دورية أكاديمية
Somatic mutational profiling and clinical impact of driver genes in Latin-Iberian medulloblastomas: Towards precision medicine.
العنوان: | Somatic mutational profiling and clinical impact of driver genes in Latin-Iberian medulloblastomas: Towards precision medicine. |
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المؤلفون: | Barateiro LGRP; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil., de Oliveira Cavagna R; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil., Dos Reis MB; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil., de Paula FE; Molecular Diagnostic Laboratory, Barretos Cancer Hospital, Barretos, Brazil., Teixeira GR; Molecular Diagnostic Laboratory, Barretos Cancer Hospital, Barretos, Brazil.; Department of Pathology, Barretos Cancer Hospital, Barretos, Brazil., Moreno DA; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil., Bonatelli M; Molecular Diagnostic Laboratory, Barretos Cancer Hospital, Barretos, Brazil., Santana I; Department of Pathology, Barretos Cancer Hospital, Barretos, Brazil., Saggioro FP; Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Neder L; Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Stavale JN; Federal University of São Paulo, São Paulo, Brazil., Malheiros SMF; Federal University of São Paulo, São Paulo, Brazil., Garcia-Rivello H; Italian Hospital of Buenos Aires, Buenos Aires, Argentina., Christiansen S; Italian Hospital of Buenos Aires, Buenos Aires, Argentina., Nunes S; São João Hospital, Porto, Portugal., da Costa MJG; São João Hospital, Porto, Portugal., Pinheiro J; São João Hospital, Porto, Portugal., Júnior CA; Pediatric Department, Barretos Cancer Hospital, Barretos, Brazil., Mançano BM; Pediatric Department, Barretos Cancer Hospital, Barretos, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.; Molecular Diagnostic Laboratory, Barretos Cancer Hospital, Barretos, Brazil.; Life and Health Sciences Research Institute (ICVS), Medical School, University of Minho, Braga, Portugal. |
المصدر: | Neuropathology : official journal of the Japanese Society of Neuropathology [Neuropathology] 2024 May 12. Date of Electronic Publication: 2024 May 12. |
Publication Model: | Ahead of Print |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Blackwell Science Asia Country of Publication: Australia NLM ID: 9606526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1789 (Electronic) Linking ISSN: 09196544 NLM ISO Abbreviation: Neuropathology Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2000-> : Melbourne, Australia : Blackwell Science Asia Original Publication: Sendai, Japan : The Society, [1993- |
مستخلص: | Medulloblastoma (MB) is the most prevalent malignant brain tumor in children, known for its heterogeneity and treatment-associated toxicity, and there is a critical need for new therapeutic targets. We analyzed the somatic mutation profile of 15 driver genes in 69 Latin-Iberian molecularly characterized medulloblastomas using the Illumina TruSight Tumor 15 panel. We classified the variants based on their clinical impact and oncogenicity. Among the patients, 66.7% were MB (© 2024 The Authors. Neuropathology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Neuropathology.) |
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معلومات مُعتمدة: | Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Hospital de Câncer de Barretos; Public Ministry of Labor Campinas; Brazilian Ministry of Health (MoH); the National Council for Scientific and Technological Development; 16/2023 Brazilian National Program of Genomics and Precision Health; Coordination for the Improvement of Higher Education Personnel; 2021/13861-0 São Paulo Research Foundation |
فهرسة مساهمة: | Keywords: medulloblastoma; mutational profile; next‐generation sequencing; precision medicine; somatic variants |
تواريخ الأحداث: | Date Created: 20240513 Latest Revision: 20240513 |
رمز التحديث: | 20240513 |
DOI: | 10.1111/neup.12979 |
PMID: | 38736183 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1440-1789 |
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DOI: | 10.1111/neup.12979 |