دورية أكاديمية
أعرض في EDS

Magnetic field assisted centrifugal acceleration thin-layer chromatography: An approach to investigate the magnetic field effects on separation parameters including retention factor difference, selectivity factor, and resolution.

التفاصيل البيبلوغرافية
العنوان: Magnetic field assisted centrifugal acceleration thin-layer chromatography: An approach to investigate the magnetic field effects on separation parameters including retention factor difference, selectivity factor, and resolution.
المؤلفون: Namdari R; Department of Analytical Chemistry, Faculty of Chemistry, K.N. Toosi University of Technology, P.O. Box 16315-1618, Postal Code 15418-49611, Tehran, Iran; Nanomaterial, Separation and Trace Analysis Research Lab, K.N. Toosi University of Technology, P.O. Box 16315-1618, Postal Code 15418-49611, Tehran, Iran., Seidi S; Department of Analytical Chemistry, Faculty of Chemistry, K.N. Toosi University of Technology, P.O. Box 16315-1618, Postal Code 15418-49611, Tehran, Iran; Nanomaterial, Separation and Trace Analysis Research Lab, K.N. Toosi University of Technology, P.O. Box 16315-1618, Postal Code 15418-49611, Tehran, Iran. Electronic address: s.seidi@kntu.ac.ir., Namdari MR; Department of Mechanical Engineering, Hakim Sabzevari University, P.O. Box 397, Postal Code 9618676115, Sabzevar, Iran.
المصدر: Journal of chromatography. A [J Chromatogr A] 2024 Jul 05; Vol. 1726, pp. 464972. Date of Electronic Publication: 2024 May 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier, 1993-
مواضيع طبية MeSH: Magnetic Fields* , Antifungal Agents*/analysis , Antifungal Agents*/chemistry , Antifungal Agents*/isolation & purification , Ketoconazole*/chemistry , Ketoconazole*/analysis, Chromatography, Thin Layer/methods ; Clotrimazole/chemistry ; Clotrimazole/analysis ; Centrifugation/methods ; Silicon Dioxide/chemistry
مستخلص: The effect of internal and external magnetic fields on the separation of antifungal drugs by centrifugal acceleration thin-layer chromatography was reported for the first time. External and internal magnetic fields were applied using neodymium magnets and CoFe 2 O 4 @SiO 2 ferromagnetic nanoparticles. Separation of ketoconazole and clotrimazole was performed using a mobile phase consisting of n-hexane, ethyl acetate, ethanol, and ammonia (2.0:2.0:0.5:0.2, v/v). The influence of the magnetic field on the entire chromatographic system led to changes in the properties of the stationary and mobile phases and the analytes affecting the retention factor, shape, and width of the separated rings. The extent of this impact depended on the structure of the analyte and the type and intensity of the magnetic field. In the presence of the external magnetic field, there were more significant changes in the chromatographic parameters of the drugs, especially the width of the separated rings, and ketoconazole was more affected than clotrimazole. The changes are conceivably due to the effect of the magnetic field on the analyte distribution between the stationary and mobile phases, which is also caused by the possibility of the magnetic field affecting the viscosity, surface tension, and surface free energy between the stationary and mobile phases.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Antifungal drugs; Centrifugal acceleration thin-layer chromatography; Ferromagnetic nanoparticles; Lipophilicity; Magnetic field
تواريخ الأحداث: Date Created: 20240514 Date Completed: 20240521 Latest Revision: 20240521
رمز التحديث: 20240522
DOI: 10.1016/j.chroma.2024.464972
PMID: 38744184
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3778
DOI:10.1016/j.chroma.2024.464972