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Ceria Nanoparticle Systems Alleviate Degenerative Changes in Mouse Postovulatory Aging Oocytes by Reducing Oxidative Stress and Improving Mitochondrial Functions.

التفاصيل البيبلوغرافية
العنوان: Ceria Nanoparticle Systems Alleviate Degenerative Changes in Mouse Postovulatory Aging Oocytes by Reducing Oxidative Stress and Improving Mitochondrial Functions.
المؤلفون: Zhang D; Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China., Ji L; Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China., Yang Y; Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China., Weng J; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China., Ma Y; Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China., Liu L; Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China., Ma W; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
المصدر: ACS nano [ACS Nano] 2024 May 28; Vol. 18 (21), pp. 13618-13634. Date of Electronic Publication: 2024 May 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington D.C. : American Chemical Society
مواضيع طبية MeSH: Oocytes*/drug effects , Oocytes*/metabolism , Oxidative Stress*/drug effects , Mitochondria*/metabolism , Mitochondria*/drug effects , Cerium*/chemistry , Cerium*/pharmacology , Nanoparticles*/chemistry , Thioctic Acid*/chemistry , Thioctic Acid*/pharmacology , Polyethylene Glycols*/chemistry , Polyethylene Glycols*/pharmacology, Animals ; Mice ; Female ; Reactive Oxygen Species/metabolism ; Cellular Senescence/drug effects ; Ovulation/drug effects ; Apoptosis/drug effects
مستخلص: Postovulatory aging oocytes usually feature diminished potential for fertilization and poor embryonic development due to enhanced oxidative damage to the subcellular organelles and macromolecules, which stands as a formidable obstacle in assisted reproductive technologies (ART). Here, we developed lipoic acid (LA) and polyethylene glycol (PEG)-modified CeO 2 nanoparticles (LA-PEG-CeNPs) with biocompatibility, enzyme-like autocatalytic activity, and free radical scavenging capacity. We further investigated the LA-PEG-CeNPs effect in mouse postovulatory oocytes during in vitro aging. The results showed that LA-PEG-CeNPs dramatically reduced the accumulation of ROS in aging oocytes, improving mitochondrial dysfunction; they also down-regulated the pro-apoptotic activity by rectifying cellular caspase-3, cleaved caspase-3, and Bcl-2 levels. Consistently, this nanoenzyme prominently alleviated the proportion of abnormalities in spindle structure, chromosome alignment, microtubule stability, and filamentous actin (F-actin) distribution in aging oocytes, furthermore decreased oocyte fragmentation, and improved its ability of fertilization and development to blastocyst. Taken together, our finding suggests that LA-PEG-CeNPs can alleviate oxidative stress damage on oocyte quality during postovulatory aging, implying their potential value for clinical practice in assisted reproduction.
فهرسة مساهمة: Keywords: LA-PEG-CeNPs; ceria; mitochondria; oocyte; oxidative stress; postovulatory aging
المشرفين على المادة: 619G5K328Y (ceric oxide)
30K4522N6T (Cerium)
73Y7P0K73Y (Thioctic Acid)
3WJQ0SDW1A (Polyethylene Glycols)
0 (Reactive Oxygen Species)
تواريخ الأحداث: Date Created: 20240513 Date Completed: 20240528 Latest Revision: 20240528
رمز التحديث: 20240528
DOI: 10.1021/acsnano.4c00383
PMID: 38739841
قاعدة البيانات: MEDLINE
الوصف
تدمد:1936-086X
DOI:10.1021/acsnano.4c00383