دورية أكاديمية
أعرض في EDS

Magnetic quaternary ammonium polymer bearing porous agarose for selective extraction of Aristolochic acids in the plasma.

التفاصيل البيبلوغرافية
العنوان: Magnetic quaternary ammonium polymer bearing porous agarose for selective extraction of Aristolochic acids in the plasma.
المؤلفون: Liu X; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China., Luo Y; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China., Fan Y; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China., Cao X; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China; Research Center of Analysis and Measurement, Fudan University, 2005 Songhu Road, Shanghai 200438, PR China. Electronic address: 072037001@fudan.edu.cn., Lu J; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China. Electronic address: ljaaa111@163.com., Song G; Research Center of Analysis and Measurement, Fudan University, 2005 Songhu Road, Shanghai 200438, PR China. Electronic address: gxsong@fudan.edu.cn., Deng C; Department of Chemistry, Institutes of Biomedical Sciences, Fudan University, 2005 Songhu Road, Shanghai 200438, PR China.
المصدر: Journal of chromatography. A [J Chromatogr A] 2024 Jul 05; Vol. 1726, pp. 464965. Date of Electronic Publication: 2024 May 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier, 1993-
مواضيع طبية MeSH: Aristolochic Acids*/chemistry , Aristolochic Acids*/isolation & purification , Aristolochic Acids*/blood , Sepharose*/chemistry , Solid Phase Extraction*/methods , Quaternary Ammonium Compounds*/chemistry, Chromatography, High Pressure Liquid/methods ; Porosity ; Limit of Detection ; Animals ; Humans ; Polymers/chemistry ; Adsorption ; Reproducibility of Results
مستخلص: Aristolochic acids (AAs) naturally occurring in the herbal genus Aristolochia are associated with a high risk of kidney failure, multiple tumors and cancers. However, approaches with high selectivity and rapidity for measuring AAs in biological samples are still inadequate. Inspired by the mechanism of AAs-induced nephrotoxicity, we designed a hybrid magnetic polymer-porous agarose (denoted as MNs@SiO 2 M@DNV-A), mimicking the effect of basic and aromatic residues of organic anion transporter 1 (OAT1) for efficient enriching aristolochic acid I (AA I) and aristolochic acid II (AA II) in the plasma. The monomers of vinylbenzyl trimethylammonium chloride (VBTAC), N-vinyl-2-pyrrolidinone (NVP) and divinylbenzene (DVB) were employed to construct the polymer layer, which provided a selective adsorption for AAs by multiple interactions. The porous agarose shell contributed to remove interfering proteins in the plasma samples. A magnetic solid-phase extraction (MSPE) based on the proposed composite enhanced the selectivity toward AA I and AA II in the plasma samples. In combination of HPLC analysis, the proposed method was proved to be applicable to fast and specific quantification of AAs in blood samples, which was characterized by a good linearity, high sensitivity, acceptable recovery, excellent repeatability and satisfactory reusability.
Competing Interests: Declaration of competing interest We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Aristolochic acids; Cationic polymer; Magnetic porous agarose; Magnetic solid-phase extraction; Plasma analysis
المشرفين على المادة: 0 (aristolochic acid I)
0 (aristolochic acid II)
تواريخ الأحداث: Date Created: 20240511 Date Completed: 20240521 Latest Revision: 20240521
رمز التحديث: 20240522
DOI: 10.1016/j.chroma.2024.464965
PMID: 38733925
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3778
DOI:10.1016/j.chroma.2024.464965