دورية أكاديمية
أعرض في EDS

Injectable Self-Oxygenating Cardio-Protective and Tissue Adhesive Silk-Based Hydrogel for Alleviating Ischemia After Mi Injury.

التفاصيل البيبلوغرافية
العنوان: Injectable Self-Oxygenating Cardio-Protective and Tissue Adhesive Silk-Based Hydrogel for Alleviating Ischemia After Mi Injury.
المؤلفون: Hassan S; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States.; Department of Biological Sciences, Khalifa University, Shakhbout Bin Sultan St, Abu Dhabi, 127788, United Arab Emirates.; Biotechnology Center (BTC), Khalifa University, Shakhbout Bin Sultan St, Abu Dhabi, 127788, United Arab Emirates., Rezaei Z; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States.; Department of Chemical Engineering, Sharif University of Technology, Tehran, 1365-11155, Iran., Luna E; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States., Yilmaz-Aykut D; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States.; Department of Chemical Engineering, Faculty of Engineering, Istanbul University-Cerrahpaşa, Istanbul, 34320, Turkey., Lee MC; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States.; Biomedical Research Division, Medicinal Materials Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea., Perea AM; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States.; School of Science and Engineering, Technologico de Monterrey, Monterrey, Mexico., Jamaiyar A; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Bassous N; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States., Hirano M; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States.; Future Vehicle Research Department, Toyota Research Institute North America, Toyota Motor North America, Inc., 1555 Woodridge Ave., Ann Arbor, MI, 48105, USA., Tourk FM; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States.; Department of Mechanical Engineering, Northeastern University, Boston, MA, 02115, USA., Choi C; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States., Becker M; Department of BioEngineering Technologies, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands., Yazdi I; School of Arts and Sciences, Regis College, 235 Wellesley Street, Weston, MA, 02493, USA., Fan K; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States.; School of Automation, Hangzhou Dianzi, Hangzhou, Zhejiang, 310018, China., Avila-Ramirez AE; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States.; Division of Biological and Environmental Science Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia., Ge D; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States., Abdi R; Transplantation Research Center, Renal Division, Brigham and Women's Hospital / Harvard Medical School, Boston, MA, 02115, USA., Fisch S; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Leijten J; Department of BioEngineering Technologies, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands., Feinberg MW; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Mandal BB; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.; Center for nanotechnology, Indian Institute of Technology Guwahati (IITG), Guwahati, Assam, 781039, India.; Jyoti and Bhupat Mehta School of health Sciences and Technology, Indian Institute of Technology Guwahati (IITG), Guwahati, Assam, 781039, India., Liao R; School of Medicine, Stanford University, Stanford, CA, 94305-5101, USA.; Stanford Amyloid Center, Stanford University, Stanford, CA, 94305-5101, USA., Shin SR; Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States.
المصدر: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Aug; Vol. 20 (32), pp. e2312261. Date of Electronic Publication: 2024 May 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101235338 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-6829 (Electronic) Linking ISSN: 16136810 NLM ISO Abbreviation: Small Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH, c2005-
مواضيع طبية MeSH: Myocardial Infarction*/pathology , Myocardial Infarction*/drug therapy , Silk*/chemistry , Hydrogels*/chemistry , Oxygen*/chemistry, Animals ; Tissue Adhesives/chemistry ; Tissue Adhesives/pharmacology ; Injections ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/administration & dosage ; Cardiotonic Agents/chemistry ; Chemokine CXCL12/administration & dosage ; Chemokine CXCL12/pharmacology ; Chemokine CXCL12/metabolism ; Myocytes, Cardiac/drug effects ; Rats
مستخلص: Myocardial infarction (MI) is a significant cardiovascular disease that restricts blood flow, resulting in massive cell death and leading to stiff and noncontractile fibrotic scar tissue formation. Recently, sustained oxygen release in the MI area has shown regeneration ability; however, improving its therapeutic efficiency for regenerative medicine remains challenging. Here, a combinatorial strategy for cardiac repair by developing cardioprotective and oxygenating hybrid hydrogels that locally sustain the release of stromal cell-derived factor-1 alpha (SDF) and oxygen for simultaneous activation of neovascularization at the infarct area is presented. A sustained release of oxygen and SDF from injectable, mechanically robust, and tissue-adhesive silk-based hybrid hydrogels is achieved. Enhanced endothelialization under normoxia and anoxia is observed. Furthermore, there is a marked improvement in vascularization that leads to an increment in cardiomyocyte survival by ≈30% and a reduction of the fibrotic scar formation in an MI animal rodent model. Improved left ventricular systolic and diastolic functions by ≈10% and 20%, respectively, with a ≈25% higher ejection fraction on day 7 are also observed. Therefore, local delivery of therapeutic oxygenating and cardioprotective hydrogels demonstrates beneficial effects on cardiac functional recovery for reparative therapy.
(© 2024 Wiley‐VCH GmbH.)
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معلومات مُعتمدة: NRF-2021R1A6A14039720 Basic Science Research Program through the National Research Foundation of Korea; R01 AR074234 United States AR NIAMS NIH HHS; 8474000442 Khalifa University; 19IPLOI34660079 American Heart Association; 19IPLOI34660079 United States AHA American Heart Association-American Stroke Association; R01AR074234 United States NH NIH HHS
فهرسة مساهمة: Keywords: myocardial infarction; oxygenating microparticles; silk hydrogel; stromal differentiation factor; vascularization
المشرفين على المادة: 0 (Silk)
0 (Hydrogels)
S88TT14065 (Oxygen)
0 (Tissue Adhesives)
0 (Cardiotonic Agents)
0 (Chemokine CXCL12)
تواريخ الأحداث: Date Created: 20240511 Date Completed: 20240808 Latest Revision: 20240810
رمز التحديث: 20240812
مُعرف محوري في PubMed: PMC11309903
DOI: 10.1002/smll.202312261
PMID: 38733225
قاعدة البيانات: MEDLINE
الوصف
تدمد:1613-6829
DOI:10.1002/smll.202312261