دورية أكاديمية

Injectable 2D Material-Based Sensor Array for Minimally Invasive Neural Implants.

التفاصيل البيبلوغرافية
العنوان: Injectable 2D Material-Based Sensor Array for Minimally Invasive Neural Implants.
المؤلفون: Kim J; School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea., Hong J; School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea., Park K; School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea., Lee S; gBrain Inc., Incheon, 21984, Republic of Korea., Hoang AT; School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea., Pak S; Department of Neuroscience, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong., Zhao H; Department of Neuroscience, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong., Ji S; School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea., Yang S; Department of Nanobioengineering, Incheon National University, Incheon, 22012, Republic of Korea., Chung CK; Department of Neurosurgery, Seoul National University Hospital, Seoul, 03080, Republic of Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea., Yang S; gBrain Inc., Incheon, 21984, Republic of Korea.; Department of Neuroscience, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong., Ahn JH; School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
المصدر: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Aug; Vol. 36 (32), pp. e2400261. Date of Electronic Publication: 2024 May 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095 (Electronic) Linking ISSN: 09359648 NLM ISO Abbreviation: Adv Mater Subsets: MEDLINE
أسماء مطبوعة: Publication: Sept. 3, 1997- : Weinheim : Wiley-VCH
Original Publication: Deerfield Beach, FL : VCH Publishers, 1989-
مواضيع طبية MeSH: Graphite*/chemistry , Electrodes, Implanted*, Animals ; Rabbits ; Electric Stimulation ; Molybdenum/chemistry ; Disulfides/chemistry ; Minimally Invasive Surgical Procedures/instrumentation ; Injections ; Intracranial Pressure ; Epilepsy/diagnosis
مستخلص: Intracranial implants for diagnosis and treatment of brain diseases have been developed over the past few decades. However, the platform of conventional implantable devices still relies on invasive probes and bulky sensors in conjunction with large-area craniotomy and provides only limited biometric information. Here, an implantable multi-modal sensor array that can be injected through a small hole in the skull and inherently spread out for conformal contact with the cortical surface is reported. The injectable sensor array, composed of graphene multi-channel electrodes for neural recording and electrical stimulation and MoS 2 -based sensors for monitoring intracranial temperature and pressure, is designed based on a mesh structure whose elastic restoring force enables the contracted device to spread out. It is demonstrated that the sensor array injected into a rabbit's head can detect epileptic discharges on the surface of the cortex and mitigate it by electrical stimulation while monitoring both intracranial temperature and pressure. This method provides good potential for implanting a variety of functional devices via minimally invasive surgery.
(© 2024 The Authors. Advanced Materials published by Wiley‐VCH GmbH.)
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معلومات مُعتمدة: 20012355 Ministry of Trade, Industry, and Energy (MOTIE), Korea; NRF-2015R1A3A2066337 National Research Foundation of Korea; 11101922 Research Grants Council of the Hong Kong
فهرسة مساهمة: Keywords: 2D materials; MoS2; graphene; neural recording; sensors
المشرفين على المادة: 7782-42-5 (Graphite)
ZC8B4P503V (molybdenum disulfide)
81AH48963U (Molybdenum)
0 (Disulfides)
تواريخ الأحداث: Date Created: 20240514 Date Completed: 20240808 Latest Revision: 20240808
رمز التحديث: 20240808
DOI: 10.1002/adma.202400261
PMID: 38741451
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-4095
DOI:10.1002/adma.202400261