دورية أكاديمية
Cough Response to High-Dose Inhaled Corticosteroids in Patients with Chronic Cough and Fractional Exhaled Nitric Oxide Levels ≥ 25 ppb: A Prospective Study.
| العنوان: | Cough Response to High-Dose Inhaled Corticosteroids in Patients with Chronic Cough and Fractional Exhaled Nitric Oxide Levels ≥ 25 ppb: A Prospective Study. |
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| المؤلفون: | Lee JH; Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea., Kang SY; Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea., Yu I; Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea., Park KE; University of Ulsan College of Medicine, Seoul, Korea., Oh JY; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea., Lee JH; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea., Park SY; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea., Kim MH; Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea., Jo EJ; Department of Internal Medicine, School of Medicine, Pusan National University, Busan, Korea., Moon JY; Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea., Kim SH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea., Kim SH; Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea., Lee BJ; Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Song WJ; University of Ulsan College of Medicine, Seoul, Korea. swj0126@amc.seoul.kr.; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea. swj0126@amc.seoul.kr. |
| مؤلفون مشاركون: | Korean Academy of Asthma Allergy, Clinical Immunology Working Group on Chronic Cough |
| المصدر: | Lung [Lung] 2024 Jun; Vol. 202 (3), pp. 275-280. Date of Electronic Publication: 2024 May 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: United States NLM ID: 7701875 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1750 (Electronic) Linking ISSN: 03412040 NLM ISO Abbreviation: Lung Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Verlag Original Publication: Heidelberg, Springer International. |
| مواضيع طبية MeSH: | Cough*/drug therapy , Nitric Oxide*/metabolism , Nitric Oxide*/analysis, Humans ; Female ; Middle Aged ; Male ; Prospective Studies ; Administration, Inhalation ; Chronic Disease ; Aged ; Treatment Outcome ; Fractional Exhaled Nitric Oxide Testing ; Androstadienes/administration & dosage ; Adult ; Severity of Illness Index ; Surveys and Questionnaires ; Exhalation ; Adrenal Cortex Hormones/administration & dosage ; Chronic Cough |
| مستخلص: | This study aimed to investigate the effects of high-dose inhaled corticosteroids (ICS) on chronic cough patients with elevated fractional exhaled nitric oxide (FeNO) levels. In a prospective study, adults with chronic cough and FeNO ≥ 25 ppb, without any other apparent etiology, received fluticasone furoate (200 mcg) for three weeks. Outcomes were evaluated using FeNO levels, cough severity, and Leicester Cough Questionnaire (LCQ) before and after treatment. Of the fifty participants (average age: 58.4 years; 58% female), the treatment responder rate (≥ 1.3-point increase in LCQ) was 68%, with a significant improvement in cough and LCQ scores and FeNO levels post-treatment. However, improvements in cough did not significantly correlate with changes in FeNO levels. These findings support the guideline recommendations for a short-term ICS trial in adults with chronic cough and elevated FeNO levels, but the lack of correlations between FeNO levels and cough raises questions about their direct mechanistic link. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Asthma; Corticosteroids; Cough; Eosinophilic bronchitis; Fractional exhaled nitric oxide |
| المشرفين على المادة: | 31C4KY9ESH (Nitric Oxide) JS86977WNV (fluticasone furoate) 0 (Androstadienes) 0 (Adrenal Cortex Hormones) |
| تواريخ الأحداث: | Date Created: 20240511 Date Completed: 20240531 Latest Revision: 20240531 |
| رمز التحديث: | 20240601 |
| DOI: | 10.1007/s00408-024-00698-y |
| PMID: | 38733542 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-1750 |
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| DOI: | 10.1007/s00408-024-00698-y |