دورية أكاديمية
New CNS tumor classification: The importance in pediatric neurosurgical practice.
| العنوان: | New CNS tumor classification: The importance in pediatric neurosurgical practice. |
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| المؤلفون: | Del Río RJ; Department of Neurosurgery, Hospital de Pediatría Juan P. Garrahan, Ciudad Autónoma de Buenos Aires, Argentina., Cicutti SE; Department of Neurosurgery, Hospital de Pediatría Juan P. Garrahan, Ciudad Autónoma de Buenos Aires, Argentina., Moreira DC; Department of Oncology, St. Jude Children's Research Hospital, Memphis, United States., Ramos JDG; Department of Neurosurgery, Hospital de Pediatría Juan P. Garrahan, Ciudad Autónoma de Buenos Aires, Argentina. |
| المصدر: | Surgical neurology international [Surg Neurol Int] 2024 Apr 12; Vol. 15, pp. 130. Date of Electronic Publication: 2024 Apr 12 (Print Publication: 2024). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Scientific Scholar LLC Country of Publication: United States NLM ID: 101535836 Publication Model: eCollection Cited Medium: Print ISSN: 2229-5097 (Print) Linking ISSN: 21527806 NLM ISO Abbreviation: Surg Neurol Int Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: Pittsford, NY, USA : Scientific Scholar LLC Original Publication: Mumbai : Medknow |
| مستخلص: | Background: The management of the central nervous system (CNS) tumors in the pediatric population is crucial in neurosurgical practice. The World Health Organization (WHO) has evolved its classification of CNS tumors from the 19 th century to the 5 th edition, published in 2021, incorporating molecular advancements. This transition from morphology to molecular characterization is ongoing. Methods: This manuscript analyzes the modifications introduced in the 5 th edition of WHO's CNS tumor classification, particularly focusing on pediatric tumor families. The paper integrates clinical, morphological, and molecular information, aiming to guide pediatric neurosurgeons in their daily practice and interdisciplinary discussions. Results: The 5 th edition of the WHO classification introduces a hybrid taxonomy that incorporates both molecular and histological components. The terminology shifts from "entity" to "type" and "subtype," aiming to standardize terminology. Tumor grading experiences changes, integrating molecular biomarkers for prognosis. The concept of integrated layered diagnosis is emphasized, where molecular and histological information is combined systematically. Conclusion: The 5 th edition of the WHO CNS classification signifies a paradigm shift toward molecular characterization. The incorporation of molecular advances, the layered diagnostic approach, and the inclusion of clinical, morphological, and molecular information aim to provide comprehensive insights into pediatric CNS tumors. This classification offers valuable guidance for pediatric neurosurgeons, aiding in precise diagnosis and treatment planning for these complex neoplasms. Competing Interests: There are no conflicts of interest. (Copyright: © 2024 Surgical Neurology International.) |
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| فهرسة مساهمة: | Keywords: Brain tumors; Central nervous system; Pediatric central nervous system tumors; Pediatric neurooncology; Pediatrics; World Health Organization classification |
| تواريخ الأحداث: | Date Created: 20240514 Latest Revision: 20240515 |
| رمز التحديث: | 20240515 |
| مُعرف محوري في PubMed: | PMC11090558 |
| DOI: | 10.25259/SNI_681_2023 |
| PMID: | 38742003 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2229-5097 |
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| DOI: | 10.25259/SNI_681_2023 |