دورية أكاديمية
Pluronic P123/DMSO Lyotropic Liquid Crystal for Incorporating Bioactive Substances for Topical Application.
| العنوان: | Pluronic P123/DMSO Lyotropic Liquid Crystal for Incorporating Bioactive Substances for Topical Application. |
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| المؤلفون: | Selivanova NM; Physical and Colloid Chemistry Department, Kazan National Research Technological University, 68 Karl Marx St., 420015 Kazan, Russia., Galeeva AI; Physical and Colloid Chemistry Department, Kazan National Research Technological University, 68 Karl Marx St., 420015 Kazan, Russia., Ziganshin MA; Physical Chemistry Department, A.M. Butlerov Institute of Chemistry, Kazan (Volga Region) Federal University, 18 Kremlevskaya St., 420008 Kazan, Russia., Galyametdinov YG; Physical and Colloid Chemistry Department, Kazan National Research Technological University, 68 Karl Marx St., 420015 Kazan, Russia. |
| المصدر: | The journal of physical chemistry. B [J Phys Chem B] 2024 May 23; Vol. 128 (20), pp. 5127-5134. Date of Electronic Publication: 2024 May 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101157530 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5207 (Electronic) Linking ISSN: 15205207 NLM ISO Abbreviation: J Phys Chem B Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society, c1997- |
| مواضيع طبية MeSH: | Liquid Crystals*/chemistry , Ibuprofen*/chemistry , Ibuprofen*/administration & dosage , Poloxalene*/chemistry, Rheology ; Administration, Topical ; Drug Liberation |
| مستخلص: | Lyotropic liquid crystals (LLCs) have attracted considerably growing interest in drug delivery applications over the last years. The structure of LLC matrices is complementary to cell membranes and provides an efficient, controlled, and selective release of drugs. In this work, a complex of experimental methods was used to characterize binary LLCs Pluronic P123/DMSO and triple LLC systems Pluronic P123/DMSO/Ibuprofen, which are interesting as transdermal drug delivery systems. Liquid crystalline, thermal, and rheological properties of LLCs were studied. Concentration and temperature areas of the lyomesophase existence were found, and phase transition enthalpies were evaluated. Intermolecular interactions among the components were studied by infrared (IR) spectroscopy. In vitro studies of Ibuprofen (Ibu) release from various LLCs allow differentiation of its release depending on the polymer content. Atomic force microscopy and contact angle methods were used to characterize the surface morphology of the hydrophobic membrane, which was used as a stratum corneum model, and also evaluate the adhesion work of the LLCs. A complex analysis of the results provided by these experimental methods allowed revealing correlations between the phase behavior and rheological characteristics of the LLCs and release kinetics of ibuprofen. The proposed biocompatible systems have considerable potential for a transdermal delivery of bioactive substances. |
| المشرفين على المادة: | WK2XYI10QM (Ibuprofen) 2E9U4Y94DB (pluronic block copolymer P123) 9003-11-6 (Poloxalene) |
| تواريخ الأحداث: | Date Created: 20240513 Date Completed: 20240523 Latest Revision: 20240523 |
| رمز التحديث: | 20240523 |
| DOI: | 10.1021/acs.jpcb.4c00929 |
| PMID: | 38736379 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5207 |
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| DOI: | 10.1021/acs.jpcb.4c00929 |