دورية أكاديمية
Associations of TSH, free T3, free T4, and conversion ratio with incident hypertension: results from the prospective Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
| العنوان: | Associations of TSH, free T3, free T4, and conversion ratio with incident hypertension: results from the prospective Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). |
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| المؤلفون: | Birck MG; Centro de Pesquisas Clínicas e Epidemiológicas, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.; MGP and CCPSJ share first authorship., Janovsky CCPS; Centro de Pesquisas Clínicas e Epidemiológicas, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.; Serviço de Endocrinologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.; MGP and CCPSJ share first authorship., Goulart AC; Centro de Pesquisas Clínicas e Epidemiológicas, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.; Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SP, Brasil., Meneghini V; Centro de Pesquisas Clínicas e Epidemiológicas, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil., Pititto BA; Departamento de Medicina Preventiva, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil., Sgarbi JA; Unidade de Endocrinologia, Faculdade de Medicina de Marília, Marília, SP, Brasil., Teixeira PFS; Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil., Bensenor IM; Centro de Pesquisas Clínicas e Epidemiológicas, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil, isabensenor@gmail.com. |
| المصدر: | Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2024 May 10; Vol. 68, pp. e230301. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Segmento Farma Editores Country of Publication: Brazil NLM ID: 101652058 Publication Model: Print Cited Medium: Internet ISSN: 2359-4292 (Electronic) Linking ISSN: 23593997 NLM ISO Abbreviation: Arch Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: São Paulo, SP : Segmento Farma Editores |
| مواضيع طبية MeSH: | Hypertension*/epidemiology , Hypertension*/blood , Thyrotropin*/blood , Thyroxine*/blood , Triiodothyronine*/blood, Humans ; Male ; Female ; Brazil/epidemiology ; Middle Aged ; Prospective Studies ; Longitudinal Studies ; Adult ; Incidence ; Hyperthyroidism/blood ; Hyperthyroidism/epidemiology ; Hypothyroidism/blood ; Hypothyroidism/epidemiology ; Risk Factors ; Thyroid Function Tests ; Aged |
| مستخلص: | Objective: To evaluate the association of TSH, free T3 (FT3), free T4 (FT4), and conversion (FT3:FT4) ratio values with incident hypertension. Materials and Methods: The study included data from participants of the ELSA-Brasil study without baseline hypertension. Serum TSH, FT4 and FT3 levels, and FT3:FT4 ratio values were assessed at baseline, and incident hypertension (defined by blood pressure levels ≥ 140/90 mmHg) was estimated over a median of 8.2 years of follow-up. The risk of incident hypertension was evaluated considering a 1-unit increase in TSH, FT4, FT3, and conversion ratio values and after dividing these variables into quintiles for further analysis using Poisson regression with robust variance. The results are presented as relative risks (RR) and 95% confidence intervals (CIs) before and after adjustment for multiple variables. Results: The primary analysis incorporated data from 5,915 euthyroid individuals, and the secondary analysis combined data from all euthyroid individuals, 587 individuals with subclinical hypothyroidism, and 31 individuals with subclinical hyperthyroidism. The rate of incident hypertension was 28% (95% CI: 27%-29.3%). The FT4 levels in the first quintile (0.18-1.06 ng/dL) were significantly associated with incident hypertension (RR: 1.03, 95% CI: 1.01-1.06) at follow-up. The association between FT4 levels in the first quintile and incident hypertension was also observed in the analysis of combined data from euthyroid individuals and participants with subclinical thyroid dysfunction (RR: 1.04, 95% CI: 1.01-1.07). The associations were predominantly observed with systolic blood pressure levels in euthyroid individuals. However, in the combined analysis incorporating euthyroid participants and individuals with subclinical thyroid dysfunction, the associations were more pronounced with diastolic blood pressure levels. Conclusion: Low FT4 levels may be a mild risk factor for incident hypertension in euthyroid individuals and persons with subclinical thyroid dysfunction. |
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| فهرسة مساهمة: | Keywords: Thyroid function tests; cohort studies; hypertension; incidence; thyroid hormones |
| المشرفين على المادة: | 9002-71-5 (Thyrotropin) Q51BO43MG4 (Thyroxine) 06LU7C9H1V (Triiodothyronine) |
| تواريخ الأحداث: | Date Created: 20240513 Date Completed: 20240513 Latest Revision: 20240608 |
| رمز التحديث: | 20240608 |
| مُعرف محوري في PubMed: | PMC11156177 |
| DOI: | 10.20945/2359-4292-2023-0301 |
| PMID: | 38739525 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2359-4292 |
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| DOI: | 10.20945/2359-4292-2023-0301 |