دورية أكاديمية
Ceria Nanoparticle Systems Alleviate Degenerative Changes in Mouse Postovulatory Aging Oocytes by Reducing Oxidative Stress and Improving Mitochondrial Functions.
العنوان: | Ceria Nanoparticle Systems Alleviate Degenerative Changes in Mouse Postovulatory Aging Oocytes by Reducing Oxidative Stress and Improving Mitochondrial Functions. |
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المؤلفون: | Zhang D; Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China., Ji L; Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China., Yang Y; Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China., Weng J; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China., Ma Y; Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China., Liu L; Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China., Ma W; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. |
المصدر: | ACS nano [ACS Nano] 2024 May 28; Vol. 18 (21), pp. 13618-13634. Date of Electronic Publication: 2024 May 13. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington D.C. : American Chemical Society |
مواضيع طبية MeSH: | Oocytes*/drug effects , Oocytes*/metabolism , Oxidative Stress*/drug effects , Mitochondria*/metabolism , Mitochondria*/drug effects , Cerium*/chemistry , Cerium*/pharmacology , Nanoparticles*/chemistry , Thioctic Acid*/chemistry , Thioctic Acid*/pharmacology , Polyethylene Glycols*/chemistry , Polyethylene Glycols*/pharmacology, Animals ; Mice ; Female ; Reactive Oxygen Species/metabolism ; Cellular Senescence/drug effects ; Ovulation/drug effects ; Apoptosis/drug effects |
مستخلص: | Postovulatory aging oocytes usually feature diminished potential for fertilization and poor embryonic development due to enhanced oxidative damage to the subcellular organelles and macromolecules, which stands as a formidable obstacle in assisted reproductive technologies (ART). Here, we developed lipoic acid (LA) and polyethylene glycol (PEG)-modified CeO |
فهرسة مساهمة: | Keywords: LA-PEG-CeNPs; ceria; mitochondria; oocyte; oxidative stress; postovulatory aging |
المشرفين على المادة: | 619G5K328Y (ceric oxide) 30K4522N6T (Cerium) 73Y7P0K73Y (Thioctic Acid) 3WJQ0SDW1A (Polyethylene Glycols) 0 (Reactive Oxygen Species) |
تواريخ الأحداث: | Date Created: 20240513 Date Completed: 20240528 Latest Revision: 20240528 |
رمز التحديث: | 20240528 |
DOI: | 10.1021/acsnano.4c00383 |
PMID: | 38739841 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1936-086X |
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DOI: | 10.1021/acsnano.4c00383 |