دورية أكاديمية
أعرض في EDS

Chronic circadian rhythm disorder induces heart failure with preserved ejection fraction-like phenotype through the Clock-sGC-cGMP-PKG1 signaling pathway.

التفاصيل البيبلوغرافية
العنوان: Chronic circadian rhythm disorder induces heart failure with preserved ejection fraction-like phenotype through the Clock-sGC-cGMP-PKG1 signaling pathway.
المؤلفون: Che Y; Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-8550, Japan., Shimizu Y; Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-8550, Japan. shimi123@med.nagoya-u.ac.jp., Hayashi T; Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-8550, Japan., Suzuki J; Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-8550, Japan., Pu Z; Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-8550, Japan., Tsuzuki K; Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-8550, Japan., Narita S; Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-8550, Japan., Shibata R; Department of Advanced Cardiovascular Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan., Murohara T; Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-8550, Japan.
المصدر: Scientific reports [Sci Rep] 2024 May 11; Vol. 14 (1), pp. 10777. Date of Electronic Publication: 2024 May 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Chronobiology Disorders*/complications , Chronobiology Disorders*/metabolism , CLOCK Proteins*/metabolism , CLOCK Proteins*/genetics , Cyclic GMP*/metabolism , Heart Failure*/metabolism , Heart Failure*/etiology , Heart Failure*/physiopathology , Soluble Guanylyl Cyclase*/metabolism, Animals ; Male ; Mice ; Circadian Rhythm/physiology ; Cyclic GMP-Dependent Protein Kinase Type I/metabolism ; Cyclic GMP-Dependent Protein Kinase Type I/genetics ; Disease Models, Animal ; Mice, Inbred C57BL ; Myocytes, Cardiac/metabolism ; Phenotype ; Signal Transduction ; Stroke Volume
مستخلص: Emerging evidence has documented that circadian rhythm disorders could be related to cardiovascular diseases. However, there is limited knowledge on the direct adverse effects of circadian misalignment on the heart. This study aimed to investigate the effect of chronic circadian rhythm disorder on heart homeostasis in a mouse model of consistent jetlag. The jetlag model was induced in mice by a serial 8-h phase advance of the light cycle using a light-controlled isolation box every 4 days for up to 3 months. Herein, we demonstrated for the first time that chronic circadian rhythm disorder established in the mouse jetlag model could lead to HFpEF-like phenotype such as cardiac hypertrophy, cardiac fibrosis, and cardiac diastolic dysfunction, following the attenuation of the Clock-sGC-cGMP-PKG1 signaling. In addition, clock gene knock down in cardiomyocytes induced hypertrophy via decreased sGC-cGMP-PKG signaling pathway. Furthermore, treatment with an sGC-activator riociguat directly attenuated the adverse effects of jetlag model-induced cardiac hypertrophy, cardiac fibrosis, and cardiac diastolic dysfunction. Our data suggest that circadian rhythm disruption could induce HFpEF-like phenotype through downregulation of the clock-sGC-cGMP-PKG1 signaling pathway. sGC could be one of the molecular targets against circadian rhythm disorder-related heart disease.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 22K08201 Ministry of Education, Culture, Sports, Science and Technology of Japan; 2020 4-13 Mochida Memorial Foundation for Medical and Pharmaceutical Research
فهرسة مساهمة: Keywords: Clock; Cyclic GMP; HFpEF; Jetlag; Riociguat; Soluble guanylate cyclase
المشرفين على المادة: EC 2.3.1.48 (Clock protein, mouse)
EC 2.3.1.48 (CLOCK Proteins)
H2D2X058MU (Cyclic GMP)
EC 2.7.11.12 (Cyclic GMP-Dependent Protein Kinase Type I)
EC 4.6.1.2 (Soluble Guanylyl Cyclase)
تواريخ الأحداث: Date Created: 20240511 Date Completed: 20240511 Latest Revision: 20240701
رمز التحديث: 20240702
مُعرف محوري في PubMed: PMC11088651
DOI: 10.1038/s41598-024-61710-2
PMID: 38734687
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-61710-2