دورية أكاديمية
Synchronous papillary and follicular thyroid carcinomas: the first retrospective cohort study and literature review.
| العنوان: | Synchronous papillary and follicular thyroid carcinomas: the first retrospective cohort study and literature review. |
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| المؤلفون: | Ye WD; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Tan LC; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Veryaskina YA; Laboratory of Gene Engineering, Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russian Federation.; Department of the Structure and Function of Chromosomes, Laboratory of Molecular Genetics Institute of Molecular and Cellular Biology, SB RAS, Novosibirsk, Russian Federation., Han PZ; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Yu PC; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Shi X; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Liu WL; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Kai ZT; Department of Bioinformatics, Zhejiang Shaoxing Topgen Biomedical Technology Co., Ltd., Shanghai, China., Lin RJ; Department of Technology, Zhejiang Topgen Clinical Laboratory Co., Ltd., Huzhou, China., Huang LS; Department of Medicine, Zhejiang Shaoxing Topgen Biomedical Technology Co., Ltd., Shanghai, China., Semenov A; Saint Petersburg State University Hospital, Saint Petersburg, Russian Federation., Zhimulev IF; Department of the Structure and Function of Chromosomes, Laboratory of Molecular Genetics Institute of Molecular and Cellular Biology, SB RAS, Novosibirsk, Russian Federation., Ji QH; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Qu N; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Titov SE; Department of the Structure and Function of Chromosomes, Laboratory of Molecular Genetics Institute of Molecular and Cellular Biology, SB RAS, Novosibirsk, Russian Federation.; AO Vector-Best, Novosibirsk, Russian Federation., Wang YL; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. |
| المصدر: | Translational cancer research [Transl Cancer Res] 2024 Apr 30; Vol. 13 (4), pp. 1924-1935. Date of Electronic Publication: 2024 Apr 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pioneer Bioscience Publishing Company Country of Publication: China NLM ID: 101585958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2219-6803 (Electronic) Linking ISSN: 2218676X NLM ISO Abbreviation: Transl Cancer Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Hong Kong] : Pioneer Bioscience Publishing Company, [2012]- |
| مستخلص: | Background: Papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) contribute to more than 95% of thyroid malignancies. However, synchronous PTC and FTC are less common; it is most commonly discovered incidentally as synchronous malignancies during operation, which adds difficulties to intraoperative decision-making and postoperative treatment. Therefore, we analyzed the clinicopathological characteristics and prognosis of patients with PTC and FTC in our center. Methods: We conducted a search of single PTC, single FTC, and synchronous PTC/FTC patients who received initial surgery treatment at Fudan University Shanghai Cancer Center from 2006 to 2018 and collected paraffin-embedded samples of synchronous patients. Clinicopathological characteristics were collected from the electronic medical record system. Follow-up was performed through telephone contact or medical records. Exome sequencing was performed by ThyroLead panel. Results: Total of 42 synchronous PTC/FTC patients, 244 single FTC patients, and 2,959 single PTC patients were included. It showed a similarity between the clinicopathological features of synchronous thyroid cancer patients and single PTC patients, with a greater proportion of females, higher probabilities of lymph node metastasis, and higher rate of concurrence of Hashimoto's disease. The disease-free survival (DFS) curve indicated a worse prognosis of the synchronous group and single PTC group compared to the single FTC group, who had a propensity for neck lymph node recurrence; however, logistic multivariate regression analysis did not find any factor related to recurrence in the synchronous group. After re-checking pathology, DNA extraction, and quality control, genetic alteration information of 62 samples including primary tumors and metastatic lymph nodes from 35 synchronous cancer patients was displayed. In total, 81 mutations and 1 fusion gene were identified, including mutations related to outcomes and targeted therapy. Besides, some rare mutations in thyroid cancer were found in these patients. Conclusions: To conclude, synchronous PTC/FTC tend to be incidentally discovered during or after operation, behaving more like single PTC. The prognosis of synchronous patients is worse than that of single FTC patients and supplemental cervical lymph node dissection, total thyroidectomy, and postoperative radioiodine therapy should be taken into consideration after diagnosis. The next-generation sequencing (NGS) showed a unique molecular feature of synchronous patients with some rare mutations. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-23-1526/coif). Z.T.K. is an employee from the Department of Bioinformatics, Zhejiang Shaoxing Topgen Biomedical Technology Co., Ltd. R.J.L. is an employee from the Department of Technology, Zhejiang Topgen Clinical Laboratory Co., Ltd. L.S.H. is an employee from Department of Bioinformatics, Zhejiang Shaoxing Topgen Biomedical Technology Co., Ltd. S.E.T. is an employee from AO Vector-Best, Novosibirsk, Russian Federation. The other authors have no conflicts of interest to declare. (2024 Translational Cancer Research. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Synchronous thyroid carcinoma; follicular thyroid carcinoma (FTC); next-generation sequencing (NGS); papillary thyroid carcinoma (PTC) |
| تواريخ الأحداث: | Date Created: 20240513 Latest Revision: 20240514 |
| رمز التحديث: | 20240514 |
| مُعرف محوري في PubMed: | PMC11082670 |
| DOI: | 10.21037/tcr-23-1526 |
| PMID: | 38737695 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2219-6803 |
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| DOI: | 10.21037/tcr-23-1526 |