دورية أكاديمية
Pharmacokinetics of tildipirosin in estuarine (Crocodylus porosus) and freshwater (Crocodylus siamensis) crocodiles.
| العنوان: | Pharmacokinetics of tildipirosin in estuarine (Crocodylus porosus) and freshwater (Crocodylus siamensis) crocodiles. |
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| المؤلفون: | Poapolathep S; Department of Pharmacology, Faculty of Veterinary Medicine, Kasertsart University, Bangkok 10900, Thailand., Escudero E; Department of Pharmacology, University of Murcia, Campus de Espinardo, Murcia 30100, Spain., Klangkaew N; Department of Pharmacology, Faculty of Veterinary Medicine, Kasertsart University, Bangkok 10900, Thailand., Phaochoosak N; Department of Pharmacology, Faculty of Veterinary Medicine, Kasertsart University, Bangkok 10900, Thailand., Wongwaipairoj T; Wongveerakit Crocodile Farm, Bho Ploi, Kanchanaburi, Thailand., Marin P; Department of Pharmacology, University of Murcia, Campus de Espinardo, Murcia 30100, Spain., Poapolathep A; Department of Pharmacology, Faculty of Veterinary Medicine, Kasertsart University, Bangkok 10900, Thailand. Electronic address: amnart.p@ku.th. |
| المصدر: | Veterinary journal (London, England : 1997) [Vet J] 2024 Jun; Vol. 305, pp. 106130. Date of Electronic Publication: 2024 May 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Balliere Tindall Country of Publication: England NLM ID: 9706281 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2971 (Electronic) Linking ISSN: 10900233 NLM ISO Abbreviation: Vet J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Balliere Tindall Original Publication: London : Ballière Tindall, c1997- |
| مواضيع طبية MeSH: | Alligators and Crocodiles* , Tylosin*/analogs & derivatives , Tylosin*/pharmacokinetics , Tylosin*/administration & dosage, Animals ; Injections, Intramuscular/veterinary ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/administration & dosage ; Injections, Intravenous/veterinary ; Fresh Water ; Half-Life ; Biological Availability ; Area Under Curve |
| مستخلص: | Tildipirosin is a macrolide antimicrobial. It is authorised for the treatment and prevention of respiratory disease in cattle and pigs. There are no data on its administration in crocodiles. Therefore, this study evaluated the disposition kinetics of tildipirosin after intravenous (dose: 2 mg/kg) and intramuscular (doses: 2 and 4 mg/kg) administration in two crocodilian species (estuarine and freshwater; n = 5). Tildipirosin plasma concentrations were quantified by a validated HPLC method. Plasma concentrations obtained at each extraction time were analysed by non-compartmental methods. In the estuarine and freshwater crocodiles, the apparent volumes of distribution of tildipirosin after intravenous administration were 0.36 ± 0.10 and 1.48 ± 0.26 L/kg, respectively. These values, suggesting poorer tissue distribution, were much lower than those obtained in mammals. There was complete bioavailability of tildipirosin after intramuscular route at a dose of 2 mg/kg; however, at a dose of 4 mg/kg the bioavailability decreased by about 20-25 %. Furthermore, the pharmacokinetics of tildipirosin were markedly different in the two crocodilian species. Considering a MIC of 0.5 µg/mL, the surrogate marker AUC Competing Interests: Declaration of Competing Interest None of the authors has any financial or personal relationships that could inappropriately influence or bias the content of the paper (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Crocodiles; Macrolides; Pharmacokinetics; Tildipirosin |
| المشرفين على المادة: | YEF4JXN031 (Tylosin) 0 (20,23-dipiperidinyl-mycaminosyl-tylonolide) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20240511 Date Completed: 20240619 Latest Revision: 20240619 |
| رمز التحديث: | 20240620 |
| DOI: | 10.1016/j.tvjl.2024.106130 |
| PMID: | 38734403 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-2971 |
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| DOI: | 10.1016/j.tvjl.2024.106130 |