تقرير
Imatinib-induced dermatomyositis sine dermatitis - a rare case report.
| العنوان: | Imatinib-induced dermatomyositis sine dermatitis - a rare case report. |
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| المؤلفون: | Silva A; Rheumatology Department, EULAR Centre of Excellence, Unidade Local de Saúde Santa Maria, Lisbon Academic Medical Center and European Reference Network on Rare Connective Tissue and Musculoskeletal Diseases Network (ERN-ReCONNET), Lisbon, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal., Romão VC; Rheumatology Department, EULAR Centre of Excellence, Unidade Local de Saúde Santa Maria, Lisbon Academic Medical Center and European Reference Network on Rare Connective Tissue and Musculoskeletal Diseases Network (ERN-ReCONNET), Lisbon, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal., Campanilho-Marques R; Rheumatology Department, EULAR Centre of Excellence, Unidade Local de Saúde Santa Maria, Lisbon Academic Medical Center and European Reference Network on Rare Connective Tissue and Musculoskeletal Diseases Network (ERN-ReCONNET), Lisbon, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.; Unidade de Reumatologia Pediátrica, Unidade Local de Saúde Santa Maria, Lisbon, Portugal. |
| المصدر: | Frontiers in immunology [Front Immunol] 2024 Apr 29; Vol. 15, pp. 1398453. Date of Electronic Publication: 2024 Apr 29 (Print Publication: 2024). |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Dermatomyositis*/chemically induced , Dermatomyositis*/diagnosis , Dermatomyositis*/immunology , Imatinib Mesylate*/adverse effects , Imatinib Mesylate*/therapeutic use, Humans ; Female ; Aged ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Dermatitis/etiology ; Dermatitis/diagnosis ; Dermatitis/drug therapy |
| مستخلص: | Idiopathic Inflammatory Myopathies are rare conditions with several heterogeneous disease subtypes. They can range from limited muscle or skin involvement to severe, systemic, life-threatening disease. Although the etiology is unknown, some evidence suggests a role for external agents, particularly drugs. Herein, we present a case of a 71-year-old woman with chronic myeloid leukemia who developed imatinib-induced dermatomyositis sine dermatitis . The presentation was predominantly muscular, characterized by proximal muscle weakness and myalgia of the lower limbs, with positive anti-Mi2a antibodies. Spontaneous recovery was observed after drug discontinuation, without the need for immunosuppressive therapy. This is the first confirmed description of an imatinib-induced dermatomyositis sine dermatitis. It reflects the importance of a high awareness from rheumatologists and hematologists to accurately anticipate and identify similar situations. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Silva, Romão and Campanilho-Marques.) |
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| فهرسة مساهمة: | Keywords: autoantibodies; dermatomyositis sine dermatitis; imatinib mesylate; inflammatory myopathies; proximal muscle weakness |
| تواريخ الأحداث: | Date Created: 20240515 Date Completed: 20240515 Latest Revision: 20240516 |
| رمز التحديث: | 20240516 |
| مُعرف محوري في PubMed: | PMC11092370 |
| DOI: | 10.3389/fimmu.2024.1398453 |
| PMID: | 38745660 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2024.1398453 |