دورية أكاديمية
أعرض في EDS

The Usefulness of Vitamin K-Dependent Proteins in the Diagnosis of Colorectal Carcinoma.

التفاصيل البيبلوغرافية
العنوان: The Usefulness of Vitamin K-Dependent Proteins in the Diagnosis of Colorectal Carcinoma.
المؤلفون: Perné MG; 4th Department-Internal Medicine, 4th Medical Discipline, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Republicii Street, Nr. 18, 400015 Cluj-Napoca, Romania., Sitar-Tăut AV; 4th Department-Internal Medicine, 4th Medical Discipline, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Republicii Street, Nr. 18, 400015 Cluj-Napoca, Romania., Orășan OH; 4th Department-Internal Medicine, 4th Medical Discipline, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Republicii Street, Nr. 18, 400015 Cluj-Napoca, Romania., Negrean V; 4th Department-Internal Medicine, 4th Medical Discipline, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Republicii Street, Nr. 18, 400015 Cluj-Napoca, Romania., Vlad CV; 4th Department-Internal Medicine, 4th Medical Discipline, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Republicii Street, Nr. 18, 400015 Cluj-Napoca, Romania., Alexescu TG; 4th Department-Internal Medicine, 4th Medical Discipline, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Republicii Street, Nr. 18, 400015 Cluj-Napoca, Romania., Milaciu MV; 4th Department-Internal Medicine, 4th Medical Discipline, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Republicii Street, Nr. 18, 400015 Cluj-Napoca, Romania., Ciumărnean L; 4th Department-Internal Medicine, 4th Medical Discipline, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Republicii Street, Nr. 18, 400015 Cluj-Napoca, Romania., Togănel RD; 6th Department-Surgery, 4th Surgery Discipline, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Republicii Street, Nr. 18, 400015 Cluj-Napoca, Romania., Petre GE; 6th Department-Surgery, 4th Surgery Discipline, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Republicii Street, Nr. 18, 400015 Cluj-Napoca, Romania., Șimon I; 6th Department-Surgery, 4th Surgery Discipline, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Republicii Street, Nr. 18, 400015 Cluj-Napoca, Romania., Crăciun A; 2nd Department-Molecular Sciences, Discipline of Medical Biochemistry, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Pasteur Street, Nr. 6, 400349 Cluj-Napoca, Romania.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 May 03; Vol. 25 (9). Date of Electronic Publication: 2024 May 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Biomarkers, Tumor*/blood , Colorectal Neoplasms*/blood , Colorectal Neoplasms*/diagnosis , Colorectal Neoplasms*/pathology, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Biomarkers ; CA-19-9 Antigen/blood ; Calcium-Binding Proteins/blood ; Carcinoembryonic Antigen/blood ; Extracellular Matrix Proteins/blood ; Liver Neoplasms/blood ; Liver Neoplasms/diagnosis ; Liver Neoplasms/secondary ; Matrix Gla Protein ; Protein Precursors/blood ; Prothrombin/metabolism ; ROC Curve ; Vitamin K/blood
مستخلص: Colorectal cancer (CRC) is one of the most common neoplasms in developed countries, with increasing incidence and mortality, even in young people. A variety of serum markers have been associated with CRC (CEA, CA 19-9), but neither should be used as a screening tool for the diagnosis or evolution staging of CRC. The sensitivity and specificity of these markers are not as good as is required, so new ones need to be found. Matrix Gla protein and PIVKA II are involved in carcinogenesis, but few studies have evaluated their usefulness in predicting the presence and severity of CRC. Two hundred patients were divided into three groups: 80 patients were included in the control group; 80 with CRC and without hepatic metastasis were included in Group 1; 40 patients with CRC and hepatic metastasis were included in Group 2. Vitamin K-dependent proteins (VKDPs) levels in plasma were determined. Patients with CRC without methastasis (Group 1) and CRC patients with methastasis (Group 2) presented significantly higher values of CEA, CA 19-9, PIVKA II (310.05 ± 38.22 vs. 430.13 ± 122.13 vs. 20.23 ± 10.90), and ucMGP (14,300.00 ± 2387.02 vs. 13,410.52 ± 2243.16 vs. 1780.31 ± 864.70) compared to control group (Group 0). Interestingly, Group 1 presented the greatest PIVKA II values. Out of all the markers, significant differences between the histological subgroups were found only for ucMGP, but only in non-metastatic CRC. Studying the discrimination capacity between the patients with CRC vs. those without, no significant differences were found between the classical tumor markers and the VKDP AUROC curves (PIVKA II and ucMGP AUROCs = 1). For the metastatic stage, the sensitivity and specificity of the VKDPs were lower in comparison with those of CA 19-9 and CEA, respectively (PIVKA II AUROC = 0.789, ucMGP AUROC = 0.608). The serum levels of these VKDPs are significantly altered in patients with colorectal carcinoma; it is possible to find additional value of these in the early stages of the disease.
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معلومات مُعتمدة: PCD 2462/1/17 ianuarie 2020 Iuliu Hațieganu University of Medicine and Pharmacy
فهرسة مساهمة: Keywords: CA19-9; CEA; PIVKA II; colorectal cancer; diagnosis; ucMGP; vitamin K
المشرفين على المادة: 53230-14-1 (acarboxyprothrombin)
0 (Biomarkers)
0 (Biomarkers, Tumor)
0 (CA-19-9 Antigen)
0 (Calcium-Binding Proteins)
0 (Carcinoembryonic Antigen)
0 (Extracellular Matrix Proteins)
0 (Matrix Gla Protein)
0 (Protein Precursors)
9001-26-7 (Prothrombin)
12001-79-5 (Vitamin K)
تواريخ الأحداث: Date Created: 20240511 Date Completed: 20240511 Latest Revision: 20240607
رمز التحديث: 20240607
مُعرف محوري في PubMed: PMC11084444
DOI: 10.3390/ijms25094997
PMID: 38732222
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25094997