دورية أكاديمية
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Key morphological features of human pyramidal neurons.

التفاصيل البيبلوغرافية
العنوان: Key morphological features of human pyramidal neurons.
المؤلفون: Benavides-Piccione R; Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, Madrid 28223, Spain.; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Avda. Doctor Arce 37, Madrid 28002, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Valderrebollo 5, Madrid 28031, Spain., Blazquez-Llorca L; Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, Madrid 28223, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Valderrebollo 5, Madrid 28031, Spain.; Departamento de Tecnología Fotónica y Bioingeniería, ETSI Telecomunicación, Universidad Politécnica de Madrid, Madrid 28040, Spain., Kastanauskaite A; Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, Madrid 28223, Spain., Fernaud-Espinosa I; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Avda. Doctor Arce 37, Madrid 28002, Spain., Tapia-González S; Laboratorio de Neurofisiología Celular, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., DeFelipe J; Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, Madrid 28223, Spain.; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Avda. Doctor Arce 37, Madrid 28002, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Valderrebollo 5, Madrid 28031, Spain.
المصدر: Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 May 02; Vol. 34 (5).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9110718 Publication Model: Print Cited Medium: Internet ISSN: 1460-2199 (Electronic) Linking ISSN: 10473211 NLM ISO Abbreviation: Cereb Cortex Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Oxford University Press, c1991-
مواضيع طبية MeSH: Pyramidal Cells*/physiology, Humans ; Animals ; Male ; Female ; Mice ; Adult ; Dendritic Spines/physiology ; Dendritic Spines/ultrastructure ; Temporal Lobe/cytology ; Dendrites/physiology ; Middle Aged ; Axons/physiology ; Species Specificity
مستخلص: The basic building block of the cerebral cortex, the pyramidal cell, has been shown to be characterized by a markedly different dendritic structure among layers, cortical areas, and species. Functionally, differences in the structure of their dendrites and axons are critical in determining how neurons integrate information. However, within the human cortex, these neurons have not been quantified in detail. In the present work, we performed intracellular injections of Lucifer Yellow and 3D reconstructed over 200 pyramidal neurons, including apical and basal dendritic and local axonal arbors and dendritic spines, from human occipital primary visual area and associative temporal cortex. We found that human pyramidal neurons from temporal cortex were larger, displayed more complex apical and basal structural organization, and had more spines compared to those in primary sensory cortex. Moreover, these human neocortical neurons displayed specific shared and distinct characteristics in comparison to previously published human hippocampal pyramidal neurons. Additionally, we identified distinct morphological features in human neurons that set them apart from mouse neurons. Lastly, we observed certain consistent organizational patterns shared across species. This study emphasizes the existing diversity within pyramidal cell structures across different cortical areas and species, suggesting substantial species-specific variations in their computational properties.
(© The Author(s) 2024. Published by Oxford University Press.)
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معلومات مُعتمدة: CB06/05/0066 Centro de Investigación en Red sobre Enfermedades Neurodegenerativas; CSIC Interdisciplinary Thematic Platform (PTI) Cajal Blue Brain; 785907 European Union's Horizon 2020 Framework Programme for Research and Innovation
فهرسة مساهمة: Keywords: 3D reconstructions; CA1; area 17; area 20; area 21; comparative neuroanatomy; cortex; dendritic structure; intracellular injections; morphology; spines; temporal; visual
تواريخ الأحداث: Date Created: 20240515 Date Completed: 20240515 Latest Revision: 20240518
رمز التحديث: 20240518
مُعرف محوري في PubMed: PMC11094408
DOI: 10.1093/cercor/bhae180
PMID: 38745556
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-2199
DOI:10.1093/cercor/bhae180