دورية أكاديمية
أعرض في EDS

Impact of Plant-Based Dietary Fibers on Metabolic Homeostasis in High-Fat Diet Mice via Alterations in the Gut Microbiota and Metabolites.

التفاصيل البيبلوغرافية
العنوان: Impact of Plant-Based Dietary Fibers on Metabolic Homeostasis in High-Fat Diet Mice via Alterations in the Gut Microbiota and Metabolites.
المؤلفون: Howard EJ; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, United States., Meyer RK; School of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ, United States., Weninger SN; Department of Physiology, University of Arizona, Tucson, AZ, United States., Martinez T; Department of Physiology, University of Arizona, Tucson, AZ, United States., Wachsmuth HR; Department of Physiology, University of Arizona, Tucson, AZ, United States., Pignitter M; Institute of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria., Auñon-Lopez A; Institute of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria; Vienna Doctoral School in Chemistry (DoSChem), Faculty of Chemistry, University of Vienna, Vienna, Austria., Kangath A; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, United States., Duszka K; Department of Nutritional Sciences, University of Vienna, Vienna, Austria., Gu H; College of Health Solutions, Arizona State University, Phoenix, AZ, United States., Schiro G; PANDA Core for Genomics and Microbiome Research, Steele Children's Research Center, University of Arizona, Tucson, AZ, United States., Laubtiz D; PANDA Core for Genomics and Microbiome Research, Steele Children's Research Center, University of Arizona, Tucson, AZ, United States., Duca FA; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, United States; BIO5 Institute, University of Arizona, Tucson, AZ, United States. Electronic address: faduca@arizona.edu.
المصدر: The Journal of nutrition [J Nutr] 2024 Jul; Vol. 154 (7), pp. 2014-2028. Date of Electronic Publication: 2024 May 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0404243 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-6100 (Electronic) Linking ISSN: 00223166 NLM ISO Abbreviation: J Nutr Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York, NY] : Elsevier
Original Publication: 1928-1933 : Springfield, Ill. : C. C. Thomas
مواضيع طبية MeSH: Dietary Fiber*/pharmacology , Dietary Fiber*/administration & dosage , Gastrointestinal Microbiome*/drug effects , Diet, High-Fat* , Homeostasis* , Mice, Inbred C57BL*, Animals ; Mice ; Male ; beta-Glucans/pharmacology ; beta-Glucans/administration & dosage ; Pectins/pharmacology ; Pectins/administration & dosage
مستخلص: Background: The gut microbiota contributes to metabolic disease, and diet shapes the gut microbiota, emphasizing the need to better understand how diet impacts metabolic disease via gut microbiota alterations. Fiber intake is linked with improvements in metabolic homeostasis in rodents and humans, which is associated with changes in the gut microbiota. However, dietary fiber is extremely heterogeneous, and it is imperative to comprehensively analyze the impact of various plant-based fibers on metabolic homeostasis in an identical setting and compare the impact of alterations in the gut microbiota and bacterially derived metabolites from different fiber sources.
Objectives: The objective of this study was to analyze the impact of different plant-based fibers (pectin, β-glucan, wheat dextrin, resistant starch, and cellulose as a control) on metabolic homeostasis through alterations in the gut microbiota and its metabolites in high-fat diet (HFD)-fed mice.
Methods: HFD-fed mice were supplemented with 5 different fiber types (pectin, β-glucan, wheat dextrin, resistant starch, or cellulose as a control) at 10% (wt/wt) for 18 wk (n = 12/group), measuring body weight, adiposity, indirect calorimetry, glucose tolerance, and the gut microbiota and metabolites.
Results: Only β-glucan supplementation during HFD-feeding decreased adiposity and body weight gain and improved glucose tolerance compared with HFD-cellulose, whereas all other fibers had no effect. This was associated with increased energy expenditure and locomotor activity in mice compared with HFD-cellulose. All fibers supplemented into an HFD uniquely shifted the intestinal microbiota and cecal short-chain fatty acids; however, only β-glucan supplementation increased cecal butyrate concentrations. Lastly, all fibers altered the small-intestinal microbiota and portal bile acid composition.
Conclusions: These findings demonstrate that β-glucan consumption is a promising dietary strategy for metabolic disease, possibly via increased energy expenditure through alterations in the gut microbiota and bacterial metabolites in mice.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
References: Int J Biol Macromol. 2021 Jun 1;180:458-469. (PMID: 33711371)
Diabetes. 2017 May;66(5):1405-1418. (PMID: 28223285)
Compr Rev Food Sci Food Saf. 2006 Jan;5(1):1-17. (PMID: 33412740)
Cell Death Discov. 2021 Aug 7;7(1):207. (PMID: 34365464)
Obesity (Silver Spring). 2015 Apr;23(4):769-78. (PMID: 25820256)
Nat Rev Endocrinol. 2019 Dec;15(12):701-712. (PMID: 31616073)
Appl Environ Microbiol. 2018 Jul 17;84(15):. (PMID: 29802187)
J Endocrinol. 2019 Aug;242(2):R1-R8. (PMID: 31042668)
Front Microbiol. 2018 Jul 20;9:1618. (PMID: 30072976)
Science. 2016 Apr 29;352(6285):560-4. (PMID: 27126039)
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71. (PMID: 23671105)
J Nutr. 2018 Apr 1;148(4):562-572. (PMID: 29659960)
PLoS One. 2018 Apr 26;13(4):e0196579. (PMID: 29698465)
Sci Rep. 2018 Oct 22;8(1):15566. (PMID: 30349136)
Annu Rev Biochem. 2003;72:137-74. (PMID: 12543708)
Br J Nutr. 2015 Jan 28;113(2):321-30. (PMID: 27028002)
PLoS One. 2015 Oct 08;10(10):e0140392. (PMID: 26447990)
Curr Allergy Asthma Rep. 2021 Sep 10;21(10):43. (PMID: 34505973)
Gut Microbes. 2020 Nov 9;12(1):1847627. (PMID: 33319645)
Mol Metab. 2016 Nov 04;6(1):48-60. (PMID: 28123937)
J Nutr. 2007 Nov;137(11 Suppl):2493S-2502S. (PMID: 17951492)
Int J Obes (Lond). 2017 Jul;41(7):1099-1105. (PMID: 28286339)
Cell Metab. 2018 Sep 4;28(3):415-431.e4. (PMID: 30017356)
Food Funct. 2021 Nov 29;12(23):12098-12114. (PMID: 34784410)
Nat Methods. 2016 Jul;13(7):581-3. (PMID: 27214047)
PLoS One. 2016 May 25;11(5):e0155871. (PMID: 27224646)
Molecules. 2019 Jan 22;24(3):. (PMID: 30678271)
J Clin Invest. 2006 Apr;116(4):1102-9. (PMID: 16557297)
Nature. 2006 Jan 26;439(7075):484-9. (PMID: 16400329)
Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1160-6. (PMID: 18796545)
FASEB J. 2016 Aug;30(8):2720-32. (PMID: 27059718)
Obesity (Silver Spring). 2022 Jul;30(7):1442-1452. (PMID: 35785478)
Gut. 2021 Sep;70(9):1675-1683. (PMID: 33087489)
J Agric Food Chem. 2000 Feb;48(2):270-8. (PMID: 10691627)
Food Funct. 2020 Mar 1;11(3):1982-1995. (PMID: 32080691)
Obes Res. 2005 Jun;13(6):1000-7. (PMID: 15976142)
Gastroenterology. 2016 Nov;151(5):845-859. (PMID: 27639801)
Appl Environ Microbiol. 2007 Aug;73(16):5261-7. (PMID: 17586664)
Nature. 2014 Jan 23;505(7484):559-63. (PMID: 24336217)
Diabetes Obes Metab. 2018 Apr;20(4):1034-1039. (PMID: 29134744)
Liver Int. 2015 Apr;35(4):1133-1144. (PMID: 25156247)
Diabetes. 2009 Jul;58(7):1509-17. (PMID: 19366864)
Cells. 2019 Mar 16;8(3):. (PMID: 30884843)
Am J Physiol Gastrointest Liver Physiol. 2015 Oct 1;309(7):G528-41. (PMID: 26185332)
Mol Nutr Food Res. 2011 Oct;55(10):1499-508. (PMID: 21638778)
Gut. 2018 Jul;67(7):1269-1279. (PMID: 29101261)
Cell Host Microbe. 2018 Jan 10;23(1):41-53.e4. (PMID: 29276170)
Metabolism. 1998 Nov;47(11):1354-9. (PMID: 9826212)
Food Funct. 2022 Nov 14;13(22):11664-11675. (PMID: 36278802)
J Nutr Health Aging. 2009 Aug;13(7):602-6. (PMID: 19621195)
Nutr Diabetes. 2018 Mar 7;8(1):15. (PMID: 29549311)
Metabolomics. 2022 Jul 23;18(8):60. (PMID: 35871176)
Carbohydr Polym. 2022 Apr 1;281:119046. (PMID: 35074119)
ISME J. 2019 Jun;13(6):1520-1534. (PMID: 30742017)
J Clin Endocrinol Metab. 2014 Apr;99(4):1442-51. (PMID: 24432996)
Br J Nutr. 2015 Sep 28;114(6):899-907. (PMID: 26259632)
Am J Clin Nutr. 2005 Feb;81(2):341-54. (PMID: 15699220)
Nutrients. 2019 Jul 16;11(7):. (PMID: 31315227)
Int J Food Sci Nutr. 2011 Sep;62(6):628-35. (PMID: 21591985)
Cell Metab. 2016 Jul 12;24(1):41-50. (PMID: 27320064)
Toxicol Sci. 2021 Jan 6;179(1):14-30. (PMID: 33078840)
Nature. 2013 Aug 29;500(7464):541-6. (PMID: 23985870)
Lipids Health Dis. 2019 Nov 24;18(1):205. (PMID: 31760943)
J Anim Sci. 2022 Feb 1;100(2):. (PMID: 34967874)
Sci Transl Med. 2009 Nov 11;1(6):6ra14. (PMID: 20368178)
Nutr Metab (Lond). 2023 Oct 19;20(1):44. (PMID: 37858106)
Metabolites. 2023 May 16;13(5):. (PMID: 37233701)
Am J Clin Nutr. 2009 Jun;89(6):1751-9. (PMID: 19386741)
Nutr Metab (Lond). 2014 Aug 14;11:36. (PMID: 25152765)
Crit Rev Food Sci Nutr. 2006;46(8):649-63. (PMID: 17092830)
J Agric Food Chem. 2022 Nov 30;70(47):14864-14876. (PMID: 36378195)
Nutrients. 2010 Dec;2(12):1266-89. (PMID: 22254008)
Cell Host Microbe. 2018 Jun 13;23(6):705-715. (PMID: 29902436)
Mol Metab. 2021 Feb;44:101132. (PMID: 33264656)
Nature. 2016 Jun 08;534(7606):213-7. (PMID: 27279214)
Microbiome. 2023 Aug 2;11(1):169. (PMID: 37533066)
Curr Protoc. 2021 Jun;1(6):e177. (PMID: 34165916)
Proc Natl Acad Sci U S A. 2011 May 10;108(19):8030-5. (PMID: 21518883)
Cell. 2018 Nov 1;175(4):962-972.e10. (PMID: 30388453)
فهرسة مساهمة: Keywords: dietary fiber; gut microbiota; metabolic homeostasis; metabolites; obesity
المشرفين على المادة: 0 (Dietary Fiber)
0 (beta-Glucans)
89NA02M4RX (Pectins)
تواريخ الأحداث: Date Created: 20240512 Date Completed: 20240705 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11282473
DOI: 10.1016/j.tjnut.2024.05.003
PMID: 38735572
قاعدة البيانات: MEDLINE
الوصف
تدمد:1541-6100
DOI:10.1016/j.tjnut.2024.05.003