citrus lemon (Assam lemon) extract as a cross-linker and application in controlling MDR bacteria to reduce the antibiotic spillage in that sector. For evaluating antibacterial activity, Staphylococcus aureus and Escherichia coli were isolated from environmental specimens, and their multidrug-resistant pattern were identified both phenotypically by disk diffusion and genotypically by detecting methicillin- ( mecA ), penicillin- ( blaZ ), and streptomycin ( aadA1 )-resistance encoding genes. The inhibitory zone's diameter was employed as a parameter for determining the antibacterial effect against MDR bacteria revealing 30 ± 0.4 mm, 34 ± 0.2 mm, and 36 ± 0.8 mm zones of inhibition against methicillin- ( mecA ) and penicillin ( blaZ )-resistant S. aureus , and streptomycin ( aadA1 )-resistant E. coli , respectively. The minimum inhibitory concentration at 0.31 mg/mL and minimum bactericidal concentration at 0.62 mg/mL of yielded ChiNPs were used as the broad-spectrum application against MDR bacteria. Finally, the biocompatibility of ChiNPs was confirmed by showing a negligible decrease in BHK-21 cell viability at doses less than 2 MIC, suggesting their potential for future application in antibiotic-free farming practices.
Competing Interests: The authors declare no conflicts of interest.
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معلومات مُعتمدة: TF122-L/23 Biogenic extraction of nanoparticle from shrimp waste as antimicrobial in broiler farmin; SRG-224547 Development of chitosan bio-platform with Human Dermal Fibroblast cell adhesion and prolif-eration for real-time wound healing and monitoring; 2019R1A2C3002300 the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT); NRF-2022M3H4A1A01005271 the National R&D Program through the NRF funded by the Ministry of Science and ICT; RS-2023-00259341 the GRDC Cooperative Hub through the National Research Foundation of Korea funded by the Ministry of Science and ICT
فهرسة مساهمة: Keywords: MBC; MDR bacteria; MIC; antimicrobial; biocompatibility; chitosan nanoparticles; green synthesis
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Bacterial Proteins)
9012-76-4 (Chitosan)
0 (mecA protein, Staphylococcus aureus)
0 (Penicillin-Binding Proteins)
تواريخ الأحداث: Date Created: 20240511 Date Completed: 20240511 Latest Revision: 20240610
رمز التحديث: 20240610
مُعرف محوري في PubMed: PMC11083359
DOI: 10.3390/ijms25094746
PMID: 38731965
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25094746