دورية أكاديمية
High correlated color temperature artificial lighting impairs retinal pigment epithelium integrity and chloride ion transport: A potential mechanism for choroidal thinning.
| العنوان: | High correlated color temperature artificial lighting impairs retinal pigment epithelium integrity and chloride ion transport: A potential mechanism for choroidal thinning. |
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| المؤلفون: | Zhang C; Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130041, PR China., Jiao Q; Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130041, PR China., Wang M; Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130041, PR China., Zhu Z; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao, 266000, PR China., Zhao J; Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130041, PR China., Zheng Y; Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130041, PR China. Electronic address: yjzheng@jlu.edu.cn. |
| المصدر: | Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jul 23; Vol. 718, pp. 150078. Date of Electronic Publication: 2024 May 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002- >: San Diego, CA : Elsevier Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Retinal Pigment Epithelium*/metabolism , Retinal Pigment Epithelium*/radiation effects , Retinal Pigment Epithelium*/pathology , Choroid*/metabolism , Choroid*/radiation effects , Choroid*/pathology , Ion Transport*/radiation effects , Chlorides*/metabolism, Animals ; Lighting/methods ; Temperature ; Color ; Tight Junctions/metabolism ; Myopia/metabolism ; Myopia/pathology ; Myopia/etiology |
| مستخلص: | Among the environmental factors contributing to myopia, the role of correlated color temperature (CCT) of ambient light emerges as a key element warranting in-depth investigation. The choroid, a highly vascularized and dynamic structure, often undergoes thinning during the progression of myopia, though the precise mechanism remains elusive. The retinal pigment epithelium (RPE), the outermost layer of the retina, plays a pivotal role in regulating the transport of ion and fluid between the subretinal space and the choroid. A hypothesis suggests that variations in choroidal thickness (ChT) may be modulated by transepithelial fluid movement across the RPE. Our experimental results demonstrate that high CCT illumination significantly compromised the integrity of tight junctions in the RPE and disrupted chloride ion transport. This functional impairment of the RPE may lead to a reduction in fluid transfer across the RPE, consequently resulting in choroidal thinning and potentially accelerating axial elongation. Our findings provide support for the crucial role of the RPE in regulating ChT. Furthermore, we emphasize the potential hazards posed by high CCT artificial illumination on the RPE, the choroid, and refractive development, underscoring the importance of developing eye-friendly artificial light sources to aid in the prevention and control of myopia. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Chloride ion transport; Choroidal thickness; Correlated color temperature; Myopia; Retinal pigment epithelium; Tight junction |
| تواريخ الأحداث: | Date Created: 20240512 Date Completed: 20240521 Latest Revision: 20240521 |
| رمز التحديث: | 20240522 |
| DOI: | 10.1016/j.bbrc.2024.150078 |
| PMID: | 38735140 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2104 |
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| DOI: | 10.1016/j.bbrc.2024.150078 |